Human Gene FOS (uc001xrn.3) Description and Page Index
  Description: Homo sapiens FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA.
RefSeq Summary (NM_005252): The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX647104.1, SRR3476690.806825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303562.9/ ENSP00000306245.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr14:75,745,481-75,748,937 Size: 3,457 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr14:75,745,686-75,748,127 Size: 2,442 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:75,745,481-75,748,937)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Proto-oncogene c-Fos; AltName: Full=Cellular oncogene fos; AltName: Full=G0/G1 switch regulatory protein 7;
FUNCTION: Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
SUBUNIT: Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
INTERACTION: P05067:APP; NbExp=3; IntAct=EBI-852851, EBI-77613; P15336:ATF2; NbExp=4; IntAct=EBI-852851, EBI-1170906; P10909:CLU; NbExp=2; IntAct=EBI-852851, EBI-1104674; Q9BT78:COPS4; NbExp=2; IntAct=EBI-852851, EBI-742413; P05412:JUN; NbExp=6; IntAct=EBI-852851, EBI-852823; P17535:JUND; NbExp=3; IntAct=EBI-852851, EBI-2682803; P52736:ZNF133; NbExp=4; IntAct=EBI-852851, EBI-2687350;
PTM: Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
PTM: Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
SIMILARITY: Belongs to the bZIP family. Fos subfamily.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FOS
CDC HuGE Published Literature: FOS
Positive Disease Associations: Glucose
Related Studies:
  1. Glucose
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: FOS
Diseases sorted by gene-association score: acute pericementitis (15), pertussis (13), fibrodysplasia ossificans progressiva (13), cerebral hypoxia (12), myositis ossificans (10), fumarate hydratase deficiency (9), leber congenital amaurosis 6 (8), audiogenic seizures (8), status epilepticus (7), withdrawal disorder (7), coffin-lowry syndrome (7), ocular hypertension (6), malignant fibrous histiocytoma of bone (6), breast adenocarcinoma (6), marcus gunn phenomenon (6), motion sickness (6), testicular leukemia (5), glycogen storage disease vi (5), morphine dependence (5), juxtacortical osteosarcoma (5), periosteal osteogenic sarcoma (5), malignant histiocytosis (5), photokeratitis (5), lymph node cancer (5), peripheral osteosarcoma (4), occlusion precerebral artery (4), space motion sickness (4), amnestic disorder (4), patellofemoral pain syndrome (4), disuse amblyopia (4), osteoporosis (4), endometrial cancer (4), amyotrophic lateral sclerosis 9 (4), drug-induced mental disorder (3), drug psychosis (3), transient global amnesia (3), amyotrophic lateral sclerosis 7 (3), colorectal cancer (3), rheumatoid arthritis (3), breast cancer (3), osteosarcoma, somatic (2), attention deficit-hyperactivity disorder (2), pheochromocytoma (2), pain agnosia (1), agnosia (1), disease of mental health (1), thyroid cancer, nonmedullary, 2 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 814.02 RPKM in Fallopian Tube
Total median expression: 4887.05 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.50205-0.329 Picture PostScript Text
3' UTR -232.70810-0.287 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR000837 - Leuzip_Fos

Pfam Domains:
PF00170 - bZIP transcription factor
PF03131 - bZIP Maf transcription factor
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

- X-ray MuPIT

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P01100
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0070412 R-SMAD binding

Biological Process:
GO:0001661 conditioned taste aversion
GO:0006306 DNA methylation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0009409 response to cold
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009629 response to gravity
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0019221 cytokine-mediated signaling pathway
GO:0030431 sleep
GO:0031668 cellular response to extracellular stimulus
GO:0032496 response to lipopolysaccharide
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0034614 cellular response to reactive oxygen species
GO:0035902 response to immobilization stress
GO:0035914 skeletal muscle cell differentiation
GO:0035994 response to muscle stretch
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0060395 SMAD protein signal transduction
GO:0071276 cellular response to cadmium ion
GO:0071277 cellular response to calcium ion
GO:1901216 positive regulation of neuron death
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0032993 protein-DNA complex
GO:0035976 transcription factor AP-1 complex
GO:0043005 neuron projection

