Human Gene EXOSC8 (uc001uvz.2) Description and Page Index
  Description: Homo sapiens exosome component 8 (EXOSC8), mRNA.
RefSeq Summary (NM_181503): This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.117613.1, SRR1803613.75381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000389704.4/ ENSP00000374354.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr13:37,574,678-37,582,972 Size: 8,295 Total Exon Count: 11 Strand: +


Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:37,574,678-37,582,972)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneNetworkH-INV
HGNCLynxPubMedStanford SOURCETreefamWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: EXOSC8
Diseases sorted by gene-association score: pontocerebellar hypoplasia, type 1c* (1300), pontocerebellar hypoplasia type 1* (175), pontocerebellar hypoplasia (10)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.60 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 407.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  KJ898406 - Synthetic construct Homo sapiens clone ccsbBroadEn_07800 EXOSC8 gene, encodes complete protein.
AK096810 - Homo sapiens cDNA FLJ39491 fis, clone PROST2015924, weakly similar to Homo sapiens Opa-interacting protein OIP2 mRNA.
BC020773 - Homo sapiens exosome component 8, mRNA (cDNA clone MGC:22685 IMAGE:4808747), complete cds.
AL050353 - Homo sapiens mRNA; cDNA DKFZp564C0482 (from clone DKFZp564C0482).
AF279901 - Homo sapiens PNAS-147 mRNA, partial sequence.
AB463623 - Synthetic construct DNA, clone: pF1KB6391, Homo sapiens EXOSC8 gene for exosome component 8, without stop codon, in Flexi system.
DQ896414 - Synthetic construct Homo sapiens clone IMAGE:100010874; FLH194102.01L; RZPDo839F0669D exosome component 8 (EXOSC8) gene, encodes complete protein.
DQ893134 - Synthetic construct clone IMAGE:100005764; FLH194106.01X; RZPDo839F0679D exosome component 8 (EXOSC8) gene, encodes complete protein.
AF025438 - Homo sapiens Opa-interacting protein OIP2 mRNA, partial cds.
AK126602 - Homo sapiens cDNA FLJ44639 fis, clone BRACE2027382, highly similar to Homo sapiens Opa-interacting protein OIP2.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03018 - RNA degradation

-  Other Names for This Gene
  Alternate Gene Symbols: AF279901
UCSC ID: uc001uvz.2
RefSeq Accession: NM_181503

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: AF279901.1
exon count: 11CDS single in 3' UTR: no RNA size: 798
ORF size: 0CDS single in intron: no Alignment % ID: 99.49
txCdsPredict score: 81.00frame shift in genome: no % Coverage: 95.61
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.