Human Gene CTF1 (uc002dzw.3) Description and Page Index
Description: Homo sapiens cardiotrophin 1 (CTF1), transcript variant 1, mRNA. RefSeq Summary (NM_001330): The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. Transcript (Including UTRs) Position: hg19 chr16:30,907,928-30,914,881 Size: 6,954 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr16:30,907,965-30,913,860 Size: 5,896 Coding Exon Count: 3
ID:CTF1_HUMAN DESCRIPTION: RecName: Full=Cardiotrophin-1; Short=CT-1; FUNCTION: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes. SIMILARITY: Belongs to the IL-6 superfamily.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CTF1 CDC HuGE Published Literature: CTF1 Positive Disease Associations: Triglycerides Related Studies:
Triglycerides Tanya M Teslovich et al. Nature 2010, Biological, clinical and population relevance of 95 loci for blood lipids., Nature.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16619
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.