Human Gene NFIA (uc001czw.3) Description and Page Index
Description: Homo sapiens nuclear factor I/A (NFIA), transcript variant 1, mRNA. RefSeq Summary (NM_001134673): This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr1:61,547,980-61,928,460 Size: 380,481 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr1:61,548,464-61,920,992 Size: 372,529 Coding Exon Count: 11
ID:NFIA_HUMAN DESCRIPTION: RecName: Full=Nuclear factor 1 A-type; Short=NF1-A; Short=Nuclear factor 1/A; AltName: Full=CCAAT-box-binding transcription factor; Short=CTF; AltName: Full=Nuclear factor I/A; Short=NF-I/A; Short=NFI-A; AltName: Full=TGGCA-binding protein; FUNCTION: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. SUBUNIT: Binds DNA as a homodimer. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the CTF/NF-I family. SIMILARITY: Contains 1 CTF/NF-I DNA-binding domain. SEQUENCE CAUTION: Sequence=BAA92677.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00859 - CTF/NF-I family transcription modulation region PF03165 - MH1 domain PF10524 - Nuclear factor I protein pre-N-terminus
ModBase Predicted Comparative 3D Structure on Q12857
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008134 transcription factor binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006260 DNA replication GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0019079 viral genome replication GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060074 synapse maturation GO:0072189 ureter development