Human Gene C14orf159 (uc001xzc.2) Description and Page Index
  Description: Homo sapiens chromosome 14 open reading frame 159 (C14orf159), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:91,580,357-91,691,703 Size: 111,347 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr14:91,626,639-91,691,177 Size: 64,539 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:91,580,357-91,691,703)mRNA (may differ from genome)Protein (616 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
Stanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=UPF0317 protein C14orf159, mitochondrial; Flags: Precursor;
SUBCELLULAR LOCATION: Mitochondrion (Potential).
SIMILARITY: Belongs to the UPF0317 family.
SEQUENCE CAUTION: Sequence=BAB14932.1; Type=Frameshift; Positions=436, 582;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C14orf159
CDC HuGE Published Literature: C14orf159

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.15 RPKM in Heart - Left Ventricle
Total median expression: 485.66 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -221.78597-0.371 Picture PostScript Text
3' UTR -157.30526-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009906 - DUF1445
IPR025504 - DUF4392
IPR017135 - UPF0317_mt

Pfam Domains:
PF07286 - Protein of unknown function (DUF1445)
PF14336 - Domain of unknown function (DUF4392)

ModBase Predicted Comparative 3D Structure on Q7Z3D6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0047820 D-glutamate cyclase activity

Biological Process:
GO:0006536 glutamate metabolic process
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

-  Descriptions from all associated GenBank mRNAs
  AK097294 - Homo sapiens cDNA FLJ39975 fis, clone SPLEN2028466.
AK098752 - Homo sapiens cDNA FLJ25886 fis, clone CBR02987.
BX537970 - Homo sapiens mRNA; cDNA DKFZp686J0759 (from clone DKFZp686J0759); complete cds.
BX161393 - human full-length cDNA clone CS0DC008YJ24 of Neuroblastoma of Homo sapiens (human).
BX247989 - human full-length cDNA clone CS0DG002YH18 of B cells (Ramos cell line) of Homo sapiens (human).
BC009182 - Homo sapiens chromosome 14 open reading frame 159, mRNA (cDNA clone IMAGE:3943486), complete cds.
AK308857 - Homo sapiens cDNA, FLJ98898.
AB210031 - Homo sapiens mRNA for C14orf159 variant protein, clone: hh05718.
AK023200 - Homo sapiens cDNA FLJ13138 fis, clone NT2RP3003197, weakly similar to HYPOTHETICAL 33.8 KD PROTEIN C5H10.01 IN CHROMOSOME I.
AK123532 - Homo sapiens cDNA FLJ41538 fis, clone BRTHA2018129.
BC065558 - Homo sapiens chromosome 14 open reading frame 159, mRNA (cDNA clone MGC:74715 IMAGE:6138321), complete cds.
BX248782 - human full-length cDNA 5-PRIME end of clone CS0DL008YE07 of B cells (Ramos cell line) of Homo sapiens (human).
AK091394 - Homo sapiens cDNA FLJ34075 fis, clone FCBBF3003216.
AK022564 - Homo sapiens cDNA FLJ12502 fis, clone NT2RM2001688, weakly similar to HYPOTHETICAL 33.8 KD PROTEIN C5H10.01 IN CHROMOSOME I.
BX248060 - human full-length cDNA clone CS0DJ004YG22 of T cells (Jurkat cell line) of Homo sapiens (human).
BC010614 - Homo sapiens chromosome 14 open reading frame 159, mRNA (cDNA clone MGC:16855 IMAGE:4157432), complete cds.
AY358516 - Homo sapiens clone DNA59774 PFTL2439 (UNQ2439) mRNA, complete cds.
JD347876 - Sequence 328900 from Patent EP1572962.
AM393118 - Synthetic construct Homo sapiens clone IMAGE:100001990 for hypothetical protein (C14orf159 gene).
KJ903267 - Synthetic construct Homo sapiens clone ccsbBroadEn_12661 C14orf159 gene, encodes complete protein.
CU679757 - Synthetic construct Homo sapiens gateway clone IMAGE:100020761 5' read C14orf159 mRNA.
AB384381 - Synthetic construct DNA, clone: pF1KSDB0052, Homo sapiens C14orf159 gene for chromosome 14 open reading frame protein 159, complete cds, without stop codon, in Flexi system.
CR457289 - Homo sapiens full open reading frame cDNA clone RZPDo834C0921D for gene C14orf159, chromosome 14 open reading frame 159; complete cds, incl. stopcodon.
KJ899604 - Synthetic construct Homo sapiens clone ccsbBroadEn_08998 C14orf159 gene, encodes complete protein.
BX248294 - human full-length cDNA clone CS0DJ010YP09 of T cells (Jurkat cell line) of Homo sapiens (human).
BC011545 - Homo sapiens mRNA similar to hypothetical protein FLJ20950 (cDNA clone IMAGE:4639229).
AK222531 - Homo sapiens mRNA for chromosome 14 open reading frame 159 variant, clone: adSE01927.
AK024603 - Homo sapiens cDNA: FLJ20950 fis, clone ADSE01927.
AY927602 - Homo sapiens mRNA sequence.
BX647492 - Homo sapiens mRNA; cDNA DKFZp686I02128 (from clone DKFZp686I02128).
AK097262 - Homo sapiens cDNA FLJ39943 fis, clone SPLEN2023118.
JD185171 - Sequence 166195 from Patent EP1572962.
JD307359 - Sequence 288383 from Patent EP1572962.
JD168701 - Sequence 149725 from Patent EP1572962.
JD308630 - Sequence 289654 from Patent EP1572962.
JD053157 - Sequence 34181 from Patent EP1572962.
JD225553 - Sequence 206577 from Patent EP1572962.
JD298703 - Sequence 279727 from Patent EP1572962.
JD089696 - Sequence 70720 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KUI7, CN159_HUMAN, NM_024952, NP_079228, Q7Z3D6, Q86SW3, Q86SX8, Q86SX9, Q86T08, Q86TV5, Q96GW5, Q9H7G0, Q9H8Y9, Q9H9W6, UNQ2439/PRO5000
UCSC ID: uc001xzc.2
RefSeq Accession: NM_024952
Protein: Q7Z3D6 (aka CN159_HUMAN or CMF9_HUMAN)
CCDS: CCDS32141.1, CCDS41979.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_024952.6
exon count: 14CDS single in 3' UTR: no RNA size: 2993
ORF size: 1851CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3436.00frame shift in genome: no % Coverage: 99.37
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.