-  Descriptions from all associated GenBank mRNAs
  KP790138 - Homo sapiens FOS/VIM fusion protein (FOS/VIM) mRNA, partial cds.
LF212504 - JP 2014500723-A/20007: Polycomb-Associated Non-Coding RNAs.
LF209606 - JP 2014500723-A/17109: Polycomb-Associated Non-Coding RNAs.
AK291326 - Homo sapiens cDNA FLJ76842 complete cds, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA.
AK298659 - Homo sapiens cDNA FLJ55132 complete cds, highly similar to Proto-oncogene protein c-fos.
AK097379 - Homo sapiens cDNA FLJ40060 fis, clone TCOLN2000236, highly similar to Proto-oncogene protein c-fos.
BX647104 - Homo sapiens mRNA; cDNA DKFZp686J04124 (from clone DKFZp686J04124).
LF213788 - JP 2014500723-A/21291: Polycomb-Associated Non-Coding RNAs.
BC004490 - Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog, mRNA (cDNA clone MGC:11074 IMAGE:3688670), complete cds.
AH003773 - Homo sapiens FOS (c-fos) mRNA, complete cds.
DQ893444 - Synthetic construct clone IMAGE:100006074; FLH199535.01X; RZPDo839H0882D v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) gene, encodes complete protein.
DQ896750 - Synthetic construct Homo sapiens clone IMAGE:100011210; FLH199442.01L; RZPDo839H0881D v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) gene, encodes complete protein.
CU678740 - Synthetic construct Homo sapiens gateway clone IMAGE:100019160 5' read FOS mRNA.
AB385594 - Synthetic construct DNA, clone: pF1KB9574, Homo sapiens FOS gene for proto-oncogene protein c-fos, complete cds, without stop codon, in Flexi system.
CR541785 - Homo sapiens full open reading frame cDNA clone RZPDo834H0730D for gene FOS, v-fos FBJ murine osteosarcoma viral oncogene homolog; complete cds, without stopcodon.
CR542267 - Homo sapiens full open reading frame cDNA clone RZPDo834H0326D for gene FOS, v-fos FBJ murine osteosarcoma viral oncogene homolog; complete cds, incl. stopcodon.
KJ896826 - Synthetic construct Homo sapiens clone ccsbBroadEn_06220 FOS gene, encodes complete protein.
AK290907 - Homo sapiens cDNA FLJ77786 complete cds.
LF330109 - JP 2014500723-A/137612: Polycomb-Associated Non-Coding RNAs.
KP790139 - Homo sapiens FOS/RP11-326N17.1 fusion protein (FOS/RP11-326N17.1) mRNA, partial cds.
KP790137 - Homo sapiens FOS/MBNL1 fusion protein (FOS/MBNL1) mRNA, partial cds.
LF330111 - JP 2014500723-A/137614: Polycomb-Associated Non-Coding RNAs.
JD484093 - Sequence 465117 from Patent EP1572962.
JD173178 - Sequence 154202 from Patent EP1572962.
JD280612 - Sequence 261636 from Patent EP1572962.
JD188159 - Sequence 169183 from Patent EP1572962.
JD433247 - Sequence 414271 from Patent EP1572962.
JD349932 - Sequence 330956 from Patent EP1572962.
BD269368 - Gene showing enhanced expression in association with aging of cells and final differentiation of cells and utilization thereof.
JD494766 - Sequence 475790 from Patent EP1572962.
LF330112 - JP 2014500723-A/137615: Polycomb-Associated Non-Coding RNAs.
MA565686 - JP 2018138019-A/137612: Polycomb-Associated Non-Coding RNAs.
MA565688 - JP 2018138019-A/137614: Polycomb-Associated Non-Coding RNAs.
MA565689 - JP 2018138019-A/137615: Polycomb-Associated Non-Coding RNAs.
MA448081 - JP 2018138019-A/20007: Polycomb-Associated Non-Coding RNAs.
MA445183 - JP 2018138019-A/17109: Polycomb-Associated Non-Coding RNAs.
MA449365 - JP 2018138019-A/21291: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04620 - Toll-like receptor signaling pathway
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa05140 - Leishmaniasis
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer

Reactome (by CSHL, EBI, and GO)

Protein P01100 (Reactome details) participates in the following event(s):

R-HSA-450325 c-FOS activation by phospho ERK1/2
R-HSA-450292 Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
R-HSA-3222533 ERK1/2-activated AP1 complex binds KDM6B promoter
R-HSA-3797196 AP-1 transcription factor binds IGFBP7 promoter
R-HSA-4568737 AP-1 transcription factor binds IL1A promoter
R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter
R-HSA-6806412 TP53 and AP-1 bind the MSH2 promoter
R-HSA-450341 Activation of the AP-1 family of transcription factors
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-2559583 Cellular Senescence
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-2262752 Cellular responses to stress
R-HSA-168249 Innate Immune System
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-8939211 ESR-mediated signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-168256 Immune System
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-212436 Generic Transcription Pathway
R-HSA-162582 Signal Transduction
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: FOS_HUMAN, G0S7, NM_005252, NP_005243, P01100, P18849
UCSC ID: uc001xrn.3
RefSeq Accession: NM_005252
Protein: P01100 (aka FOS_HUMAN)
CCDS: CCDS9841.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_005252.3
exon count: 4CDS single in 3' UTR: no RNA size: 2158
ORF size: 1143CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2486.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.