Human Gene RHOF (uc001ubd.4) Description and Page Index
  Description: Homo sapiens ras homolog family member F (in filopodia) (RHOF), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:122,218,393-122,231,594 Size: 13,202 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr12:122,218,736-122,231,539 Size: 12,804 Coding Exon Count: 4 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:122,218,393-122,231,594)mRNA (may differ from genome)Protein (170 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIPubMed
ReactomeStanford SOURCEUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RHOF
CDC HuGE Published Literature: RHOF
Positive Disease Associations: Cholesterol, HDL , Erythrocytes
Related Studies:
  1. Cholesterol, HDL
    , , . [PubMed 0]
  2. Erythrocytes
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: RHOF
Diseases sorted by gene-association score: charcot-marie-tooth disease, axonal, type 2l (2), malaria (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.72 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 64.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.2055-0.531 Picture PostScript Text
3' UTR -108.80343-0.317 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9HBH0-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK000254 - Homo sapiens cDNA FLJ20247 fis, clone COLF6493.
AF239923 - Homo sapiens Rho family small GTPase (RIF) mRNA, complete cds.
AK289482 - Homo sapiens cDNA FLJ75043 complete cds, highly similar to Homo sapiens ras homolog gene family, member F (in filopodia), mRNA.
BC018208 - Homo sapiens ras homolog gene family, member F (in filopodia), mRNA (cDNA clone MGC:8870 IMAGE:3864426), complete cds.
KJ902654 - Synthetic construct Homo sapiens clone ccsbBroadEn_12048 RHOF gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9HBH0 (Reactome details) participates in the following event(s):

R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-195146 Dissociation of Rho GTP:GDP from GDI complex
R-HSA-194894 Rho GTPase:GTP activates downstream effectors
R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-194913 GEFs activate Rho GTPase:GDP
R-HSA-194854 GDIs block activation of Rho GTPase:GDP
R-HSA-6798695 Neutrophil degranulation
R-HSA-194840 Rho GTPase cycle
R-HSA-168249 Innate Immune System
R-HSA-194315 Signaling by Rho GTPases
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ARHF, BC018208, NM_019034, NP_061907, Q9HBH0-2, RIF
UCSC ID: uc001ubd.4
RefSeq Accession: NM_019034
Protein: Q9HBH0-2, splice isoform of Q9HBH0

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC018208.1
exon count: 4CDS single in 3' UTR: no RNA size: 661
ORF size: 513CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1088.00frame shift in genome: no % Coverage: 97.13
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 385# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.