Human Gene MORF4L1 (uc002bel.4) Description and Page Index
  Description: Homo sapiens mortality factor 4 like 1 (MORF4L1), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:79,165,123-79,190,081 Size: 24,959 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr15:79,165,360-79,189,409 Size: 24,050 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:79,165,123-79,190,081)mRNA (may differ from genome)Protein (362 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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Wikipedia

-  Comments and Description Text from UniProtKB
  ID: MO4L1_HUMAN
DESCRIPTION: RecName: Full=Mortality factor 4-like protein 1; AltName: Full=MORF-related gene 15 protein; AltName: Full=Protein MSL3-1; AltName: Full=Transcription factor-like protein MRG15;
FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
SUBUNIT: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Contains 1 MRG domain.
SEQUENCE CAUTION: Sequence=AAG17253.1; Type=Frameshift; Positions=348, 360;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MORF4L1
CDC HuGE Published Literature: MORF4L1
Positive Disease Associations: Heart Rate
Related Studies:
  1. Heart Rate
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: MORF4L1
Diseases sorted by gene-association score: paraneoplastic cerebellar degeneration (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 111.42 RPKM in Testis
Total median expression: 3130.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -103.60237-0.437 Picture PostScript Text
3' UTR -156.17672-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016197 - Chromodomain-like
IPR017398 - EAF3/MRG15
IPR008676 - MRG
IPR026541 - MRG_dom
IPR025995 - Tudor-knot

Pfam Domains:
PF05712 - MRG
PF11717 - RNA binding activity-knot of a chromodomain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2AQL
- X-ray MuPIT

2EFI
- NMR MuPIT

2F5J
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2F5K - X-ray MuPIT 2LKM - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9UBU8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0047485 protein N-terminus binding

Biological Process:
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006342 chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0008283 cell proliferation
GO:0016575 histone deacetylation
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016580 Sin3 complex
GO:0016607 nuclear speck
GO:0035267 NuA4 histone acetyltransferase complex


-  Descriptions from all associated GenBank mRNAs
  AK095823 - Homo sapiens cDNA FLJ38504 fis, clone HCHON2000156, highly similar to Mortality factor 4-like protein 1.
AK098485 - Homo sapiens cDNA FLJ25619 fis, clone STM02419, highly similar to TRANSCRIPTION FACTOR-LIKE PROTEIN MORF4.
AF218011 - Homo sapiens clone PP368 unknown mRNA.
AF100615 - Homo sapiens chromosome 15 MRG15 protein (MRG15) mRNA, complete cds.
AY148481 - Homo sapiens putative transcription factor MRG15-2 (MRG15) mRNA, complete cds; alternatively spliced.
AK296650 - Homo sapiens cDNA FLJ50561 complete cds, highly similar to Mortality factor 4-like protein 1.
BC002936 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:10631 IMAGE:3955120), complete cds.
BC022845 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:1262 IMAGE:2988803), complete cds.
AK310702 - Homo sapiens cDNA, FLJ17744.
BC141840 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:166970 IMAGE:8860303), complete cds.
AF070664 - Homo sapiens HSPC008 mRNA, complete cds.
AF167173 - Homo sapiens chromosome X MSL3-1 protein mRNA, complete cds.
AK310592 - Homo sapiens cDNA, FLJ17634.
AL137697 - Homo sapiens mRNA; cDNA DKFZp566F194 (from clone DKFZp566F194).
AF109188 - Homo sapiens FWP006 mRNA, complete cds.
AF161546 - Homo sapiens HSPC061 mRNA, complete cds.
AK300789 - Homo sapiens cDNA FLJ50694 complete cds, highly similar to Mortality factor 4-like protein 1.
BC067826 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:87361 IMAGE:4824022), complete cds.
CU692730 - Synthetic construct Homo sapiens gateway clone IMAGE:100018923 5' read MORF4L1 mRNA.
AB385578 - Synthetic construct DNA, clone: pF1KB9446, Homo sapiens MORF4L1 gene for mortality factor 4-like protein 1, complete cds, without stop codon, in Flexi system.
DQ892602 - Synthetic construct clone IMAGE:100005232; FLH188135.01X; RZPDo839G10150D mortality factor 4 like 1 (MORF4L1) gene, encodes complete protein.
DQ895837 - Synthetic construct Homo sapiens clone IMAGE:100010297; FLH188131.01L; RZPDo839G10149D mortality factor 4 like 1 (MORF4L1) gene, encodes complete protein.
KJ893172 - Synthetic construct Homo sapiens clone ccsbBroadEn_02566 MORF4L1 gene, encodes complete protein.
AK310181 - Homo sapiens cDNA, FLJ17223.
JD024428 - Sequence 5452 from Patent EP1572962.
JD029863 - Sequence 10887 from Patent EP1572962.
JD025067 - Sequence 6091 from Patent EP1572962.
JD047852 - Sequence 28876 from Patent EP1572962.
JD034132 - Sequence 15156 from Patent EP1572962.
JD485891 - Sequence 466915 from Patent EP1572962.
JD215540 - Sequence 196564 from Patent EP1572962.
JD292630 - Sequence 273654 from Patent EP1572962.
AF131847 - Homo sapiens clone 24896 mRNA sequence, partial cds.
KJ904665 - Synthetic construct Homo sapiens clone ccsbBroadEn_14059 MORF4 gene, encodes complete protein.
KJ906062 - Synthetic construct Homo sapiens clone ccsbBroadEn_15732 MORF4L1 gene, encodes complete protein.
BC121092 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:150374 IMAGE:40119977), complete cds.
BC121093 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:150375 IMAGE:40119978), complete cds.
JD050743 - Sequence 31767 from Patent EP1572962.
JD295302 - Sequence 276326 from Patent EP1572962.
JD249088 - Sequence 230112 from Patent EP1572962.
JD498070 - Sequence 479094 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UBU8 (Reactome details) participates in the following event(s):

R-HSA-3321975 NuA4 complex acetylates histone H2A, HIST1H4
R-NUL-4551334 NuA4 complex actetylates H2A and H4
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: B4DKN6, D3DW88, FWP006, HSPC008, HSPC061, MO4L1_HUMAN, MRG15, NM_206839, NP_001252534, O95899, PP368, Q5QTS1, Q6NVX8, Q86YT7, Q9HBP6, Q9NSW5, Q9UBU8, uc002bel.3
UCSC ID: uc002bel.4
RefSeq Accession: NM_206839
Protein: Q9UBU8 (aka MO4L1_HUMAN)
CCDS: CCDS10307.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_206839.2
exon count: 13CDS single in 3' UTR: no RNA size: 2011
ORF size: 1089CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2372.00frame shift in genome: no % Coverage: 99.35
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.