Human Gene TSPAN9 (uc001qlp.3) Description and Page Index
Description: Homo sapiens tetraspanin 9 (TSPAN9), transcript variant 1, mRNA. RefSeq Summary (NM_006675): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009]. Transcript (Including UTRs) Position: hg19 chr12:3,186,521-3,395,730 Size: 209,210 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr12:3,310,360-3,392,282 Size: 81,923 Coding Exon Count: 7
ID:TSN9_HUMAN DESCRIPTION: RecName: Full=Tetraspanin-9; Short=Tspan-9; AltName: Full=Tetraspan NET-5; SUBUNIT: Found in a complex with GP6 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface (By similarity). TISSUE SPECIFICITY: Expressed in megakaryocytes and platelets (at protein level). PTM: Glycosylated (By similarity). SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TSPAN9 CDC HuGE Published Literature: TSPAN9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75954
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.