Human Gene CDH1 (uc002ewg.1) Description and Page Index
  Description: Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA.
RefSeq Summary (NM_004360): This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015].
Transcript (Including UTRs)
   Position: hg19 chr16:68,771,195-68,869,444 Size: 98,250 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr16:68,771,319-68,867,402 Size: 96,084 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:68,771,195-68,869,444)mRNA (may differ from genome)Protein (882 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CADH1_HUMAN
DESCRIPTION: RecName: Full=Cadherin-1; AltName: Full=CAM 120/80; AltName: Full=Epithelial cadherin; Short=E-cadherin; AltName: Full=Uvomorulin; AltName: CD_antigen=CD324; Contains: RecName: Full=E-Cad/CTF1; Contains: RecName: Full=E-Cad/CTF2; Contains: RecName: Full=E-Cad/CTF3; Flags: Precursor;
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
SUBUNIT: Homodimer; disulfide-linked. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha- catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F- actin by other proteins such as LIMA1. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (By similarity). Interacts with TBC1D2. Interacts with LIMA1. Interacts with CAV1. Interacts with the TRPV4 and CTNNB1 complex (By similarity). Interacts with PIP5K1C. Interacts with RAB8B (By similarity). Interacts with DDR1; this stabilizes CDH1 at the cell surface and inhibits its internalization.
INTERACTION: P30260:CDC27; NbExp=2; IntAct=EBI-727477, EBI-994813; P35222:CTNNB1; NbExp=6; IntAct=EBI-727477, EBI-491549; P11362:FGFR1; NbExp=2; IntAct=EBI-727477, EBI-1028277; P62136:PPP1CA; NbExp=2; IntAct=EBI-727477, EBI-357253; Q15139:PRKD1; NbExp=7; IntAct=EBI-727477, EBI-1181072; P12931:SRC; NbExp=2; IntAct=EBI-727477, EBI-621482; Q68CZ2:TNS3; NbExp=2; IntAct=EBI-727477, EBI-1220488;
SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
TISSUE SPECIFICITY: Non-neural epithelial tissues.
INDUCTION: Expression is repressed by MACROD1.
PTM: During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions.
PTM: N-glycosylation at Asn-637 is essential for expression, folding and trafficking.
PTM: Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1.
DISEASE: Defects in CDH1 are the cause of hereditary diffuse gastric cancer (HDGC) [MIM:137215]. An autosomal dominant cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. Note=Heterozygous germline mutations CDH1 are responsible for familial cases of diffuse gastric cancer. Somatic mutations in the has also been found in patients with sporadic diffuse gastric cancer and lobular breast cancer.
DISEASE: Defects in CDH1 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].
DISEASE: Defects in CDH1 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
SIMILARITY: Contains 5 cadherin domains.
SEQUENCE CAUTION: Sequence=AAA61259.1; Type=Frameshift; Positions=16, 22, 25, 28, 31, 34, 52, 67, 73, 76, 94, 102, 633, 636;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDH1ID166ch16q22.html";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CDH1";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdh1/";
WEB RESOURCE: Name=Wikipedia; Note=E-cadherin entry; URL="http://en.wikipedia.org/wiki/E-cadherin";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDH1
CDC HuGE Published Literature: CDH1
Positive Disease Associations: bladder cancer , colorectal cancer , Colorectal Neoplasms , Crohn Disease| , diffuse gastric cancer , gastric carcinoma risk , prostate cancer , stomach cancer , transitional cell carcinoma of the bladder. , ulcerative colitis , urinary calculus , urothelial cancer
Related Studies:
  1. bladder cancer
    Zhang, X. et al. 2003, Association between a C/A single nucleotide polymorphism of the E-cadherin gene promoter and transitional cell carcinoma of the bladder., The Journal of urology. 2003 Oct;170(4 Pt 1):1379-82. [PubMed 14501773]
    The -160 C/A single nucleotide polymorphism of the E-cadherin gene promoter is associated with TCCB. This single nucleotide polymorphism may serve as a prognostic marker of TCCB.
  2. colorectal cancer
    Shin, Y. et al. 2004, A functional polymorphism (-347 G-->GA) in the E-cadherin gene is associated with colorectal cancer., Carcinogenesis. 2004 Nov;25(11):2173-6. [PubMed 15231691]
    Taken together, our results suggest that the E-cadherin -347 G-->GA polymorphism may be associated with colorectal cancer.
  3. colorectal cancer
    Wheeler JM et al. 2001, Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer., Gut. 2001 Mar;48(3):367-71. [PubMed 11171827]
    We have demonstrated hypermethylation of the promoter region in CDH1 in 46% of colorectal cancers studied. There was no difference between the UCACRC and SCRC groups. Just as there are specific differences in the genetic changes between UCACRC and SCRC, there is also likely to be a large degree of overlap among the genetic pathways of these cancers.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: CDH1
