Human Gene RPS6KC1 (uc001hkd.3) Description and Page Index
  Description: Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1 (RPS6KC1), transcript variant 2, mRNA.
RefSeq Summary (NM_001136138): Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017].
Transcript (Including UTRs)
   Position: hg19 chr1:213,224,588-213,446,808 Size: 222,221 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr1:213,224,747-213,445,977 Size: 221,231 Coding Exon Count: 14 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:213,224,588-213,446,808)mRNA (may differ from genome)Protein (1054 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.16 RPKM in Testis
Total median expression: 237.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -88.30159-0.555 Picture PostScript Text
3' UTR -187.34831-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR007330 - MIT
IPR001683 - Phox
IPR000719 - Prot_kinase_cat_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF00787 - PX domain
PF04212 - MIT (microtubule interacting and transport) domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)
64268 - PX domain

ModBase Predicted Comparative 3D Structure on B1APS8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AK122989 - Homo sapiens cDNA FLJ16747 fis, clone FCBBF3008159, highly similar to Ribosomal protein S6 kinase delta-1 (EC
AK299298 - Homo sapiens cDNA FLJ50840 complete cds, highly similar to Ribosomal protein S6 kinase delta-1 (EC
AF477978 - Homo sapiens RSK-like protein (RPK118) mRNA, complete cds.
AK295053 - Homo sapiens cDNA FLJ61257 complete cds, highly similar to Ribosomal protein S6 kinase delta-1 (EC
AK122921 - Homo sapiens cDNA FLJ16601 fis, clone TESTI4007369, highly similar to Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1 (RPS6KC1).
BC104769 - Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1, mRNA (cDNA clone MGC:132429 IMAGE:8143772), complete cds.
BC143449 - Homo sapiens cDNA clone IMAGE:9051957, with apparent retained intron.
BC143473 - Homo sapiens cDNA clone IMAGE:9051981.
BC143474 - Homo sapiens cDNA clone IMAGE:9051982, containing frame-shift errors.
AB070706 - Homo sapiens RPK118 mRNA for RSK-like protein, complete cds.
BX647303 - Homo sapiens mRNA; cDNA DKFZp779O1851 (from clone DKFZp779O1851).
JD144258 - Sequence 125282 from Patent EP1572962.
JD542135 - Sequence 523159 from Patent EP1572962.
JD211256 - Sequence 192280 from Patent EP1572962.
EF491805 - Homo sapiens clone RPS6KC1 mRNA, partial sequence; alternatively spliced.
AK130279 - Homo sapiens cDNA FLJ26769 fis, clone PRS03114.
AF037447 - Homo sapiens ribosomal S6 protein kinase mRNA, complete cds.
AL356893 - Homo sapiens mRNA; cDNA DKFZp761A202 (from clone DKFZp761A202).
BC036779 - Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1, mRNA (cDNA clone IMAGE:5762997), with apparent retained intron.
JD376626 - Sequence 357650 from Patent EP1572962.
JD098906 - Sequence 79930 from Patent EP1572962.
JD286280 - Sequence 267304 from Patent EP1572962.
JD077440 - Sequence 58464 from Patent EP1572962.
JD509763 - Sequence 490787 from Patent EP1572962.
JD095676 - Sequence 76700 from Patent EP1572962.
JD521397 - Sequence 502421 from Patent EP1572962.
JD224894 - Sequence 205918 from Patent EP1572962.
JD263019 - Sequence 244043 from Patent EP1572962.
JD040020 - Sequence 21044 from Patent EP1572962.
JD370851 - Sequence 351875 from Patent EP1572962.
JD087271 - Sequence 68295 from Patent EP1572962.
JD147419 - Sequence 128443 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B1APS8, B1APS8_HUMAN, NM_001136138, NP_001129610, RP11-434B7.1-002
UCSC ID: uc001hkd.3
RefSeq Accession: NM_001136138
Protein: B1APS8 CCDS: CCDS1513.1, CCDS44317.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001136138.1
exon count: 14CDS single in 3' UTR: no RNA size: 4170
ORF size: 3165CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4935.50frame shift in genome: no % Coverage: 99.64
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.