Human Gene CDK11B (uc001agy.1) Description and Page Index
  Description: Homo sapiens cyclin-dependent kinase 11B (CDK11B), transcript variant 8, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:1,571,100-1,655,775 Size: 84,676 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr1:1,571,126-1,654,257 Size: 83,132 Coding Exon Count: 19 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,571,100-1,655,775)mRNA (may differ from genome)Protein (780 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedReactome
Stanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDK11B
CDC HuGE Published Literature: CDK11B

-  MalaCards Disease Associations
  MalaCards Gene Search: CDK11B
Diseases sorted by gene-association score: neuroblastoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.02 RPKM in Testis
Total median expression: 737.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.0083-0.361 Picture PostScript Text
3' UTR -5.9026-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on P21127-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC062579 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:5199576), partial cds.
BC033069 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:3610222), **** WARNING: chimeric clone ****.
AK000081 - Homo sapiens cDNA FLJ20074 fis, clone COL02336, highly similar to M37712 Human p58/GTA.
U04815 - Human protein kinase PITSLRE alpha 1 mRNA, complete cds.
AF067524 - Homo sapiens PITSLRE protein kinase beta SV12 isoform (CDC2L2) mRNA, complete cds.
AF067512 - Homo sapiens PITSLRE protein kinase alpha SV1 isoform (CDC2L1) mRNA, complete cds.
AF067513 - Homo sapiens PITSLRE protein kinase alpha SV4 isoform (CDC2L1) mRNA, complete cds.
AF067514 - Homo sapiens PITSLRE protein kinase alpha SV5 isoform (CDC2L1) mRNA, complete cds.
AF067515 - Homo sapiens PITSLRE protein kinase alpha SV9 isoform (CDC2L1) mRNA, complete cds.
AF067516 - Homo sapiens PITSLRE protein kinase alpha SV10 isoform (CDC2L1) mRNA, complete cds.
AF067517 - Homo sapiens PITSLRE protein kinase alpha SV11 isoform (CDC2L1) mRNA, complete cds.
U04816 - Human protein kinase PITSLRE alpha 2-2 mRNA, complete cds.
U04817 - Human protein kinase PITSLRE alpha 2-3 mRNA, complete cds.
U04818 - Human protein kinase PITSLRE alpha 2-4 mRNA, complete cds.
U04824 - Human protein kinase PITSLRE alpha 2-1 mRNA, complete cds.
BC139777 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:40121212), partial cds.
AK304679 - Homo sapiens cDNA FLJ59152 complete cds, highly similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).
BC140714 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:176391 IMAGE:9021582), complete cds.
BC171773 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:198488 IMAGE:9054427), complete cds.
AF174497 - Homo sapiens GR AF-1 coactivator 3 mRNA, partial cds.
JD412529 - Sequence 393553 from Patent EP1572962.
JD395264 - Sequence 376288 from Patent EP1572962.
JD125495 - Sequence 106519 from Patent EP1572962.
JD022652 - Sequence 3676 from Patent EP1572962.
JD029702 - Sequence 10726 from Patent EP1572962.
JD345120 - Sequence 326144 from Patent EP1572962.
JD292635 - Sequence 273659 from Patent EP1572962.
AX033421 - Sequence 2 from Patent WO0044896.
JD043805 - Sequence 24829 from Patent EP1572962.
JD468561 - Sequence 449585 from Patent EP1572962.
JD073738 - Sequence 54762 from Patent EP1572962.
JD445039 - Sequence 426063 from Patent EP1572962.
JD065460 - Sequence 46484 from Patent EP1572962.
JD043760 - Sequence 24784 from Patent EP1572962.
JD436361 - Sequence 417385 from Patent EP1572962.
JD468542 - Sequence 449566 from Patent EP1572962.
JD471391 - Sequence 452415 from Patent EP1572962.
JD468559 - Sequence 449583 from Patent EP1572962.
JD073737 - Sequence 54761 from Patent EP1572962.
JD471164 - Sequence 452188 from Patent EP1572962.
JD340003 - Sequence 321027 from Patent EP1572962.
JD178297 - Sequence 159321 from Patent EP1572962.
JD471387 - Sequence 452411 from Patent EP1572962.
JD248560 - Sequence 229584 from Patent EP1572962.
