Human Gene SHC1 (uc001ffy.3) Description and Page Index
  Description: Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), nuclear gene encoding mitochondrial protein, transcript variant 5, mRNA.
RefSeq Summary (NM_001202859): This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: hg19 chr1:154,934,774-154,946,959 Size: 12,186 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr1:154,936,279-154,942,672 Size: 6,394 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:154,934,774-154,946,959)mRNA (may differ from genome)Protein (428 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: SHC1_HUMAN
DESCRIPTION: RecName: Full=SHC-transforming protein 1; AltName: Full=SHC-transforming protein 3; AltName: Full=SHC-transforming protein A; AltName: Full=Src homology 2 domain-containing-transforming protein C1; Short=SH2 domain protein C1;
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with TRIM31. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTT (By similarity). Interacts with ALK, GAB2, GRB7 and KIT. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with PTK2/FAK1.
INTERACTION: P05067:APP; NbExp=5; IntAct=EBI-78835, EBI-77613; P00533:EGFR; NbExp=5; IntAct=EBI-78835, EBI-297353; P03372-4:ESR1; NbExp=2; IntAct=EBI-78835, EBI-4309277; P62993:GRB2; NbExp=8; IntAct=EBI-78835, EBI-401755; P08069:IGF1R; NbExp=2; IntAct=EBI-1000553, EBI-475981;
SUBCELLULAR LOCATION: Cytoplasm.
SUBCELLULAR LOCATION: Isoform p46Shc: Mitochondrion matrix. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.
SUBCELLULAR LOCATION: Isoform p66Shc: Mitochondrion (By similarity). Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation (By similarity).
TISSUE SPECIFICITY: Widely expressed. Expressed in neural stem cells but absent in mature neurons.
DOMAIN: In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).
PTM: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue.
SIMILARITY: Contains 1 PID domain.
SIMILARITY: Contains 1 SH2 domain.
SEQUENCE CAUTION: Sequence=CAI13254.1; Type=Erroneous gene model prediction;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SHC1
CDC HuGE Published Literature: SHC1

-  MalaCards Disease Associations
  MalaCards Gene Search: SHC1
Diseases sorted by gene-association score: astrocytoma (3), insulin-like growth factor i (2), breast cancer (2), epidermolysis bullosa, junctional, with pyloric stenosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 111.75 RPKM in Cells - Cultured fibroblasts
Total median expression: 1424.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.90239-0.380 Picture PostScript Text
3' UTR -544.781505-0.362 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR006019 - PID_domain
IPR006020 - PTyr_interaction_dom
IPR000980 - SH2

Pfam Domains:
PF00017 - SH2 domain
PF00640 - Phosphotyrosine interaction domain (PTB/PID)

SCOP Domains:
50729 - PH domain-like
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1MIL
- X-ray MuPIT

1N3H
- NMR MuPIT

1OY2
- NMR MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
1QG1 - NMR MuPIT 1SHC - NMR MuPIT 1TCE - NMR MuPIT
1WCP - Model 2L1C - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P29353
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
 Protein Sequence  Protein Sequence 
 Alignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001784 phosphotyrosine binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0030971 receptor tyrosine kinase binding
GO:0046875 ephrin receptor binding
GO:0048408 epidermal growth factor binding

Biological Process:
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0035723 interleukin-15-mediated signaling pathway
GO:0036498 IRE1-mediated unfolded protein response
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0040008 regulation of growth
GO:0042127 regulation of cell proliferation
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050900 leukocyte migration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0090322 regulation of superoxide metabolic process
GO:0098609 cell-cell adhesion

