Human Gene TMEM194A (uc001smy.3) Description and Page Index
  Description: Homo sapiens transmembrane protein 194A (TMEM194A), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:57,449,426-57,472,574 Size: 23,149 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr12:57,453,662-57,472,528 Size: 18,867 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:57,449,426-57,472,574)mRNA (may differ from genome)Protein (444 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: T194A_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 194A;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM194 family.
SEQUENCE CAUTION: Sequence=AAH71597.1; Type=Erroneous initiation; Sequence=BAA22955.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.80 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 213.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.4046-0.335 Picture PostScript Text
3' UTR -1180.274236-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019358 - TMEM194

Pfam Domains:
PF10225 - NEMP family

ModBase Predicted Comparative 3D Structure on O14524
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ893355 - Synthetic construct Homo sapiens clone ccsbBroadEn_02749 TMEM194A gene, encodes complete protein.
CR749406 - Homo sapiens mRNA; cDNA DKFZp686N1768 (from clone DKFZp686N1768).
AB006624 - Homo sapiens mRNA for KIAA0286 gene.
AL833310 - Homo sapiens mRNA; cDNA DKFZp313B107 (from clone DKFZp313B107).
AL833311 - Homo sapiens mRNA; cDNA DKFZp313C037 (from clone DKFZp313C037).
JD038785 - Sequence 19809 from Patent EP1572962.
JD168099 - Sequence 149123 from Patent EP1572962.
JD283701 - Sequence 264725 from Patent EP1572962.
JD314397 - Sequence 295421 from Patent EP1572962.
JD361022 - Sequence 342046 from Patent EP1572962.
BC071597 - Homo sapiens transmembrane protein 194A, mRNA (cDNA clone IMAGE:30344897), partial cds.
JD082857 - Sequence 63881 from Patent EP1572962.
JD314286 - Sequence 295310 from Patent EP1572962.
JD345858 - Sequence 326882 from Patent EP1572962.
JD291828 - Sequence 272852 from Patent EP1572962.
JD349174 - Sequence 330198 from Patent EP1572962.
JD296687 - Sequence 277711 from Patent EP1572962.
JD330895 - Sequence 311919 from Patent EP1572962.
JD252166 - Sequence 233190 from Patent EP1572962.
JD166963 - Sequence 147987 from Patent EP1572962.
JD455832 - Sequence 436856 from Patent EP1572962.
JD352650 - Sequence 333674 from Patent EP1572962.
JD095422 - Sequence 76446 from Patent EP1572962.
JD399822 - Sequence 380846 from Patent EP1572962.
JD392852 - Sequence 373876 from Patent EP1572962.
JD549085 - Sequence 530109 from Patent EP1572962.
JD467474 - Sequence 448498 from Patent EP1572962.
JD231371 - Sequence 212395 from Patent EP1572962.
JD204747 - Sequence 185771 from Patent EP1572962.
JD296617 - Sequence 277641 from Patent EP1572962.
JD450430 - Sequence 431454 from Patent EP1572962.
JD202755 - Sequence 183779 from Patent EP1572962.
JD375028 - Sequence 356052 from Patent EP1572962.
JD506844 - Sequence 487868 from Patent EP1572962.
JD234593 - Sequence 215617 from Patent EP1572962.
JD192361 - Sequence 173385 from Patent EP1572962.
JD145969 - Sequence 126993 from Patent EP1572962.
JD552588 - Sequence 533612 from Patent EP1572962.
JD319101 - Sequence 300125 from Patent EP1572962.
JD508152 - Sequence 489176 from Patent EP1572962.
JD176297 - Sequence 157321 from Patent EP1572962.
JD553134 - Sequence 534158 from Patent EP1572962.
JD553133 - Sequence 534157 from Patent EP1572962.
JD347996 - Sequence 329020 from Patent EP1572962.
JD161892 - Sequence 142916 from Patent EP1572962.
JD197463 - Sequence 178487 from Patent EP1572962.
JD409796 - Sequence 390820 from Patent EP1572962.
JD058469 - Sequence 39493 from Patent EP1572962.
JD565485 - Sequence 546509 from Patent EP1572962.
JD256305 - Sequence 237329 from Patent EP1572962.
JD122899 - Sequence 103923 from Patent EP1572962.
JD556668 - Sequence 537692 from Patent EP1572962.
JD147387 - Sequence 128411 from Patent EP1572962.
JD382679 - Sequence 363703 from Patent EP1572962.
JD319100 - Sequence 300124 from Patent EP1572962.
JD250293 - Sequence 231317 from Patent EP1572962.
JD304869 - Sequence 285893 from Patent EP1572962.
JD449786 - Sequence 430810 from Patent EP1572962.
BC117436 - Homo sapiens transmembrane protein 194A, mRNA (cDNA clone MGC:151045 IMAGE:40125987), complete cds.
BC126300 - Homo sapiens transmembrane protein 194A, mRNA (cDNA clone MGC:161578 IMAGE:8992016), complete cds.
BC144029 - Homo sapiens cDNA clone IMAGE:9052549, with apparent retained intron.
AK294566 - Homo sapiens cDNA FLJ53781 complete cds.
JD532824 - Sequence 513848 from Patent EP1572962.
JD263377 - Sequence 244401 from Patent EP1572962.
JD286498 - Sequence 267522 from Patent EP1572962.
JD512438 - Sequence 493462 from Patent EP1572962.
AB383838 - Synthetic construct DNA, clone: pF1KSDA0286, Homo sapiens KIAA0286 gene for KIAA0286 protein, complete cds, without stop codon, in Flexi system.
HQ258223 - Synthetic construct Homo sapiens clone IMAGE:100072532 transmembrane protein 194A (TMEM194A), transcript variant 2 (TMEM194A) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0286, NM_001130963, NP_001124435, O14524, Q17R72, Q68DH0, Q6IQ25, T194A_HUMAN, TMEM194
UCSC ID: uc001smy.3
RefSeq Accession: NM_001130963
Protein: O14524 (aka T194A_HUMAN)
CCDS: CCDS44927.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001130963.1
exon count: 9CDS single in 3' UTR: no RNA size: 5632
ORF size: 1335CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2870.00frame shift in genome: no % Coverage: 99.73
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.