Human Gene EIF2AK4 (uc001zkm.1) Description and Page Index
Description: Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), mRNA. RefSeq Summary (NM_001013703): This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology MANE Ensembl match :: ENST00000263791.10/ ENSP00000263791.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr15:40,226,347-40,327,797 Size: 101,451 Total Exon Count: 39 Strand: + Coding Region Position: hg19 chr15:40,226,397-40,327,285 Size: 100,889 Coding Exon Count: 39
ID:E2AK4_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 4; EC=18.104.22.168; AltName: Full=GCN2-like protein; FUNCTION: Can phosphorylate the alpha subunit of EIF2 and may mediate translational control (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. TISSUE SPECIFICITY: Widely expressed. DOMAIN: Kinase domain 1 is a degenerate kinase domain. DOMAIN: RWD domain is reported to interact with GCN1L1. PTM: Autophosphorylated on threonine residues (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. SIMILARITY: Contains 2 protein kinase domains. SIMILARITY: Contains 1 RWD domain. SEQUENCE CAUTION: Sequence=BAA92576.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=BAB15625.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF05773 - RWD domain PF07714 - Protein tyrosine kinase PF12745 - Anticodon binding domain of tRNAs PF13393 - Histidyl-tRNA synthetase
SCOP Domains: 52954 - Anticodon-binding domain of Class II aaRS 55681 - Class II aaRS and biotin synthetases 56112 - Protein kinase-like (PK-like) 54495 - UBC-like
ModBase Predicted Comparative 3D Structure on Q9P2K8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.