Human Gene GNG12 (uc001dea.2) Description and Page Index
  Description: Homo sapiens guanine nucleotide binding protein (G protein), gamma 12 (GNG12), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:68,167,149-68,299,155 Size: 132,007 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:68,171,134-68,173,369 Size: 2,236 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:68,167,149-68,299,155)mRNA (may differ from genome)Protein (72 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Flags: Precursor;
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
SIMILARITY: Belongs to the G protein gamma family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.17 RPKM in Cells - Cultured fibroblasts
Total median expression: 1113.48 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -71.50205-0.349 Picture PostScript Text
3' UTR -1024.023985-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015898 - G-protein_gamma-like_dom
IPR001770 - Gprotein-gamma

Pfam Domains:
PF00631 - GGL domain

SCOP Domains:
48670 - Transducin (heterotrimeric G protein), gamma chain

ModBase Predicted Comparative 3D Structure on Q9UBI6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
   Protein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0042301 phosphate ion binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0021987 cerebral cortex development
GO:0032496 response to lipopolysaccharide

Cellular Component:
GO:0005834 heterotrimeric G-protein complex
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  AL832431 - Homo sapiens mRNA; cDNA DKFZp762E193 (from clone DKFZp762E193).
BC005940 - Homo sapiens guanine nucleotide binding protein (G protein), gamma 12, mRNA (cDNA clone MGC:14561 IMAGE:4049838), complete cds.
AF365871 - Homo sapiens G protein gamma 12 subunit mRNA, complete cds.
AK293101 - Homo sapiens cDNA FLJ76584 complete cds, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), gamma 12 (GNG12), mRNA.
AF119663 - Homo sapiens G-protein gamma-12 subunit mRNA, complete cds.
AF123766 - Homo sapiens G-protein gamma-12 subunit mRNA, complete cds.
AK223000 - Homo sapiens mRNA for G-protein gamma-12 subunit variant, clone: HSI06678.
LF207172 - JP 2014500723-A/14675: Polycomb-Associated Non-Coding RNAs.
MA442749 - JP 2018138019-A/14675: Polycomb-Associated Non-Coding RNAs.
AL049367 - Homo sapiens mRNA; cDNA DKFZp586B0918 (from clone DKFZp586B0918).
AK055914 - Homo sapiens cDNA FLJ31352 fis, clone MESAN2000238.
BC013090 - Homo sapiens guanine nucleotide binding protein (G protein), gamma 12, mRNA (cDNA clone IMAGE:3857807), partial cds.
AK092014 - Homo sapiens cDNA FLJ34695 fis, clone MESAN2002086.
JD330500 - Sequence 311524 from Patent EP1572962.
AF493879 - Homo sapiens guanine nucleotide binding protein gamma 12 (GNG12) mRNA, complete cds.
JF432446 - Synthetic construct Homo sapiens clone IMAGE:100073656 guanine nucleotide binding protein (G protein), gamma 12 (GNG12) gene, encodes complete protein.
KJ899221 - Synthetic construct Homo sapiens clone ccsbBroadEn_08615 GNG12 gene, encodes complete protein.
AB463703 - Synthetic construct DNA, clone: pF1KB5643, Homo sapiens GNG12 gene for guanine nucleotide binding protein (G protein) gamma 12, without stop codon, in Flexi system.
LF212038 - JP 2014500723-A/19541: Polycomb-Associated Non-Coding RNAs.
LF362695 - JP 2014500723-A/170198: Polycomb-Associated Non-Coding RNAs.
MA447615 - JP 2018138019-A/19541: Polycomb-Associated Non-Coding RNAs.
MA598272 - JP 2018138019-A/170198: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04810 - Regulation of actin cytoskeleton

Reactome (by CSHL, EBI, and GO)

Protein Q9UBI6 (Reactome details) participates in the following event(s):

