Human Gene CTNND1 (uc001nly.4) Description and Page Index
  Description: Homo sapiens catenin (cadherin-associated protein), delta 1 (CTNND1), transcript variant 8, mRNA.
RefSeq Summary (NM_001085464): This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: hg19 chr11:57,529,234-57,586,652 Size: 57,419 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr11:57,569,218-57,583,780 Size: 14,563 Coding Exon Count: 14 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:57,529,234-57,586,652)mRNA (may differ from genome)Protein (639 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: CTNND1
Diseases sorted by gene-association score: pulmonary sclerosing hemangioma (10), sclerosing hemangioma (8), colon adenocarcinoma (7), sarcomatoid renal cell carcinoma (7), hemangioma of lung (6), epithelial malignant thymoma (6), cardiomyopathy, dilated, 1e (5), lung cancer (2), prostate cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 102.01 RPKM in Esophagus - Mucosa
Total median expression: 1795.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -94.70298-0.318 Picture PostScript Text
3' UTR -785.512872-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00514 - Armadillo/beta-catenin-like repeat

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on O60716-26
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  KJ806762 - Homo sapiens clone pSCaP_33.6_T7 satellite sequence.
AB002382 - Homo sapiens mRNA for KIAA0384 gene.
AK292554 - Homo sapiens cDNA FLJ75502 complete cds, highly similar to Homo sapiens catenin (cadherin-associated protein), delta 1, mRNA.
CR749275 - Homo sapiens mRNA; cDNA DKFZp781O2021 (from clone DKFZp781O2021).
AF062317 - Homo sapiens p120 catenin isoform 1B (CTNND1) mRNA, alternatively spliced, complete cds.
AF062318 - Homo sapiens p120 catenin isoform 4AC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062319 - Homo sapiens p120 catenin isoform 2ABC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062320 - Homo sapiens p120 catenin isoform 2AC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062321 - Homo sapiens p120 catenin isoform 1AC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062322 - Homo sapiens p120 catenin isoform 2AB (CTNND1) mRNA, alternatively spliced, complete cds.
AF062323 - Homo sapiens p120 catenin isoform 3ABC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062324 - Homo sapiens p120 catenin isoform 1A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062325 - Homo sapiens p120 catenin isoform 2B (CTNND1) mRNA, alternatively spliced, complete cds.
AF062326 - Homo sapiens p120 catenin isoform 4AB (CTNND1) mRNA, alternatively spliced, complete cds.
AF062327 - Homo sapiens p120 catenin isoform 2A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062328 - Homo sapiens p120 catenin isoform 1AB (CTNND1) mRNA, alternatively spliced, complete cds.
AF062329 - Homo sapiens p120 catenin isoform 2A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062330 - Homo sapiens p120 catenin isoform 3A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062331 - Homo sapiens p120 catenin isoform 2A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062332 - Homo sapiens p120 catenin isoform 3B (CTNND1) mRNA, alternatively spliced, complete cds.
AF062333 - Homo sapiens p120 catenin isoform 4A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062334 - Homo sapiens p120 catenin isoform 3A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062335 - Homo sapiens p120 catenin isoform 3A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062336 - Homo sapiens p120 catenin isoform 3A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062337 - Homo sapiens p120 catenin isoform 3AC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062338 - Homo sapiens p120 catenin isoform 3AB (CTNND1) mRNA, alternatively spliced, complete cds.
AF062339 - Homo sapiens p120 catenin isoform 1A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062340 - Homo sapiens p120 catenin isoform 4A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062341 - Homo sapiens p120 catenin isoform 1ABC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062342 - Homo sapiens p120 catenin isoform 4ABC (CTNND1) mRNA, alternatively spliced, complete cds.