JD057707 - Sequence 38731 from Patent EP1572962.
BC009375 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4121554), partial cds.
JD094062 - Sequence 75086 from Patent EP1572962.
JD075744 - Sequence 56768 from Patent EP1572962.
BC110905 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone MGC:131975 IMAGE:6151813), complete cds.
AB209095 - Homo sapiens mRNA for cell division cycle 2-like 2 isoform 4 variant protein.
AF067525 - Homo sapiens PITSLRE protein kinase beta SV13 isoform (CDC2L2) mRNA, complete cds.
AF067518 - Homo sapiens PITSLRE protein kinase beta SV8 isoform (CDC2L2) mRNA, complete cds.
AF067519 - Homo sapiens PITSLRE protein kinase beta SV1 isoform (CDC2L2) mRNA, complete cds.
AF067520 - Homo sapiens PITSLRE protein kinase beta SV2 isoform (CDC2L2) mRNA, complete cds.
AF067521 - Homo sapiens PITSLRE protein kinase beta SV3 isoform (CDC2L2) mRNA, complete cds.
AF067522 - Homo sapiens PITSLRE protein kinase beta SV6 isoform (CDC2L2) mRNA, complete cds.
AF067523 - Homo sapiens PITSLRE protein kinase beta SV7 isoform (CDC2L2) mRNA, complete cds.
U07704 - Human protein kinase PITSLRE isoform PBETA21 (p58CDC2L1) mRNA, complete cds.
U07705 - Human protein kinase PITSLRE isoform PBETA22 (p58CDC2L1) mRNA, complete cds.
AK303451 - Homo sapiens cDNA FLJ56557 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22).
AK303446 - Homo sapiens cDNA FLJ56415 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22).
AK301495 - Homo sapiens cDNA FLJ55257 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L2 (EC 2.7.11.22).
AK295607 - Homo sapiens cDNA FLJ59025 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).
BC028187 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4397976), partial cds.
BC009375 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4121554), partial cds.
JD075744 - Sequence 56768 from Patent EP1572962.
JD460770 - Sequence 441794 from Patent EP1572962.
JD470779 - Sequence 451803 from Patent EP1572962.
JD354471 - Sequence 335495 from Patent EP1572962.
JD336811 - Sequence 317835 from Patent EP1572962.
JD518370 - Sequence 499394 from Patent EP1572962.
JD554198 - Sequence 535222 from Patent EP1572962.
JD274488 - Sequence 255512 from Patent EP1572962.
AF067527 - Homo sapiens PITSLRE protein kinase beta SV16 isoform (CDC2L2) mRNA, partial cds.
AF067529 - Homo sapiens PITSLRE protein kinase beta SV18 isoform (CDC2L2) mRNA, partial cds.
AF067526 - Homo sapiens PITSLRE protein kinase beta SV15 isoform (CDC2L2) mRNA, partial cds.
AF067528 - Homo sapiens PITSLRE protein kinase beta SV17 isoform (CDC2L2) mRNA, partial cds.
JD214789 - Sequence 195813 from Patent EP1572962.
JD214788 - Sequence 195812 from Patent EP1572962.
JD395312 - Sequence 376336 from Patent EP1572962.
JD395313 - Sequence 376337 from Patent EP1572962.
JD436764 - Sequence 417788 from Patent EP1572962.
JD090259 - Sequence 71283 from Patent EP1572962.
JD565542 - Sequence 546566 from Patent EP1572962.
JD396426 - Sequence 377450 from Patent EP1572962.
JD470936 - Sequence 451960 from Patent EP1572962.
JD039352 - Sequence 20376 from Patent EP1572962.
JD437278 - Sequence 418302 from Patent EP1572962.
JD433874 - Sequence 414898 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF

Reactome (by CSHL, EBI, and GO)

Protein P21127 (Reactome details) participates in the following event(s):

R-HSA-380455 Recruitment of CDK11p58 to the centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380287 Centrosome maturation
R-HSA-69275 G2/M Transition
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: CDC2L1, CDK11, NM_033492, NP_277027, P21127-3, PITSLREA, PK58
UCSC ID: uc001agy.1
RefSeq Accession: NM_033492
Protein: P21127-3

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033492.1
exon count: 20CDS single in 3' UTR: no RNA size: 2480
ORF size: 2340CDS single in intron: no Alignment % ID: 99.63
txCdsPredict score: 4716.00frame shift in genome: no % Coverage: 97.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 1
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.