Human Gene ASB13 (uc001iig.2) Description and Page Index
  Description: Homo sapiens ankyrin repeat and SOCS box containing 13 (ASB13), transcript variant 1, mRNA.
RefSeq Summary (NM_024701): The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010].
Transcript (Including UTRs)
   Position: hg19 chr10:5,680,820-5,708,558 Size: 27,739 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr10:5,682,666-5,708,514 Size: 25,849 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:5,680,820-5,708,558)mRNA (may differ from genome)Protein (278 aa)
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UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ASB13_HUMAN
DESCRIPTION: RecName: Full=Ankyrin repeat and SOCS box protein 13; Short=ASB-13;
FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
PATHWAY: Protein modification; protein ubiquitination.
INTERACTION: P27448:MARK3; NbExp=2; IntAct=EBI-707573, EBI-707595;
DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin- protein ligase complexes (By similarity).
SIMILARITY: Contains 6 ANK repeats.
SIMILARITY: Contains 1 SOCS box domain.
SEQUENCE CAUTION: Sequence=AAL57350.1; Type=Frameshift; Positions=14;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ASB13
CDC HuGE Published Literature: ASB13

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.47 RPKM in Liver
Total median expression: 430.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.0044-0.455 Picture PostScript Text
3' UTR -714.051846-0.387 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR001496 - SOCS_C

Pfam Domains:
PF00023 - Ankyrin repeat
PF07525 - SOCS box
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on Q8WXK3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0043687 post-translational protein modification

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC012056 - Homo sapiens ankyrin repeat and SOCS box-containing 13, mRNA (cDNA clone MGC:19879 IMAGE:4552643), complete cds.
AF403031 - Homo sapiens ankyrin repeat domain-containing SOCS box protein Asb-13 mRNA, partial cds.
AK023196 - Homo sapiens cDNA FLJ13134 fis, clone NT2RP3003061, weakly similar to ANKYRIN.
AK091935 - Homo sapiens cDNA FLJ34616 fis, clone KIDNE2014320.
AX747265 - Sequence 790 from Patent EP1308459.
JD309575 - Sequence 290599 from Patent EP1572962.
JD525691 - Sequence 506715 from Patent EP1572962.
JD076244 - Sequence 57268 from Patent EP1572962.
JD495937 - Sequence 476961 from Patent EP1572962.
JD434000 - Sequence 415024 from Patent EP1572962.
JD202615 - Sequence 183639 from Patent EP1572962.
JD109327 - Sequence 90351 from Patent EP1572962.
JD208877 - Sequence 189901 from Patent EP1572962.
JD275786 - Sequence 256810 from Patent EP1572962.
JD159058 - Sequence 140082 from Patent EP1572962.
JD105722 - Sequence 86746 from Patent EP1572962.
JD116828 - Sequence 97852 from Patent EP1572962.
JD522054 - Sequence 503078 from Patent EP1572962.
JD556217 - Sequence 537241 from Patent EP1572962.
JD071036 - Sequence 52060 from Patent EP1572962.
JD319492 - Sequence 300516 from Patent EP1572962.
JD446407 - Sequence 427431 from Patent EP1572962.
JD291772 - Sequence 272796 from Patent EP1572962.
JD421944 - Sequence 402968 from Patent EP1572962.
JD446406 - Sequence 427430 from Patent EP1572962.
JD054744 - Sequence 35768 from Patent EP1572962.
JD287658 - Sequence 268682 from Patent EP1572962.
JD383261 - Sequence 364285 from Patent EP1572962.
JD524107 - Sequence 505131 from Patent EP1572962.
JD020830 - Sequence 1854 from Patent EP1572962.
JD295642 - Sequence 276666 from Patent EP1572962.
JD276892 - Sequence 257916 from Patent EP1572962.
JD034389 - Sequence 15413 from Patent EP1572962.
JD081098 - Sequence 62122 from Patent EP1572962.
AK292071 - Homo sapiens cDNA FLJ78731 complete cds.
JD566193 - Sequence 547217 from Patent EP1572962.
JD494743 - Sequence 475767 from Patent EP1572962.
JD070944 - Sequence 51968 from Patent EP1572962.
JD361939 - Sequence 342963 from Patent EP1572962.
JD233156 - Sequence 214180 from Patent EP1572962.
JD100662 - Sequence 81686 from Patent EP1572962.
JD122173 - Sequence 103197 from Patent EP1572962.
JD123994 - Sequence 105018 from Patent EP1572962.
JD534316 - Sequence 515340 from Patent EP1572962.
JD210222 - Sequence 191246 from Patent EP1572962.
JD178452 - Sequence 159476 from Patent EP1572962.
JD065634 - Sequence 46658 from Patent EP1572962.
JD372659 - Sequence 353683 from Patent EP1572962.
JD085682 - Sequence 66706 from Patent EP1572962.
JD488753 - Sequence 469777 from Patent EP1572962.
JD314533 - Sequence 295557 from Patent EP1572962.
JD191086 - Sequence 172110 from Patent EP1572962.
CR457302 - Homo sapiens full open reading frame cDNA clone RZPDo834C1113D for gene ASB13, ankyrin repeat and SOCS box-containing 13; complete cds, incl. stopcodon.
KJ900857 - Synthetic construct Homo sapiens clone ccsbBroadEn_10251 ASB13 gene, encodes complete protein.
JD023352 - Sequence 4376 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WXK3 (Reactome details) participates in the following event(s):

R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-8951664 Neddylation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-597592 Post-translational protein modification
R-HSA-1280218 Adaptive Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7Q6, ASB13_HUMAN, D3DRR2, NM_024701, NP_078977, Q8WXK3, Q96EP7, Q9H8Z1
UCSC ID: uc001iig.2
RefSeq Accession: NM_024701
Protein: Q8WXK3 (aka ASB13_HUMAN or AS13_HUMAN)
CCDS: CCDS7070.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_024701.3
exon count: 6CDS single in 3' UTR: no RNA size: 2736
ORF size: 837CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1874.00frame shift in genome: no % Coverage: 99.67
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.