Human Gene NR2F2 (uc002btp.3) Description and Page Index
  Description: Homo sapiens nuclear receptor subfamily 2, group F, member 2 (NR2F2), transcript variant 2, mRNA.
RefSeq Summary (NM_001145155): This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Transcript (Including UTRs)
   Position: hg19 chr15:96,869,157-96,883,492 Size: 14,336 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr15:96,869,539-96,880,851 Size: 11,313 Coding Exon Count: 3 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesGeneReviewsModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:96,869,157-96,883,492)mRNA (may differ from genome)Protein (281 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHuman Cortex Gene ExpressionLynxMGIOMIM
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NR2F2
CDC HuGE Published Literature: NR2F2
Positive Disease Associations: Body Height
Related Studies:
  1. Body Height
    , , . [PubMed 0]
  2. Body Height
    , , . [PubMed 0]
  3. Body Height
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: NR2F2
Diseases sorted by gene-association score: congenital heart defects, multiple types, 4* (1231), complete atrioventricular canal* (25), partial atrioventricular canal* (12), ring chromosome 15 (12), congenital diaphragmatic hernia (10), transposition of the great arteries (8), diaphragm disease (8), pulmonic stenosis (8), deafness, autosomal dominant 15 (6), endometriosis (3), maturity-onset diabetes of the young (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 117.33 RPKM in Ovary
Total median expression: 1118.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -114.40382-0.299 Picture PostScript Text
3' UTR -712.582641-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00104 - Ligand-binding domain of nuclear hormone receptor

SCOP Domains:
48508 - Nuclear receptor ligand-binding domain

ModBase Predicted Comparative 3D Structure on P24468-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC106083 - Homo sapiens nuclear receptor subfamily 2, group F, member 2, mRNA (cDNA clone MGC:117452 IMAGE:4453629), complete cds.
FM208183 - Homo sapiens mRNA for nuclear receptor subfamily 2, group F, member 2 (NR2F2 gene).
AK301595 - Homo sapiens cDNA FLJ50900 complete cds, highly similar to COUP transcription factor 2.
HQ692849 - Homo sapiens chicken ovalbumin upstream promoter-transcription factor II variant 2 (NR2F2) mRNA, complete cds.
BC042897 - Homo sapiens nuclear receptor subfamily 2, group F, member 2, mRNA (cDNA clone MGC:35309 IMAGE:5177487), complete cds.
M62760 - Homo sapiens chick ovalbumin upstream promoter transcription factor II (COUP-TFII) mRNA, partial cds.
M64497 - Human apolipoprotein AI regulatory protein (ARP-1) mRNA, complete cds.
BC014664 - Homo sapiens nuclear receptor subfamily 2, group F, member 2, mRNA (cDNA clone MGC:23125 IMAGE:4849984), complete cds.
AB590514 - Synthetic construct DNA, clone: pFN21AB7696, Homo sapiens NR2F2 gene for nuclear receptor subfamily 2, group F, member 2, without stop codon, in Flexi system.
AB307711 - Homo sapiens NR2F2 mRNA for ovalbumin upstream promoter transcription factor II, complete cds.
HQ692848 - Homo sapiens chicken ovalbumin upstream promoter-transcription factor II variant 1 (NR2F2) mRNA, complete cds.
AK316086 - Homo sapiens cDNA, FLJ78985 complete cds, highly similar to COUP transcription factor 2.
BC034585 - Homo sapiens, Similar to nuclear receptor subfamily 2, group F, member 2, clone IMAGE:4755247, mRNA.
AK298824 - Homo sapiens cDNA FLJ53083 complete cds, highly similar to COUP transcription factor 2.
HQ692850 - Homo sapiens chicken ovalbumin upstream promoter-transcription factor II variant 3 (NR2F2) mRNA, complete cds.
AK025842 - Homo sapiens cDNA: FLJ22189 fis, clone HRC01043.
BX538114 - Homo sapiens mRNA; cDNA DKFZp686C16163 (from clone DKFZp686C16163).
JD360089 - Sequence 341113 from Patent EP1572962.
BC033957 - Homo sapiens nuclear receptor subfamily 2, group F, member 2, mRNA (cDNA clone IMAGE:5287010).
JD562810 - Sequence 543834 from Patent EP1572962.
JD338881 - Sequence 319905 from Patent EP1572962.
JD531148 - Sequence 512172 from Patent EP1572962.
AF087993 - Homo sapiens full length insert cDNA clone YX37E06.

-  Other Names for This Gene
  Alternate Gene Symbols: ARP1, NM_001145155, NP_001138629, P24468-2, TFCOUP2
UCSC ID: uc002btp.3
RefSeq Accession: NM_001145155
Protein: P24468-2, splice isoform of P24468 CCDS: CCDS45358.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene NR2F2:
cdh-ov (Congenital Diaphragmatic Hernia Overview)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001145155.1
exon count: 3CDS single in 3' UTR: no RNA size: 3869
ORF size: 846CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1742.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.