Human Gene FRY (uc001utx.3) Description and Page Index
  Description: Homo sapiens furry homolog (Drosophila) (FRY), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr13:32,605,437-32,870,776 Size: 265,340 Total Exon Count: 61 Strand: +
Coding Region
   Position: hg19 chr13:32,605,933-32,869,597 Size: 263,665 Coding Exon Count: 61 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr13:32,605,437-32,870,776)mRNA (may differ from genome)Protein (3013 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein furry homolog;
FUNCTION: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
SUBUNIT: When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.
PTM: Phosphorylated by AURKA, CDK1 and PLK1.
SIMILARITY: Belongs to the furry protein family.
SEQUENCE CAUTION: Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FRY
CDC HuGE Published Literature: FRY
Positive Disease Associations: Body Fat Distribution , Fibrinogen , Thyrotropin
Related Studies:
  1. Body Fat Distribution
    , , . [PubMed 0]
  2. Fibrinogen
    , , . [PubMed 0]
  3. Thyrotropin
    Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics. [PubMed 17903292]
    Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.83 RPKM in Artery - Tibial
Total median expression: 260.16 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -238.45496-0.481 Picture PostScript Text
3' UTR -291.161179-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025614 - Cell_morpho_N
IPR025481 - Cell_Morphogen_C

Pfam Domains:
PF14222 - Cell morphogenesis N-terminal
PF14225 - Cell morphogenesis C-terminal
PF14228 - Cell morphogenesis central region

ModBase Predicted Comparative 3D Structure on Q5TBA9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004857 enzyme inhibitor activity

Biological Process:
GO:0000902 cell morphogenesis
GO:0031175 neuron projection development
GO:0043086 negative regulation of catalytic activity
GO:0090527 actin filament reorganization
GO:1904428 negative regulation of tubulin deacetylation

Cellular Component:
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0030427 site of polarized growth

-  Descriptions from all associated GenBank mRNAs
  U50534 - Human BRCA2 region, mRNA sequence CG003.
AL049784 - Novel human gene mapping to chomosome 13.
BC172204 - Synthetic construct Homo sapiens clone IMAGE:9094355 furry homolog (FRY) gene, partial cds.
BC172205 - Synthetic construct Homo sapiens clone IMAGE:9094357 furry homolog (FRY) gene, partial cds.
JD515579 - Sequence 496603 from Patent EP1572962.
JD038368 - Sequence 19392 from Patent EP1572962.
JD205218 - Sequence 186242 from Patent EP1572962.
JD450396 - Sequence 431420 from Patent EP1572962.
JD447965 - Sequence 428989 from Patent EP1572962.
JD199085 - Sequence 180109 from Patent EP1572962.
AK091422 - Homo sapiens cDNA FLJ34103 fis, clone FCBBF3007859, moderately similar to Human putative protein B2 mRNA.
BX537670 - Homo sapiens mRNA; cDNA DKFZp686K08123 (from clone DKFZp686K08123).
AK298021 - Homo sapiens cDNA FLJ58597 complete cds.
U57961 - Human infant brain mRNA, clone 13cDNA73.
JD045252 - Sequence 26276 from Patent EP1572962.
JD432079 - Sequence 413103 from Patent EP1572962.
JD218751 - Sequence 199775 from Patent EP1572962.
JD103422 - Sequence 84446 from Patent EP1572962.
JD273284 - Sequence 254308 from Patent EP1572962.
JD042791 - Sequence 23815 from Patent EP1572962.
JD411192 - Sequence 392216 from Patent EP1572962.
JD437176 - Sequence 418200 from Patent EP1572962.
JD428665 - Sequence 409689 from Patent EP1572962.
JD545782 - Sequence 526806 from Patent EP1572962.
JD410037 - Sequence 391061 from Patent EP1572962.
JD330483 - Sequence 311507 from Patent EP1572962.
JD045494 - Sequence 26518 from Patent EP1572962.
JD291967 - Sequence 272991 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C13orf14, FRY_HUMAN, NM_023037, NP_075463, Q5TBA9, Q9Y3N6
UCSC ID: uc001utx.3
RefSeq Accession: NM_023037
Protein: Q5TBA9 (aka FRY_HUMAN)
CCDS: CCDS41875.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_023037.2
exon count: 61CDS single in 3' UTR: no RNA size: 10718
ORF size: 9042CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 15650.00frame shift in genome: no % Coverage: 99.99
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.