Human Gene ZNF692 (uc001ifb.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 692 (ZNF692), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:249,144,203-249,152,912 Size: 8,710 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr1:249,144,409-249,150,533 Size: 6,125 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:249,144,203-249,152,912)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMGIneXtProtPubMedReactome
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN692_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 692;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.28 RPKM in Brain - Cerebellum
Total median expression: 891.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -690.001552-0.445 Picture PostScript Text
3' UTR -70.90206-0.344 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2D9H
- NMR MuPIT

2DLK
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9BU19
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  BC002948 - Homo sapiens zinc finger protein 692, mRNA (cDNA clone MGC:1027 IMAGE:3533691), complete cds.
AK001070 - Homo sapiens cDNA FLJ10208 fis, clone HEMBA1006248, weakly similar to ZINC FINGER PROTEIN MFG-1.
AL133100 - Homo sapiens mRNA; cDNA DKFZp434G1221 (from clone DKFZp434G1221).
AK000538 - Homo sapiens cDNA FLJ20531 fis, clone KAT10870.
AK225535 - Homo sapiens mRNA for hypothetical protein LOC55657 variant, clone: KAT10870.
AK126079 - Homo sapiens cDNA FLJ44091 fis, clone TESTI4041954.
AF256175 - Homo sapiens unknown precursor RNA.
AB209706 - Homo sapiens mRNA for hypothetical protein FLJ20531 variant protein.
JD552448 - Sequence 533472 from Patent EP1572962.
JD096122 - Sequence 77146 from Patent EP1572962.
JD482790 - Sequence 463814 from Patent EP1572962.
JD078082 - Sequence 59106 from Patent EP1572962.
JD180962 - Sequence 161986 from Patent EP1572962.
JD066566 - Sequence 47590 from Patent EP1572962.
AK302187 - Homo sapiens cDNA FLJ61184 complete cds, highly similar to Zinc finger protein 692.
JD044397 - Sequence 25421 from Patent EP1572962.
JD326230 - Sequence 307254 from Patent EP1572962.
JD414225 - Sequence 395249 from Patent EP1572962.
KJ894229 - Synthetic construct Homo sapiens clone ccsbBroadEn_03623 ZNF692 gene, encodes complete protein.
AK298899 - Homo sapiens cDNA FLJ52729 complete cds, highly similar to Zinc finger protein 692.
AK309421 - Homo sapiens cDNA, FLJ99462.
JD025764 - Sequence 6788 from Patent EP1572962.
JD034369 - Sequence 15393 from Patent EP1572962.
JD025304 - Sequence 6328 from Patent EP1572962.
JD030214 - Sequence 11238 from Patent EP1572962.
JD133252 - Sequence 114276 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BU19 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: AL133100, B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97, ZN692_HUMAN
UCSC ID: uc001ifb.2
RefSeq Accession: NM_001136036
Protein: Q9BU19 (aka ZN692_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AL133100.1
exon count: 10CDS single in 3' UTR: no RNA size: 2742
ORF size: 948CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1070.50frame shift in genome: no % Coverage: 98.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 392# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.