Human Gene MICAL2 (uc001mka.3) Description and Page Index
Description: Homo sapiens microtubule associated monooxygenase, calponin and LIM domain containing 2 (MICAL2), mRNA. RefSeq Summary (NM_014632): The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr11:12,132,138-12,285,331 Size: 153,194 Total Exon Count: 28 Strand: + Coding Region Position: hg19 chr11:12,183,703-12,284,067 Size: 100,365 Coding Exon Count: 25
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94851
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003779 actin binding GO:0004497 monooxygenase activity GO:0016491 oxidoreductase activity GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0043914 NADPH:sulfur oxidoreductase activity GO:0046872 metal ion binding GO:0071949 FAD binding