Human Gene CDK11B (uc001ags.1) Description and Page Index
  Description: Homo sapiens cyclin-dependent kinase 11B (CDK11B), transcript variant 2, mRNA.
RefSeq Summary (NM_033487): This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Transcript (Including UTRs)
   Position: hg19 chr1:1,571,100-1,647,917 Size: 76,818 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr1:1,571,126-1,647,813 Size: 76,688 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,571,100-1,647,917)mRNA (may differ from genome)Protein (640 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CD11B_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase 11B; EC=2.7.11.22; AltName: Full=Cell division cycle 2-like protein kinase 1; Short=CLK-1; AltName: Full=Cell division protein kinase 11B; AltName: Full=Galactosyltransferase-associated protein kinase p58/GTA; AltName: Full=PITSLRE serine/threonine-protein kinase CDC2L1; AltName: Full=p58 CLK-1;
FUNCTION: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it (By similarity).
SUBUNIT: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
INTERACTION: Q13153:PAK1; NbExp=3; IntAct=EBI-1298, EBI-1307;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
INDUCTION: The p58 isoform is specifically induced in G2/M phase of the cell cycle.
PTM: During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins.
PTM: p110C can be autophosphorylated.
MISCELLANEOUS: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C- termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.
CAUTION: Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each.
SEQUENCE CAUTION: Sequence=AAC83664.1; Type=Erroneous gene model prediction; Sequence=AAF36538.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDK11B
CDC HuGE Published Literature: CDK11B

-  MalaCards Disease Associations
  MalaCards Gene Search: CDK11B
Diseases sorted by gene-association score: neuroblastoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.02 RPKM in Testis
Total median expression: 737.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.90104-0.162 Picture PostScript Text
3' UTR -5.9026-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on P21127
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000278 mitotic cell cycle
GO:0001558 regulation of cell growth
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008283 cell proliferation
GO:0016310 phosphorylation
GO:0050684 regulation of mRNA processing

