Human Gene GADD45A (uc001ddz.2) Description and Page Index
Description: Homo sapiens growth arrest and DNA-damage-inducible, alpha (GADD45A), transcript variant 1, mRNA. RefSeq Summary (NM_001924): This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]. Transcript (Including UTRs) Position: hg19 chr1:68,150,860-68,154,021 Size: 3,162 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr1:68,151,178-68,153,457 Size: 2,280 Coding Exon Count: 4
ID:GA45A_HUMAN DESCRIPTION: RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 alpha; AltName: Full=DNA damage-inducible transcript 1 protein; Short=DDIT-1; FUNCTION: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. SUBUNIT: Interacts with MAPK14 (By similarity). Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization. INTERACTION: Q9GZX7:AICDA; NbExp=5; IntAct=EBI-448167, EBI-3834328; Q8TAE8:GADD45GIP1; NbExp=3; IntAct=EBI-448167, EBI-372506; P80303:NUCB2; NbExp=2; IntAct=EBI-448167, EBI-2296670; Q9Y371:SH3GLB1; NbExp=2; IntAct=EBI-448167, EBI-2623095; Q13569:TDG; NbExp=3; IntAct=EBI-448167, EBI-348333; SUBCELLULAR LOCATION: Nucleus. INDUCTION: By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediated by some kinase(s) other than PKC. SIMILARITY: Belongs to the GADD45 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gadd45a/"; WEB RESOURCE: Name=Wikipedia; Note=GADD45A entry; URL="http://en.wikipedia.org/wiki/GADD45A";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GADD45A CDC HuGE Published Literature: GADD45A
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P24522
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.