Human Gene CTF1 (uc002dzw.3) Description and Page Index
  Description: Homo sapiens cardiotrophin 1 (CTF1), transcript variant 1, mRNA.
RefSeq Summary (NM_001330): The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Transcript (Including UTRs)
   Position: hg19 chr16:30,907,928-30,914,881 Size: 6,954 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr16:30,907,965-30,913,860 Size: 5,896 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:30,907,928-30,914,881)mRNA (may differ from genome)Protein (201 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CTF1_HUMAN
DESCRIPTION: RecName: Full=Cardiotrophin-1; Short=CT-1;
FUNCTION: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.
SIMILARITY: Belongs to the IL-6 superfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CTF1
CDC HuGE Published Literature: CTF1
Positive Disease Associations: Triglycerides
Related Studies:
  1. Triglycerides
    Tanya M Teslovich et al. Nature 2010, Biological, clinical and population relevance of 95 loci for blood lipids., Nature. [PubMed 20686565]

-  MalaCards Disease Associations
  MalaCards Gene Search: CTF1
Diseases sorted by gene-association score: neonatal stroke (12), hypertensive heart disease (9), dilated cardiomyopathy (5), motor neuron disease (3), heart disease (2), myocardial infarction (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.08 RPKM in Uterus
Total median expression: 281.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.1037-0.192 Picture PostScript Text
3' UTR -350.851021-0.344 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR010681 - PRF

SCOP Domains:
47266 - 4-helical cytokines

ModBase Predicted Comparative 3D Structure on Q16619
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005146 leukemia inhibitory factor receptor binding
GO:0005515 protein binding

Biological Process:
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0007517 muscle organ development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0048666 neuron development
GO:0048861 leukemia inhibitory factor signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC064416 - Homo sapiens cardiotrophin 1, mRNA (cDNA clone MGC:70822 IMAGE:5750481), complete cds.
U43030 - Homo sapiens cardiotrophin-1 (CTF1) mRNA, complete cds.
JD395528 - Sequence 376552 from Patent EP1572962.
BC049822 - Homo sapiens cardiotrophin 1, mRNA (cDNA clone IMAGE:5806399).
BC036787 - Homo sapiens cardiotrophin 1, mRNA (cDNA clone MGC:46223 IMAGE:5754188), complete cds.
JD333859 - Sequence 314883 from Patent EP1572962.
JD394458 - Sequence 375482 from Patent EP1572962.
JD161735 - Sequence 142759 from Patent EP1572962.
JD293790 - Sequence 274814 from Patent EP1572962.
JD402894 - Sequence 383918 from Patent EP1572962.
JD498766 - Sequence 479790 from Patent EP1572962.
JD219765 - Sequence 200789 from Patent EP1572962.
JD228844 - Sequence 209868 from Patent EP1572962.
JD255764 - Sequence 236788 from Patent EP1572962.
JD212212 - Sequence 193236 from Patent EP1572962.
JD131789 - Sequence 112813 from Patent EP1572962.
JD072897 - Sequence 53921 from Patent EP1572962.
JD293491 - Sequence 274515 from Patent EP1572962.
JD070285 - Sequence 51309 from Patent EP1572962.
JD397973 - Sequence 378997 from Patent EP1572962.
JD416489 - Sequence 397513 from Patent EP1572962.
JD346759 - Sequence 327783 from Patent EP1572962.
JD272986 - Sequence 254010 from Patent EP1572962.
JD092148 - Sequence 73172 from Patent EP1572962.
JD535811 - Sequence 516835 from Patent EP1572962.
JD432094 - Sequence 413118 from Patent EP1572962.
JD080088 - Sequence 61112 from Patent EP1572962.
JD320540 - Sequence 301564 from Patent EP1572962.
JD525570 - Sequence 506594 from Patent EP1572962.
JD391912 - Sequence 372936 from Patent EP1572962.
JD131938 - Sequence 112962 from Patent EP1572962.
JD555202 - Sequence 536226 from Patent EP1572962.
JD422989 - Sequence 404013 from Patent EP1572962.
JD053020 - Sequence 34044 from Patent EP1572962.
JD240894 - Sequence 221918 from Patent EP1572962.
JD404939 - Sequence 385963 from Patent EP1572962.
JD323470 - Sequence 304494 from Patent EP1572962.
JD341569 - Sequence 322593 from Patent EP1572962.
JD297970 - Sequence 278994 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04630 - Jak-STAT signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)

Reactome (by CSHL, EBI, and GO)

Protein Q16619 (Reactome details) participates in the following event(s):

R-HSA-5696482 CTF1 binds LIFR:JAKs
R-HSA-6783524 OSM,LIF,CTF1 receptor complex binds gp130
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-6783589 Interleukin-6 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A8MVX4, CTF1_HUMAN, NM_001330, NP_001321, Q16619, Q5U5Y7
UCSC ID: uc002dzw.3
RefSeq Accession: NM_001330
Protein: Q16619 (aka CTF1_HUMAN)
CCDS: CCDS10694.1, CCDS45464.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001330.3
exon count: 3CDS single in 3' UTR: no RNA size: 1681
ORF size: 606CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 1412.00frame shift in genome: no % Coverage: 98.99
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.