Human Gene ASB13 (uc001iig.2) Description and Page Index
Description: Homo sapiens ankyrin repeat and SOCS box containing 13 (ASB13), transcript variant 1, mRNA. RefSeq Summary (NM_024701): The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr10:5,680,820-5,708,558 Size: 27,739 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr10:5,682,666-5,708,514 Size: 25,849 Coding Exon Count: 6
ID:ASB13_HUMAN DESCRIPTION: RecName: Full=Ankyrin repeat and SOCS box protein 13; Short=ASB-13; FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). PATHWAY: Protein modification; protein ubiquitination. INTERACTION: P27448:MARK3; NbExp=2; IntAct=EBI-707573, EBI-707595; DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin- protein ligase complexes (By similarity). SIMILARITY: Contains 6 ANK repeats. SIMILARITY: Contains 1 SOCS box domain. SEQUENCE CAUTION: Sequence=AAL57350.1; Type=Frameshift; Positions=14;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ASB13 CDC HuGE Published Literature: ASB13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXK3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary