Human Gene ZNF710 (uc002bov.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 710 (ZNF710), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:90,544,752-90,625,432 Size: 80,681 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr15:90,610,370-90,623,061 Size: 12,692 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:90,544,752-90,625,432)mRNA (may differ from genome)Protein (664 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 710;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.31 RPKM in Pancreas
Total median expression: 273.04 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.60123-0.525 Picture PostScript Text
3' UTR -988.592371-0.417 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q8N1W2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
  Ensembl  SGD
  Protein Sequence  Protein Sequence
  Alignment  Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  BC020301 - Homo sapiens zinc finger protein 710, mRNA (cDNA clone IMAGE:5108073).
AK094712 - Homo sapiens cDNA FLJ37393 fis, clone BRAMY2027073, moderately similar to Fugu rubripes zinc finger protein.
BC126476 - Homo sapiens zinc finger protein 710, mRNA (cDNA clone MGC:161754 IMAGE:8992192), complete cds.
BC130541 - Homo sapiens zinc finger protein 710, mRNA (cDNA clone MGC:163413 IMAGE:40146572), complete cds.
DQ594760 - Homo sapiens piRNA piR-60872, complete sequence.
AK160373 - Homo sapiens mRNA for FLJ00306 protein.
AL831826 - Homo sapiens mRNA; cDNA DKFZp547K1113 (from clone DKFZp547K1113).
LF207737 - JP 2014500723-A/15240: Polycomb-Associated Non-Coding RNAs.
DQ591157 - Homo sapiens piRNA piR-58269, complete sequence.
MA443314 - JP 2018138019-A/15240: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N1W2 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVS3, NM_198526, NP_940928, Q6ZMK9, Q8N1W2, Q8NDU0, ZN710_HUMAN
UCSC ID: uc002bov.2
RefSeq Accession: NM_198526
Protein: Q8N1W2 (aka ZN710_HUMAN)
CCDS: CCDS10358.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_198526.2
exon count: 5CDS single in 3' UTR: no RNA size: 4506
ORF size: 1995CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4178.00frame shift in genome: no % Coverage: 99.62
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.