Human Gene CNST (uc001ibp.3) Description and Page Index
Description: Homo sapiens consortin, connexin sorting protein (CNST), transcript variant 1, mRNA. RefSeq Summary (NM_152609): Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]. Transcript (Including UTRs) Position: hg19 chr1:246,729,639-246,831,884 Size: 102,246 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr1:246,754,865-246,829,207 Size: 74,343 Coding Exon Count: 10
ID:CNST_HUMAN DESCRIPTION: RecName: Full=Consortin; FUNCTION: Required for targeting of connexins to the plasma membrane. SUBUNIT: Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1 (By similarity). INTERACTION: P62136:PPP1CA; NbExp=3; IntAct=EBI-750390, EBI-357253; SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway. SIMILARITY: Belongs to the CNST family. SEQUENCE CAUTION: Sequence=BAB84968.1; Type=Frameshift; Positions=237; Sequence=BAC03735.1; Type=Frameshift; Positions=412; Sequence=CAD38922.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6PJW8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.