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070435 Shc-EGFR complex


-  Descriptions from all associated GenBank mRNAs
  BX647136 - Homo sapiens mRNA; cDNA DKFZp686J19171 (from clone DKFZp686J19171).
U73377 - Human p66shc (SHC) mRNA, complete cds.
BC033925 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:39145 IMAGE:4896385), complete cds.
BX647149 - Homo sapiens mRNA; cDNA DKFZp686L06171 (from clone DKFZp686L06171).
HV708928 - JP 2012506450-A/26: Methods for treating eye disorders.
HW061203 - JP 2012529430-A/78: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061205 - JP 2012529430-A/80: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482158 - Sequence 141 from Patent WO2011072091.
JA482160 - Sequence 143 from Patent WO2011072091.
JB252011 - Sequence 78 from Patent EP2440214.
JB252013 - Sequence 80 from Patent EP2440214.
JE980450 - Sequence 141 from Patent EP2862929.
JE980452 - Sequence 143 from Patent EP2862929.
LP764910 - Sequence 78 from Patent EP3276004.
LP764912 - Sequence 80 from Patent EP3276004.
X68148 - H.sapiens SHC mRNA.
BC014158 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:20839 IMAGE:4541216), complete cds.
HV708929 - JP 2012506450-A/27: Methods for treating eye disorders.
HW061204 - JP 2012529430-A/79: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061206 - JP 2012529430-A/81: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482159 - Sequence 142 from Patent WO2011072091.
JA482161 - Sequence 144 from Patent WO2011072091.
JB252012 - Sequence 79 from Patent EP2440214.
JB252014 - Sequence 81 from Patent EP2440214.
JE980451 - Sequence 142 from Patent EP2862929.
JE980453 - Sequence 144 from Patent EP2862929.
LP764911 - Sequence 79 from Patent EP3276004.
LP764913 - Sequence 81 from Patent EP3276004.
AB208849 - Homo sapiens mRNA for SHC (Src homology 2 domain containing) transforming protein 1 isoform p66Shc variant protein.
AK096169 - Homo sapiens cDNA FLJ38850 fis, clone MESAN2010031, highly similar to SHC TRANSFORMING PROTEIN.
JD192123 - Sequence 173147 from Patent EP1572962.
JD210637 - Sequence 191661 from Patent EP1572962.
JD513788 - Sequence 494812 from Patent EP1572962.
JD297493 - Sequence 278517 from Patent EP1572962.
JD221485 - Sequence 202509 from Patent EP1572962.
JD403885 - Sequence 384909 from Patent EP1572962.
JD288256 - Sequence 269280 from Patent EP1572962.
JD297191 - Sequence 278215 from Patent EP1572962.
JD484678 - Sequence 465702 from Patent EP1572962.
JD398160 - Sequence 379184 from Patent EP1572962.
BC011813 - Homo sapiens cDNA clone IMAGE:3161064, containing frame-shift errors.
BC017283 - Homo sapiens cDNA clone IMAGE:4890240, containing frame-shift errors.
AK296786 - Homo sapiens cDNA FLJ56101 complete cds, highly similar to SHC-transforming protein 1.
AK315842 - Homo sapiens cDNA, FLJ79491 complete cds, highly similar to SHC-transforming protein 1.
AK130014 - Homo sapiens cDNA FLJ26504 fis, clone KDN07054, highly similar to SHC transforming protein.
JD450347 - Sequence 431371 from Patent EP1572962.
