Human Gene ZDHHC5 (uc001nky.1) Description and Page Index
  Description: Homo sapiens zinc finger, DHHC-type containing 5 (ZDHHC5), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:57,435,474-57,468,659 Size: 33,186 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr11:57,449,949-57,467,503 Size: 17,555 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:57,435,474-57,468,659)mRNA (may differ from genome)Protein (662 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC5; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 5; Short=DHHC-5; AltName: Full=Zinc finger protein 375;
FUNCTION: Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
SIMILARITY: Contains 1 DHHC-type zinc finger.
SEQUENCE CAUTION: Sequence=BAB21839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD18778.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.73 RPKM in Esophagus - Mucosa
Total median expression: 809.42 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -121.70241-0.505 Picture PostScript Text
3' UTR -396.111156-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q9C0B5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0018345 protein palmitoylation

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite

-  Descriptions from all associated GenBank mRNAs
  AY894889 - Homo sapiens membrane-associated DHHC5 zinc finger protein mRNA, complete cds.
AB051535 - Homo sapiens KIAA1748 mRNA for KIAA1748 protein.
JD173449 - Sequence 154473 from Patent EP1572962.
JD215964 - Sequence 196988 from Patent EP1572962.
BC026967 - Homo sapiens zinc finger, DHHC-type containing 5, mRNA (cDNA clone MGC:34718 IMAGE:3913317), complete cds.
AK023130 - Homo sapiens cDNA FLJ13068 fis, clone NT2RP3001739, weakly similar to HYPOTHETICAL 72.5 KD PROTEIN C2F7.10 IN CHROMOSOME I.
AB384284 - Synthetic construct DNA, clone: pF1KSDA1748, Homo sapiens ZDHHC5 gene for palmitoyltransferase ZDHHC5, complete cds, without stop codon, in Flexi system.
BX647707 - Homo sapiens mRNA; cDNA DKFZp686A1286 (from clone DKFZp686A1286).
CU693244 - Synthetic construct Homo sapiens gateway clone IMAGE:100019987 5' read ZDHHC5 mRNA.
DQ892450 - Synthetic construct clone IMAGE:100005080; FLH186441.01X; RZPDo839E0771D zinc finger, DHHC-type containing 5 (ZDHHC5) gene, encodes complete protein.
DQ895662 - Synthetic construct Homo sapiens clone IMAGE:100010122; FLH186437.01L; RZPDo839E0761D zinc finger, DHHC-type containing 5 (ZDHHC5) gene, encodes complete protein.
KJ902390 - Synthetic construct Homo sapiens clone ccsbBroadEn_11784 ZDHHC5 gene, encodes complete protein.
AK172807 - Homo sapiens cDNA FLJ23968 fis, clone HEP16755.
AL117662 - Homo sapiens mRNA; cDNA DKFZp586K0524 (from clone DKFZp586K0524); partial cds.
JD256421 - Sequence 237445 from Patent EP1572962.
JD210223 - Sequence 191247 from Patent EP1572962.
JD384668 - Sequence 365692 from Patent EP1572962.
JD323465 - Sequence 304489 from Patent EP1572962.
JD146868 - Sequence 127892 from Patent EP1572962.
JD252845 - Sequence 233869 from Patent EP1572962.
JD491764 - Sequence 472788 from Patent EP1572962.
JD060868 - Sequence 41892 from Patent EP1572962.
JD560307 - Sequence 541331 from Patent EP1572962.
JD380978 - Sequence 362002 from Patent EP1572962.
JD455232 - Sequence 436256 from Patent EP1572962.
JD359874 - Sequence 340898 from Patent EP1572962.
JD038311 - Sequence 19335 from Patent EP1572962.
JD110942 - Sequence 91966 from Patent EP1572962.
JD307556 - Sequence 288580 from Patent EP1572962.
JD398193 - Sequence 379217 from Patent EP1572962.
JD183361 - Sequence 164385 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC026967, KIAA1748, NM_015457, NP_056272, Q2TGF0, Q6ZMF0, Q8TAK8, Q9C0B5, Q9H923, Q9UFI7, ZDHC5_HUMAN, ZNF375
UCSC ID: uc001nky.1
RefSeq Accession: NM_015457
Protein: Q9C0B5 (aka ZDHC5_HUMAN or ZDH5_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC026967.1
exon count: 11CDS single in 3' UTR: no RNA size: 2497
ORF size: 1989CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 4089.50frame shift in genome: no % Coverage: 99.28
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.