AF062343 - Homo sapiens p120 catenin isoform 1A (CTNND1) mRNA, alternatively spliced, complete cds.
AF062344 - Homo sapiens p120 catenin isoform 4B (CTNND1) mRNA, alternatively spliced, complete cds.
BC075795 - Homo sapiens catenin (cadherin-associated protein), delta 1, mRNA (cDNA clone MGC:87286 IMAGE:5269008), complete cds.
JD281344 - Sequence 262368 from Patent EP1572962.
JD308850 - Sequence 289874 from Patent EP1572962.
AB385320 - Synthetic construct DNA, clone: pF1KA0384, Homo sapiens CTNND1 gene for catenin delta-1, complete cds, without stop codon, in Flexi system.
BC010501 - Homo sapiens catenin (cadherin-associated protein), delta 1, mRNA (cDNA clone IMAGE:3450203), partial cds.
KJ901366 - Synthetic construct Homo sapiens clone ccsbBroadEn_10760 CTNND1 gene, encodes complete protein.
CU679729 - Synthetic construct Homo sapiens gateway clone IMAGE:100023475 5' read CTNND1 mRNA.
BT007333 - Homo sapiens catenin (cadherin-associated protein), delta 1 mRNA, complete cds.
JD062366 - Sequence 43390 from Patent EP1572962.
JD563064 - Sequence 544088 from Patent EP1572962.
JD318823 - Sequence 299847 from Patent EP1572962.
JD558091 - Sequence 539115 from Patent EP1572962.
JD397618 - Sequence 378642 from Patent EP1572962.
JD555005 - Sequence 536029 from Patent EP1572962.
JD120323 - Sequence 101347 from Patent EP1572962.
JD270022 - Sequence 251046 from Patent EP1572962.
JD534169 - Sequence 515193 from Patent EP1572962.
JD307313 - Sequence 288337 from Patent EP1572962.
Z36799 - H.sapiens (xs148) mRNA, 250bp.
JD120222 - Sequence 101246 from Patent EP1572962.
JD453907 - Sequence 434931 from Patent EP1572962.
JD240700 - Sequence 221724 from Patent EP1572962.
JD111199 - Sequence 92223 from Patent EP1572962.
JD253550 - Sequence 234574 from Patent EP1572962.
JD555011 - Sequence 536035 from Patent EP1572962.
JD433160 - Sequence 414184 from Patent EP1572962.
JD439765 - Sequence 420789 from Patent EP1572962.
JD305951 - Sequence 286975 from Patent EP1572962.
JD159768 - Sequence 140792 from Patent EP1572962.
JD295980 - Sequence 277004 from Patent EP1572962.
JD040599 - Sequence 21623 from Patent EP1572962.
JD549221 - Sequence 530245 from Patent EP1572962.
JD551432 - Sequence 532456 from Patent EP1572962.
JD326346 - Sequence 307370 from Patent EP1572962.
JD403741 - Sequence 384765 from Patent EP1572962.
JD553807 - Sequence 534831 from Patent EP1572962.
JD172488 - Sequence 153512 from Patent EP1572962.
JD075604 - Sequence 56628 from Patent EP1572962.
JD145511 - Sequence 126535 from Patent EP1572962.
JD239577 - Sequence 220601 from Patent EP1572962.
JD330039 - Sequence 311063 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04520 - Adherens junction
hsa04670 - Leukocyte transendothelial migration

Reactome (by CSHL, EBI, and GO)

Protein O60716 (Reactome details) participates in the following event(s):

R-HSA-419002 Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin
R-HSA-8876993 CBLL1 binds SRC-phosphorylated CDH1 complex
R-HSA-5357477 PAK1-3 phosphorylates VE-cadherin
R-HSA-8876497 InlA binds CDH1
R-HSA-418990 Adherens junctions interactions
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-421270 Cell-cell junction organization
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-446728 Cell junction organization
R-HSA-5663205 Infectious disease
R-HSA-194138 Signaling by VEGF
R-HSA-1500931 Cell-Cell communication
R-HSA-1643685 Disease
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: AF062326, KIAA0384, NM_001085464, NP_001078933, O60716-26
UCSC ID: uc001nly.4
RefSeq Accession: NM_001085464
Protein: O60716-26, splice isoform of O60716

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AF062326.1
exon count: 15CDS single in 3' UTR: no RNA size: 5053
ORF size: 1920CDS single in intron: no Alignment % ID: 99.86
txCdsPredict score: 3271.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.