JD482826 - Sequence 463850 from Patent EP1572962.
JD168834 - Sequence 149858 from Patent EP1572962.
JD495311 - Sequence 476335 from Patent EP1572962.
JD303038 - Sequence 284062 from Patent EP1572962.
JD491298 - Sequence 472322 from Patent EP1572962.
JD195602 - Sequence 176626 from Patent EP1572962.
AK292143 - Homo sapiens cDNA FLJ75052 complete cds, highly similar to Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2, mRNA.
AK225332 - Homo sapiens mRNA for SHC transforming protein 1 variant, clone: HEP09014.
HQ448284 - Synthetic construct Homo sapiens clone IMAGE:100071687; CCSB007372_03 SHC (Src homology 2 domain containing) transforming protein 1 (SHC1) gene, encodes complete protein.
KJ892137 - Synthetic construct Homo sapiens clone ccsbBroadEn_01531 SHC1 gene, encodes complete protein.
AB451255 - Homo sapiens SHC1 mRNA for SHC-transforming protein 1, complete cds, clone: FLJ08067AAAN.
AB451379 - Homo sapiens SHC1 mRNA for SHC-transforming protein 1, partial cds, clone: FLJ08067AAAF.
AB527815 - Synthetic construct DNA, clone: pF1KB9993, Homo sapiens SHC1 gene for SHC (Src homology 2 domain containing) transforming protein 1, without stop codon, in Flexi system.
CU680810 - Synthetic construct Homo sapiens gateway clone IMAGE:100017341 5' read SHC1 mRNA.
DL492542 - Novel nucleic acids.
DL491011 - Novel nucleic acids.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04510 - Focal adhesion
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04722 - Neurotrophin signaling pathway
hsa04910 - Insulin signaling pathway
hsa05100 - Bacterial invasion of epithelial cells
hsa05214 - Glioma
hsa05220 - Chronic myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_epoPathway - EPO Signaling Pathway
h_il4Pathway - IL 4 signaling pathway
h_bcrPathway - BCR Signaling Pathway
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_igf1Pathway - IGF-1 Signaling Pathway
h_pdgfPathway - PDGF Signaling Pathway
h_vegfPathway - VEGF, Hypoxia, and Angiogenesis
h_TPOPathway - TPO Signaling Pathway
h_il2Pathway - IL 2 signaling pathway
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_integrinPathway - Integrin Signaling Pathway
h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_ghPathway - Growth Hormone Signaling Pathway
h_il6Pathway - IL 6 signaling pathway
h_tffPathway - Trefoil Factors Initiate Mucosal Healing
h_egfPathway - EGF Signaling Pathway
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_mapkPathway - MAPKinase Signaling Pathway
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_insulinPathway - Insulin Signaling Pathway
h_ngfPathway - Nerve growth factor pathway (NGF)
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
h_tcrPathway - T Cell Receptor Signaling Pathway
h_trkaPathway - Trka Receptor Signaling Pathway
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_il3Pathway - IL 3 signaling pathway
h_longevityPathway - The IGF-1 Receptor and Longevity
h_spryPathway - Sprouty regulation of tyrosine kinase signals

