Human Gene PTGER3 (uc001dfn.3) Description and Page Index
  Description: Homo sapiens prostaglandin E receptor 3 (subtype EP3) (PTGER3), transcript variant 6, mRNA.
RefSeq Summary (NM_198716): The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X83861.1, BC024229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: hg19 chr1:71,349,439-71,513,491 Size: 164,053 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:71,349,632-71,513,260 Size: 163,629 Coding Exon Count: 5 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:71,349,439-71,513,491)mRNA (may differ from genome)Protein (429 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PTGER3
CDC HuGE Published Literature: PTGER3
Positive Disease Associations: asthma asthma, aspirin-intolerant , Basophils , Cholesterol , Inflammation|Premature Birth
Related Studies:
  1. asthma asthma, aspirin-intolerant
    Kim, S. H. et al. 2007, Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma, Pharmacogenet Genomics 2007 17(4) 295-304. [PubMed 17496729]
    These findings suggest that genetic polymorphisms in PTGER2, PTGER3, PTGER4, PTGIR, and TBXA2R play important roles in the pathogenesis of aspirin-intolerant asthma.
  2. Basophils
    , , . [PubMed 0]
  3. Cholesterol
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: PTGER3
Diseases sorted by gene-association score: mast cell neoplasm (8), antenatal bartter syndrome (8), chronic conjunctivitis (5), hypersensitivity syndrome, carbamazepine-induced (5), ocular hyperemia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.98 RPKM in Uterus
Total median expression: 123.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.60231-0.522 Picture PostScript Text
3' UTR -60.30193-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001481 - EP3_rcpt_2
IPR017452 - GPCR_Rhodpsn_supfam
IPR008365 - Prostanoid_rcpt
IPR001244 - Prostglndn_DP_rcpt
IPR000265 - Prostglndn_EP3_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q147X8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  HQ447638 - Synthetic construct Homo sapiens clone IMAGE:100070984; CCSB013165_02 prostaglandin E receptor 3 (subtype EP3) (PTGER3) gene, encodes complete protein.
X83857 - H.sapiens mRNA for prostaglandin E receptor (EP3a1).
X83859 - H.sapiens mRNA for prostaglandin E receptor (EP3b).
X83861 - H.sapiens mRNA for prostaglandin E receptor (EP3d).
X83863 - H.sapiens mRNA for prostaglandin E receptor (EP3f).
D86097 - Homo sapiens mRNA for prostaglandin EP3 receptor subtype isoform, complete cds.
D86098 - Homo sapiens mRNA for prostaglandin EP3 receptor subtype isoform, complete cds.
U13214 - Human protaglandin receptor EP3F mRNA, complete cds.
U13215 - Human protaglandin receptor EP3E mRNA, complete cds.
BC024229 - Homo sapiens prostaglandin E receptor 3 (subtype EP3), mRNA (cDNA clone MGC:27302 IMAGE:4660371), complete cds.
D38298 - Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 1b isoform, complete cds.
D38301 - Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 3 isoform, complete cds.
L27489 - Homo sapiens prostanoid EP3-III receptor mRNA, complete cds.
D38300 - Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 4 isoform, complete cds.
S69326 - prostaglandin E receptor EP3 subtype [human, erythroleukaemia cells, mRNA, 1488 nt].
AK290634 - Homo sapiens cDNA FLJ77072 complete cds, highly similar to Homo sapiens prostaglandin E receptor 3 (subtype EP3) (PTGER3), transcript variant 9, mRNA.
KJ905881 - Synthetic construct Homo sapiens clone ccsbBroadEn_15551 PTGER3 gene, encodes complete protein.
AY429108 - Homo sapiens prostaglandin E receptor 3 subtype isoform VI mRNA, complete cds.
AY387856 - Homo sapiens prostaglandin E receptor 3 subtype EP3 (PTGER3) mRNA, complete cds; alternatively spliced.
U13216 - Human protaglandin receptor EP3A1 mRNA, complete cds.
BC118578 - Homo sapiens prostaglandin E receptor 3 (subtype EP3), mRNA (cDNA clone MGC:141829 IMAGE:40069637), complete cds.
BC118659 - Homo sapiens prostaglandin E receptor 3 (subtype EP3), mRNA (cDNA clone MGC:141828 IMAGE:40069636), complete cds.
KJ901675 - Synthetic construct Homo sapiens clone ccsbBroadEn_11069 PTGER3 gene, encodes complete protein.
X83862 - H.sapiens mRNA for prostaglandin E receptor (EP3e).
EF534325 - Homo sapiens prostaglandin E receptor 3 subtype EP3 isoform 4 (PTGER3) mRNA, partial cds, alternatively spliced.
L32662 - Human prostaglandin E2 receptor EP3 subtype isoform IV mRNA, complete cds.
JD414691 - Sequence 395715 from Patent EP1572962.
JD397005 - Sequence 378029 from Patent EP1572962.
JD476663 - Sequence 457687 from Patent EP1572962.
JD560656 - Sequence 541680 from Patent EP1572962.
JD120441 - Sequence 101465 from Patent EP1572962.
JD546069 - Sequence 527093 from Patent EP1572962.
JD311782 - Sequence 292806 from Patent EP1572962.
JD213174 - Sequence 194198 from Patent EP1572962.
X83858 - H.sapiens mRNA for prostaglandin E receptor (EP3a2).
U13218 - Human protaglandin receptor EP3A mRNA, complete cds.
L27490 - Homo sapiens prostanoid EP3-I receptor mRNA, complete cds.
D38297 - Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 1a isoform, complete cds.
AK315825 - Homo sapiens cDNA, FLJ79474 complete cds, highly similar to Prostaglandin E2 receptor, EP3 subtype.
L26976 - Human prostaglandin receptor (PGE-2) mRNA, complete cds.
X83860 - H.sapiens mRNA for prostaglandin E receptor (EP3c).
U13217 - Human protaglandin receptor EP3D mRNA, complete cds.
L27488 - Homo sapiens prostanoid EP3-II receptor mRNA, complete cds.
S69200 - EP3 prostanoid receptor isoform EP 3-II {alternatively spliced} [human, mRNA, 1682 nt].
D38299 - Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 2 isoform, complete cds.
AB451481 - Homo sapiens PTGER3 mRNA for prostaglandin E receotor EP3 subtype 3 isoform, partial cds, clone: FLJ80357SAAF.
CU692894 - Synthetic construct Homo sapiens gateway clone IMAGE:100022290 5' read PTGER3 mRNA.
JD458363 - Sequence 439387 from Patent EP1572962.
JD407012 - Sequence 388036 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction

BioCarta from NCI Cancer Genome Anatomy Project
h_eicosanoidPathway - Eicosanoid Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: BC118578, NM_198716, NP_942009, Q147X8, Q147X8_HUMAN
UCSC ID: uc001dfn.3
RefSeq Accession: NM_198716
Protein: Q147X8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC118578.1
exon count: 5CDS single in 3' UTR: no RNA size: 1504
ORF size: 1290CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2154.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.