R-HSA-6814418 PDCL promotes formation of G-beta:G-gamma heterodimers
R-HSA-825631 Glucagon:GCGR mediates GTP-GDP exchange
R-HSA-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit
R-HSA-392295 Gbeta:gamma recruits PI3K gamma
R-HSA-398040 Gbeta:gamma activation of PLC beta
R-HSA-750988 Inactive G alpha (z) reassociates with G beta:gamma
R-HSA-750993 Inactive G alpha (q) reassociates with G beta:gamma
R-HSA-751001 Inactive G alpha (i) reassociates with G beta:gamma
R-HSA-751013 Inactive G alpha (s) reassociates with G beta:gamma
R-HSA-751039 Inactive G alpha (12/13) reassociates with G beta:gamma
R-HSA-112271 The receptor:G-protein complex dissociates
R-HSA-392202 Dissociation of the P2Y purinoceptor 12:Gi complex
R-HSA-392874 Dissociation of the Prostacyclin receptor:Gs complex
R-HSA-397835 Dissociation of the PAR:Gq complex
R-HSA-397891 Dissociation of the PAR:G12/13 complex
R-HSA-418576 Dissociation of the P2Y purinoceptor 1:Gq complex
R-HSA-428752 Dissociation of the TP:Gq complex
R-HSA-428918 Dissociation of the TP:G13 complex
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-751019 The Ligand:GPCR:G12/13 complex dissociates
R-HSA-751024 The Ligand:GPCR:Gz complex dissociates
R-HSA-3965447 G-protein subunits dissociate from WNT:FZD complex
R-HSA-8982640 G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
R-HSA-8850560 G-protein alpha releases G-protein heterotrimer from PDCL
R-HSA-400097 G-beta:G-gamma inhibits Adenylate cyclase
R-HSA-400037 Gi,Go Heterotrimeric G-protein complex dissociates
R-HSA-422320 Heterotrimeric G(s) complex dissociates
R-HSA-396996 Thrombin-activated PAR binds G-protein Gq
R-HSA-418581 Activated P2Y purinoceptor 1 binds G-protein Gq
R-HSA-428749 Activated TP receptor binds G-proten Gq
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-167408 The high affinity receptor complex binds to G-protein
R-HSA-392852 Activated prostacyclin receptor binds G-protein Gs
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-749446 Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
R-HSA-392187 Activated P2Y purinoceptor 12 binds G-protein Gi
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-500717 Activation of GRIK3 homomer
R-HSA-428909 Activated TP receptor binds G-protein G13
R-HSA-8982637 Opsins binds G alpha-t
R-HSA-3965444 WNT:FZD complex promotes G-protein nucleotide exchange
R-HSA-3965441 FZD recruits trimeric G-proteins
R-HSA-167429 The receptor:G-protein complex binds GTP
R-HSA-167419 The receptor:G-protein complex releases GDP
R-HSA-400092 Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
R-HSA-381706 GLP-1R:GLP-1 activates G(s)
R-HSA-381612 Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1
R-HSA-432188 AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex
R-HSA-396941 Thrombin-activated PAR binds G-protein G12/13
R-HSA-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
R-HSA-114558 Gq activation by PAR
R-HSA-418579 Gq activation by P2Y purinoceptor 1
R-HSA-428750 Gq activation by TP receptor
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-392870 Gs activation by prostacyclin receptor
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-749453 Liganded Gz-activating GPCR acts as a GEF for Gz
R-HSA-392195 Gi activation by P2Y purinoceptor 12
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-392300 G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
R-HSA-398193 PLC beta-mediated PIP2 hydrolysis
R-HSA-428917 G13 activation by TP receptor
R-HSA-420883 Opsins act as GEFs for G alpha-t
R-HSA-432195 AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP
R-HSA-1013020 Activation of GIRK/Kir3 Channels
R-HSA-114552 G12/13 activation by PAR
R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-4086398 Ca2+ pathway
R-HSA-418597 G alpha (z) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-163685 Energy Metabolism
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-111885 Opioid Signalling
R-HSA-397795 G-protein beta:gamma signalling
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-392518 Signal amplification
R-HSA-418346 Platelet homeostasis
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-391251 Protein folding
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-422356 Regulation of insulin secretion
R-HSA-445717 Aquaporin-mediated transport
R-HSA-1430728 Metabolism
R-HSA-451326 Activation of kainate receptors upon glutamate binding
R-HSA-195721 Signaling by WNT
R-HSA-372790 Signaling by GPCR
R-HSA-109582 Hemostasis
R-HSA-392499 Metabolism of proteins
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-382551 Transport of small molecules
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-162582 Signal Transduction
R-HSA-500792 GPCR ligand binding
R-HSA-991365 Activation of GABAB receptors
R-HSA-1296059 G protein gated Potassium channels
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-977444 GABA B receptor activation
R-HSA-1296065 Inwardly rectifying K+ channels
R-HSA-112316 Neuronal System
R-HSA-977443 GABA receptor activation
R-HSA-1296071 Potassium Channels

-  Other Names for This Gene
  Alternate Gene Symbols: GBG12_HUMAN, NM_018841, NP_061329, Q9BRV5, Q9UBI6
UCSC ID: uc001dea.2
RefSeq Accession: NM_018841
Protein: Q9UBI6 (aka GBG12_HUMAN or GBGC_HUMAN)
CCDS: CCDS30749.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_018841.5
exon count: 4CDS single in 3' UTR: no RNA size: 4427
ORF size: 219CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 638.00frame shift in genome: no % Coverage: 99.59
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.