Reactome (by CSHL, EBI, and GO)

Protein P29353 (Reactome details) participates in the following event(s):

R-HSA-74740 Binding of SHC1 to insulin receptor
R-HSA-177925 SHC1 binds to the phosphorylated EGF receptor:ligand complex
R-HSA-204861 Interaction of Tie2 and Shc1
R-HSA-432096 Activated integrin alphaIIb beta3 binds SHC1
R-HSA-452091 Phosphorylation of IL2RB Y338 enables SHC recruitment
R-HSA-879934 Recruitment of SHC1 is mediated by Y593 of the common beta chain
R-HSA-1225947 Binding of SHC1 to p-6Y-EGFR mutants
R-HSA-1250357 SHC1 binds P-ERBB4 isoform dimers
R-HSA-1963578 SHC1 binds phosphorylated ERBB2 heterodimers
R-HSA-5637766 Binding of SHC1 to p-5Y-EGFRvIII
R-HSA-8853737 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1
R-HSA-74746 GRB2-1:SOS1 binds p-Y427-SHC1
R-HSA-74743 Dissociation of p-Y427-SHC1 from insulin receptor
R-HSA-5686074 GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates
R-HSA-74742 Phosphorylation of SHC1
R-HSA-177933 SHC1 phosphorylation by phosphorylated EGFR
R-HSA-452100 SHC1 bound to IL2 receptor is phosphorylated
R-HSA-1225952 Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
R-HSA-1250195 SHC1 phosphorylation by ERBB2 heterodimers
R-HSA-1250348 Phosphorylation of SHC1 by ERBB4 homodimers
R-HSA-5637796 Phosphorylation of SHC1 by p-5Y-EGFRvIII
R-HSA-167056 SHC binds to the activated TrkA receptor
R-HSA-109822 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
R-HSA-8983394 IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
R-HSA-5685366 GRB2-1:SOS1 binds p-Y-SHC
R-HSA-167217 Phospho-Shc dissociates from the TrkA receptor
R-HSA-177936 GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
R-HSA-1225961 Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
R-HSA-1250486 Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
R-HSA-1250380 Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
R-HSA-5637798 Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex
R-HSA-8853734 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
R-HSA-879925 SHC1 bound to the common beta chain becomes tyrosine phosphorylated
R-HSA-167019 SHC, complexed with TrkA, is tyrosine-phosphorylated
R-HSA-109807 GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1
R-HSA-913374 Phosphorylated SHC1 recruits SHIP
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases
R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2
R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
R-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
R-HSA-1250463 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
R-HSA-1250383 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
R-HSA-8855508 p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-210993 Tie2 Signaling
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-8853659 RET signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-74749 Signal attenuation
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-167044 Signalling to RAS
R-HSA-74752 Signaling by Insulin receptor
R-HSA-177929 Signaling by EGFR
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006921 Integrin signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-1236394 Signaling by ERBB4
R-HSA-1227986 Signaling by ERBB2
R-HSA-5637812 Signaling by EGFRvIII in Cancer
R-HSA-422475 Axon guidance
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-187687 Signalling to ERKs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-109582 Hemostasis
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-162582 Signal Transduction
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-1266738 Developmental Biology
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction
R-HSA-392499 Metabolism of proteins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-1643685 Disease
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-2730886 Phosphorylation of SHC by SYK kinase
R-HSA-8851888 MET binds SHC1-2
R-HSA-2730844 Interaction of GRB2:SOS complex with p-SHC1
R-HSA-8851890 MET phosphorylates SHC1-2
R-HSA-5654404 Activated FGFR2 binds SHC1
R-HSA-5654425 Activated FGFR4 binds SHC1
R-HSA-5654573 Activated FGFR1 binds SHC1
R-HSA-5654625 Activated FGFR3 binds SHC1
R-HSA-9026493 p-Y516 of p-5Y-NTRK2 recruits SHC1
R-HSA-2396599 Recruitment of GRB2:SOS to p-5Y-LAT
R-HSA-2730837 Recruitment of GRB2:SOS to p-10Y-NTAL
R-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1
R-HSA-5686072 p-3Y-SHC1 dissociates from IGF1R
R-HSA-8934446 Activated PKC phosphorylates SHC1
R-HSA-2404195 IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1
R-HSA-8851900 SHC1-2 bound to MET recruits GRB2:SOS1
R-HSA-8934465 SHC1 binds PTPN12
R-HSA-5654582 Activated FGFR1 phosphorylates SHC1
R-HSA-5654407 Activated FGFR2 phosphorylates SHC1
R-HSA-5654634 Activated FGFR3 phosphorylates SHC1
R-HSA-5654428 Activated FGFR4 phosphorylates SHC1
R-HSA-9026890 NTRK2 phosphorylates SHC1
R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1
R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1
