Human Gene DIXDC1 (uc001pml.3) Description and Page Index
Description: Homo sapiens DIX domain containing 1 (DIXDC1), transcript variant 1, mRNA. RefSeq Summary (NM_001037954): The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. Transcript (Including UTRs) Position: hg19 chr11:111,807,927-111,893,307 Size: 85,381 Total Exon Count: 21 Strand: + Coding Region Position: hg19 chr11:111,808,224-111,889,760 Size: 81,537 Coding Exon Count: 21
ID:DIXC1_HUMAN DESCRIPTION: RecName: Full=Dixin; AltName: Full=Coiled-coil protein DIX1; Short=Coiled-coil-DIX1; AltName: Full=DIX domain-containing protein 1; FUNCTION: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. SUBUNIT: Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin. INTERACTION: Q60838:Dvl2 (xeno); NbExp=4; IntAct=EBI-1104700, EBI-641940; SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. SUBCELLULAR LOCATION: Isoform 1: Cell junction, focal adhesion. Note=Associated with actin stress fiber at the filament ends. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in cardiac and skeletal muscles. DOMAIN: The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4. DOMAIN: The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling. PTM: Phosphorylated on tyrosine and serine residues. PTM: Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation. SIMILARITY: Belongs to the DIXDC1 family. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 DIX domain. SEQUENCE CAUTION: Sequence=AAH35509.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH64479.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB21826.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB71039.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q155Q3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.