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC062579 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:5199576), partial cds.
BC033069 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:3610222), **** WARNING: chimeric clone ****.
AK000081 - Homo sapiens cDNA FLJ20074 fis, clone COL02336, highly similar to M37712 Human p58/GTA.
U04815 - Human protein kinase PITSLRE alpha 1 mRNA, complete cds.
AF067524 - Homo sapiens PITSLRE protein kinase beta SV12 isoform (CDC2L2) mRNA, complete cds.
AF067512 - Homo sapiens PITSLRE protein kinase alpha SV1 isoform (CDC2L1) mRNA, complete cds.
AF067513 - Homo sapiens PITSLRE protein kinase alpha SV4 isoform (CDC2L1) mRNA, complete cds.
AF067514 - Homo sapiens PITSLRE protein kinase alpha SV5 isoform (CDC2L1) mRNA, complete cds.
AF067515 - Homo sapiens PITSLRE protein kinase alpha SV9 isoform (CDC2L1) mRNA, complete cds.
AF067516 - Homo sapiens PITSLRE protein kinase alpha SV10 isoform (CDC2L1) mRNA, complete cds.
AF067517 - Homo sapiens PITSLRE protein kinase alpha SV11 isoform (CDC2L1) mRNA, complete cds.
U04816 - Human protein kinase PITSLRE alpha 2-2 mRNA, complete cds.
U04817 - Human protein kinase PITSLRE alpha 2-3 mRNA, complete cds.
U04818 - Human protein kinase PITSLRE alpha 2-4 mRNA, complete cds.
U04824 - Human protein kinase PITSLRE alpha 2-1 mRNA, complete cds.
BC139777 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:40121212), partial cds.
AK304679 - Homo sapiens cDNA FLJ59152 complete cds, highly similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).
BC140714 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:176391 IMAGE:9021582), complete cds.
BC171773 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:198488 IMAGE:9054427), complete cds.
AF174497 - Homo sapiens GR AF-1 coactivator 3 mRNA, partial cds.
JD412529 - Sequence 393553 from Patent EP1572962.
JD395264 - Sequence 376288 from Patent EP1572962.
JD125495 - Sequence 106519 from Patent EP1572962.
JD022652 - Sequence 3676 from Patent EP1572962.
JD029702 - Sequence 10726 from Patent EP1572962.
JD345120 - Sequence 326144 from Patent EP1572962.
JD292635 - Sequence 273659 from Patent EP1572962.
AX033421 - Sequence 2 from Patent WO0044896.
JD043805 - Sequence 24829 from Patent EP1572962.
JD468561 - Sequence 449585 from Patent EP1572962.
JD073738 - Sequence 54762 from Patent EP1572962.
JD445039 - Sequence 426063 from Patent EP1572962.
JD065460 - Sequence 46484 from Patent EP1572962.
JD043760 - Sequence 24784 from Patent EP1572962.
JD436361 - Sequence 417385 from Patent EP1572962.
JD468542 - Sequence 449566 from Patent EP1572962.
JD471391 - Sequence 452415 from Patent EP1572962.
JD468559 - Sequence 449583 from Patent EP1572962.
JD073737 - Sequence 54761 from Patent EP1572962.
JD471164 - Sequence 452188 from Patent EP1572962.
JD340003 - Sequence 321027 from Patent EP1572962.
JD178297 - Sequence 159321 from Patent EP1572962.
JD471387 - Sequence 452411 from Patent EP1572962.
JD248560 - Sequence 229584 from Patent EP1572962.
JD057707 - Sequence 38731 from Patent EP1572962.
BC009375 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4121554), partial cds.
JD094062 - Sequence 75086 from Patent EP1572962.
JD075744 - Sequence 56768 from Patent EP1572962.
BC110905 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone MGC:131975 IMAGE:6151813), complete cds.
AB209095 - Homo sapiens mRNA for cell division cycle 2-like 2 isoform 4 variant protein.
AF067525 - Homo sapiens PITSLRE protein kinase beta SV13 isoform (CDC2L2) mRNA, complete cds.
AF067518 - Homo sapiens PITSLRE protein kinase beta SV8 isoform (CDC2L2) mRNA, complete cds.
AF067519 - Homo sapiens PITSLRE protein kinase beta SV1 isoform (CDC2L2) mRNA, complete cds.
AF067520 - Homo sapiens PITSLRE protein kinase beta SV2 isoform (CDC2L2) mRNA, complete cds.
AF067521 - Homo sapiens PITSLRE protein kinase beta SV3 isoform (CDC2L2) mRNA, complete cds.
AF067522 - Homo sapiens PITSLRE protein kinase beta SV6 isoform (CDC2L2) mRNA, complete cds.
AF067523 - Homo sapiens PITSLRE protein kinase beta SV7 isoform (CDC2L2) mRNA, complete cds.
U07704 - Human protein kinase PITSLRE isoform PBETA21 (p58CDC2L1) mRNA, complete cds.
U07705 - Human protein kinase PITSLRE isoform PBETA22 (p58CDC2L1) mRNA, complete cds.
AK303451 - Homo sapiens cDNA FLJ56557 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22).
AK303446 - Homo sapiens cDNA FLJ56415 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22).
AK301495 - Homo sapiens cDNA FLJ55257 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L2 (EC 2.7.11.22).
AK295607 - Homo sapiens cDNA FLJ59025 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).
BC028187 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4397976), partial cds.
BC009375 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4121554), partial cds.
JD075744 - Sequence 56768 from Patent EP1572962.
JD460770 - Sequence 441794 from Patent EP1572962.
JD470779 - Sequence 451803 from Patent EP1572962.
JD354471 - Sequence 335495 from Patent EP1572962.
JD336811 - Sequence 317835 from Patent EP1572962.
JD518370 - Sequence 499394 from Patent EP1572962.
JD554198 - Sequence 535222 from Patent EP1572962.
JD274488 - Sequence 255512 from Patent EP1572962.
AF067527 - Homo sapiens PITSLRE protein kinase beta SV16 isoform (CDC2L2) mRNA, partial cds.
AF067529 - Homo sapiens PITSLRE protein kinase beta SV18 isoform (CDC2L2) mRNA, partial cds.
AF067526 - Homo sapiens PITSLRE protein kinase beta SV15 isoform (CDC2L2) mRNA, partial cds.
AF067528 - Homo sapiens PITSLRE protein kinase beta SV17 isoform (CDC2L2) mRNA, partial cds.
JD214789 - Sequence 195813 from Patent EP1572962.
JD214788 - Sequence 195812 from Patent EP1572962.
JD395312 - Sequence 376336 from Patent EP1572962.
JD395313 - Sequence 376337 from Patent EP1572962.
JD436764 - Sequence 417788 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF

Reactome (by CSHL, EBI, and GO)

Protein P21127 (Reactome details) participates in the following event(s):

R-HSA-380455 Recruitment of CDK11p58 to the centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380287 Centrosome maturation
R-HSA-69275 G2/M Transition
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: AF067515, CD11B_HUMAN, CDC2L1, CDK11, NM_033487, NP_277022, O95265, P21127, PITSLREA, PK58, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
UCSC ID: uc001ags.1
RefSeq Accession: NM_033487
Protein: P21127 (aka CD11B_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AF067515.1
exon count: 16CDS single in 3' UTR: no RNA size: 2525
ORF size: 1923CDS single in intron: no Alignment % ID: 99.44
txCdsPredict score: 3872.00frame shift in genome: no % Coverage: 81.31
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.