Human Gene MICAL2 (uc001mkb.3) Description and Page Index
  Description: Homo sapiens microtubule associated monooxygenase, calponin and LIM domain containing 2 (MICAL2), mRNA.
RefSeq Summary (NM_014632): The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016].
Transcript (Including UTRs)
   Position: hg19 chr11:12,183,626-12,285,331 Size: 101,706 Total Exon Count: 19 Strand: +
Coding Region
   Position: hg19 chr11:12,183,703-12,281,719 Size: 98,017 Coding Exon Count: 19 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:12,183,626-12,285,331)mRNA (may differ from genome)Protein (976 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MICAL2
CDC HuGE Published Literature: MICAL2
Positive Disease Associations: Asthma , Erythrocytes , Myocardial Infarction , Stroke , Waist Circumference
Related Studies:
  1. Asthma
    , , . [PubMed 0]
  2. Erythrocytes
    , , . [PubMed 0]
  3. Myocardial Infarction
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D001564 Benzo(a)pyrene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C014211 2,3,7,8-tetrachlorodibenzofuran
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • C547126 AZM551248
  • D000393 Air Pollutants
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 107.67 RPKM in Brain - Cerebellum
Total median expression: 541.49 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.7077-0.230 Picture PostScript Text
3' UTR -1245.953612-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00307 - Calponin homology (CH) domain
PF00412 - LIM domain
PF00890 - FAD binding domain
PF01494 - FAD binding domain
PF11971 - CAMSAP CH domain

SCOP Domains:
47576 - Calponin-homology domain, CH-domain
51735 - NAD(P)-binding Rossmann-fold domains
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain
51984 - MurCD N-terminal domain
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on O94851-4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AK302893 - Homo sapiens cDNA FLJ58714 complete cds, highly similar to Protein MICAL-2.
AK302580 - Homo sapiens cDNA FLJ58307 complete cds, moderately similar to Protein MICAL-2.
BC044577 - Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 2, mRNA (cDNA clone MGC:57164 IMAGE:5275364), complete cds.
BC015755 - Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 2, mRNA (cDNA clone IMAGE:4899149), with apparent retained intron.
AB018293 - Homo sapiens KIAA0750 mRNA for KIAA0750 protein.
AK294845 - Homo sapiens cDNA FLJ61246 complete cds, highly similar to Protein MICAL-2.
AB385380 - Synthetic construct DNA, clone: pF1KA0750, Homo sapiens MICAL2 gene for microtubule-associated monoxygenase, calponin and LIM domain-containing protein 2, complete cds, without stop codon, in Flexi system.
CU692204 - Synthetic construct Homo sapiens gateway clone IMAGE:100023183 5' read MICAL2 mRNA.
KJ898062 - Synthetic construct Homo sapiens clone ccsbBroadEn_07456 MICAL2 gene, encodes complete protein.
AB110785 - Homo sapiens MICAL2PV1 mRNA for flavoprotein oxidoreductase, complete cds.
AB110786 - Homo sapiens MICAL2PV2 mRNA for flavoprotein oxidoreductase, complete cds.
JD271242 - Sequence 252266 from Patent EP1572962.
BX538021 - Homo sapiens mRNA; cDNA DKFZp686H2469 (from clone DKFZp686H2469); complete cds.
AK123090 - Homo sapiens cDNA FLJ41095 fis, clone BLADE1000176.
BX641163 - Homo sapiens mRNA; cDNA DKFZp686H03148 (from clone DKFZp686H03148).
AF052170 - Homo sapiens clone 24589 mRNA sequence.
AK122821 - Homo sapiens cDNA FLJ16424 fis, clone BRACE3005127.
AK127301 - Homo sapiens cDNA FLJ45368 fis, clone BRHIP3017256.
AK125785 - Homo sapiens cDNA FLJ43797 fis, clone TESTI4000215.
AK090550 - Homo sapiens cDNA FLJ33231 fis, clone ASTRO2001806.
AK125552 - Homo sapiens cDNA FLJ43564 fis, clone PUAEN2006723.
AK026116 - Homo sapiens cDNA: FLJ22463 fis, clone HRC10126.
AK025186 - Homo sapiens cDNA: FLJ21533 fis, clone COL06072.
BC017104 - Homo sapiens cDNA clone IMAGE:3505978.
BC048206 - Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 2, mRNA (cDNA clone IMAGE:4842596).
BC063589 - Homo sapiens cDNA clone IMAGE:4442192, partial cds.
JD097931 - Sequence 78955 from Patent EP1572962.
JD081318 - Sequence 62342 from Patent EP1572962.
JD271027 - Sequence 252051 from Patent EP1572962.
JD085329 - Sequence 66353 from Patent EP1572962.
JD269362 - Sequence 250386 from Patent EP1572962.
JD245461 - Sequence 226485 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AB110785, KIAA0750, MICAL2PV1, MICAL2PV2, O94851-4
UCSC ID: uc001mkb.3
RefSeq Accession: NM_014632
Protein: O94851-4, splice isoform of O94851 CCDS: CCDS60728.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AB110785.1
exon count: 19CDS single in 3' UTR: no RNA size: 2931
ORF size: 2931CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 6035.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 3887# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.