Human Gene EXOSC8 (uc001uvz.2) Description and Page Index
Description: Homo sapiens exosome component 8 (EXOSC8), mRNA. RefSeq Summary (NM_181503): This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.117613.1, SRR1803613.75381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000389704.4/ ENSP00000374354.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr13:37,574,678-37,582,972 Size: 8,295 Total Exon Count: 11 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
KJ898406 - Synthetic construct Homo sapiens clone ccsbBroadEn_07800 EXOSC8 gene, encodes complete protein. AK096810 - Homo sapiens cDNA FLJ39491 fis, clone PROST2015924, weakly similar to Homo sapiens Opa-interacting protein OIP2 mRNA. BC020773 - Homo sapiens exosome component 8, mRNA (cDNA clone MGC:22685 IMAGE:4808747), complete cds. AL050353 - Homo sapiens mRNA; cDNA DKFZp564C0482 (from clone DKFZp564C0482). AF279901 - Homo sapiens PNAS-147 mRNA, partial sequence. AB463623 - Synthetic construct DNA, clone: pF1KB6391, Homo sapiens EXOSC8 gene for exosome component 8, without stop codon, in Flexi system. DQ896414 - Synthetic construct Homo sapiens clone IMAGE:100010874; FLH194102.01L; RZPDo839F0669D exosome component 8 (EXOSC8) gene, encodes complete protein. DQ893134 - Synthetic construct clone IMAGE:100005764; FLH194106.01X; RZPDo839F0679D exosome component 8 (EXOSC8) gene, encodes complete protein. AF025438 - Homo sapiens Opa-interacting protein OIP2 mRNA, partial cds. AK126602 - Homo sapiens cDNA FLJ44639 fis, clone BRACE2027382, highly similar to Homo sapiens Opa-interacting protein OIP2.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03018 - RNA degradation