R-HSA-2396561 Recruitment of GADS:SLP-76 to p-5Y-LAT
R-HSA-2730848 Recruitment of GAB2 to PM and FCERI by binding to GRB2
R-HSA-2404193 IGF1R phosphorylates SHC1
R-HSA-9028328 SHC1 bound to activated NTRK2 recruits GRB2:SOS1
R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
R-HSA-2424485 Release of p-PLCG1
R-HSA-2424481 Recruitment of VAV and BTK to p-SLP-76
R-HSA-2730892 Recruitment of VAV to p-SLP-76
R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK
R-HSA-2730851 Phosphorylation of SLP-76 by p-SYK
R-HSA-2396606 Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
R-HSA-2424477 SOS mediated nucleotide exchange of RAS (SHC)
R-HSA-2730842 PI3K associates with phosphorylated GAB2
R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYN
R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
R-HSA-8851899 RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK
R-HSA-2424484 Phosphorylation of BTK by p-SYK
R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK
R-HSA-2730888 Phosphorylation of PLC-gamma
R-HSA-2730858 Autophosphorylation of BTK/ITK
R-HSA-2730840 Activation of RAC1 by VAV
R-HSA-2730841 Phosphorylation and activation of VAV
R-HSA-2730885 Recruitment of TEC kinases to p-SLP-76
R-HSA-2730833 Phosphorylation of TEC kinases by p-SYK
R-HSA-2730889 Recruitment of PAK to the membrane by binding active RAC1
R-HSA-2730856 Autophosphorylation of PAK
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-9026891 NTRK2 activates RAS signaling through SHC1
R-HSA-2424476 Activation of RAC1 by VAV2/3
R-HSA-2730847 Hydrolysis of PIP2 by PLCG
R-HSA-2730870 Phosphorylation of PIP2 to PIP3 by PI3K
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-8851805 MET activates RAS signaling
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-6806834 Signaling by MET
R-HSA-2424491 DAP12 signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-168249 Innate Immune System
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-2172127 DAP12 interactions
R-HSA-2428924 IGF1R signaling cascade
R-HSA-1227986 Signaling by ERBB2
R-HSA-1280218 Adaptive Immune System
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654743 Signaling by FGFR4
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654741 Signaling by FGFR3
R-HSA-166520 Signaling by NTRKs
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-190236 Signaling by FGFR
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5654404 Activated FGFR2 binds SHC1
R-HSA-5654425 Activated FGFR4 binds SHC1
R-HSA-5654573 Activated FGFR1 binds SHC1
R-HSA-5654625 Activated FGFR3 binds SHC1
R-HSA-9026493 p-Y516 of p-5Y-NTRK2 recruits SHC1
R-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1
R-HSA-5686072 p-3Y-SHC1 dissociates from IGF1R
R-HSA-2404195 IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1
R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1
R-HSA-5654582 Activated FGFR1 phosphorylates SHC1
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5654407 Activated FGFR2 phosphorylates SHC1
R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1
R-HSA-5654634 Activated FGFR3 phosphorylates SHC1
R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1
R-HSA-5654428 Activated FGFR4 phosphorylates SHC1
R-HSA-9026890 NTRK2 phosphorylates SHC1
R-HSA-2404193 IGF1R phosphorylates SHC1
R-HSA-9028328 SHC1 bound to activated NTRK2 recruits GRB2:SOS1
R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-9026891 NTRK2 activates RAS signaling through SHC1
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-2428924 IGF1R signaling cascade
R-HSA-1280218 Adaptive Immune System
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654743 Signaling by FGFR4
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654741 Signaling by FGFR3
R-HSA-166520 Signaling by NTRKs
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-168256 Immune System
R-HSA-190236 Signaling by FGFR
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-162582 Signal Transduction
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1
R-HSA-5686072 p-3Y-SHC1 dissociates from IGF1R
R-HSA-8934446 Activated PKC phosphorylates SHC1
R-HSA-2404195 IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1
R-HSA-8934465 SHC1 binds PTPN12
R-HSA-2404193 IGF1R phosphorylates SHC1
R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-2428924 IGF1R signaling cascade
R-HSA-1227986 Signaling by ERBB2
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B5BU19, D3DV78, NM_001202859, NP_001189788, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1, SHC, SHC1_HUMAN, SHCA
UCSC ID: uc001ffy.3
RefSeq Accession: NM_001202859
Protein: P29353 (aka SHC1_HUMAN)
CCDS: CCDS1076.1, CCDS44234.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001202859.1
exon count: 13CDS single in 3' UTR: no RNA size: 3192
ORF size: 1422CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3037.00frame shift in genome: no % Coverage: 99.19
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.