Diseases sorted by gene-association score: gastric cancer risk after h. pylori infection* (1650), breast cancer* (476), endometrial cancer* (252), ovarian cancer, somatic* (190), prostate cancer* (177), diffuse gastric cancer (41), prostate cancer susceptibility* (41), gastric adenocarcinoma (32), inflammatory breast carcinoma (31), lobular neoplasia (26), goblet cell carcinoid (23), gallbladder cancer (23), bladder urothelial carcinoma (21), biphasic synovial sarcoma (21), epstein-barr virus-associated gastric carcinoma (18), breast ductal carcinoma (18), pseudo-meigs syndrome (18), gastric diffuse adenocarcinoma (16), tongue cancer (16), adenoid squamous cell carcinoma (15), ovarian stromal hyperthecosis (15), renal fibrosis (14), sarcomatoid transitional cell carcinoma (14), colorectal cancer (14), thyroid cancer (14), bladder signet ring cell adenocarcinoma (14), cleft lip/palate* (13), stomach cancer (13), microinvasive gastric cancer (12), esophagus squamous cell carcinoma (12), bile duct carcinoma (12), oral squamous cell carcinoma (12), transitional cell carcinoma (12), adenocarcinoma (12), bladder cancer, somatic (11), urinary bladder cancer (11), signet ring cell adenocarcinoma (11), tongue squamous cell carcinoma (11), familial adenomatous polyposis (10), pemphigus vulgaris (10), nasopharyngeal carcinoma (10), colon adenocarcinoma (10), linitis plastica (9), h. pylori infection (9), hailey-hailey disease (9), gastric cardia carcinoma (9), gastric cancer, somatic (9), lung giant cell carcinoma (9), pancreatic ductal adenocarcinoma (9), sarcoma, synovial (8), papillary adenocarcinoma (8), salivary gland adenoid cystic carcinoma (8), cholangiocarcinoma, susceptibility to (8), breast cystic hypersecretory carcinoma (8), parasagittal meningioma (8), darier disease (8), choroid plexus papilloma (8), intrahepatic cholangiocarcinoma (8), oral cancer (8), tubular adenocarcinoma (8), interstitial cystitis (7), cervical squamous cell carcinoma (7), spindle cell carcinoma (7), crohn's colitis (7), oral submucous fibrosis (7), cholecystitis (7), ductal carcinoma in situ (7), cerebral convexity meningioma (7), squamous cell carcinoma of the oral tongue (7), gastric signet ring cell adenocarcinoma (7), colorectal adenocarcinoma (7), diversion colitis (7), hereditary spastic paraplegia 3a (7), hypotrichosis, congenital, with juvenile macular dystrophy (7), squamous cell carcinoma (7), mesothelioma, somatic (6), lung cancer susceptibility 3 (6), pre-malignant neoplasm (6), lymphoepithelioma-like carcinoma (6), extrahepatic bile duct adenocarcinoma (6), squamous cell carcinoma, head and neck (6), infiltrative basal cell carcinoma (6), vulvar intraepithelial neoplasia (6), adenomatous polyposis coli (6), pancreatic cancer (6), listeriosis (6), ovary epithelial cancer (6), malignant ovarian surface epithelial-stromal neoplasm (6), adhesions of uterus (6), familial colorectal cancer (6), cell type cancer (6), chordoma (5), morpheaform basal cell carcinoma (5), gastrointestinal system cancer (5), ureteral disease (5), pharynx cancer (5), hypopharynx cancer (5), reproductive organ cancer (5), lung cancer (5), in situ carcinoma (5), parotid gland cancer (5), breast squamous cell carcinoma (4), malignant epithelial mesothelioma (4), lipid-rich carcinoma (4), chondroid chordoma (4), pancreas adenocarcinoma (4), microcystic meningioma (4), functional diarrhea (4), breast metaplastic carcinoma (4), hepatocellular carcinoma (4), intestinal benign neoplasm (4), esophageal cancer (3), melanoma (3), renal cell carcinoma (2), hepatitis c virus (2), adamantinoma of long bones (2), female reproductive organ cancer (2), male reproductive organ cancer (2), urinary tract obstruction (1), tooth agenesis (1), bile duct adenocarcinoma (1), eye disease (1), gastrointestinal system benign neoplasm (1), endocrine gland cancer (1), pulmonary fibrosis, idiopathic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.97 RPKM in Esophagus - Mucosa
Total median expression: 590.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.80124-0.377 Picture PostScript Text
3' UTR -622.772042-0.305 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002126 - Cadherin
IPR015919 - Cadherin-like
IPR020894 - Cadherin_CS
IPR000233 - Cadherin_cytoplasmic-dom
IPR014868 - Cadherin_pro_dom

Pfam Domains:
PF00028 - Cadherin domain
PF01049 - Cadherin cytoplasmic region
PF08758 - Cadherin prodomain like

SCOP Domains:
49313 - Cadherin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1O6S
- X-ray MuPIT

2O72
- X-ray MuPIT

2OMT
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2OMU - X-ray MuPIT 2OMV - X-ray MuPIT 2OMX - X-ray MuPIT
2OMY - X-ray MuPIT 2OMZ - X-ray MuPIT 3FF7 - X-ray MuPIT
3FF8 - X-ray MuPIT 3L6X - X-ray MuPIT 3L6Y - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P12830
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0030506 ankyrin binding
GO:0032794 GTPase activating protein binding
GO:0042802 identical protein binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding

Biological Process:
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007416 synapse assembly
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0021983 pituitary gland development
GO:0022408 negative regulation of cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0031175 neuron projection development
GO:0034332 adherens junction organization
GO:0035635 entry of bacterium into host cell
GO:0042307 positive regulation of protein import into nucleus
GO:0042493 response to drug
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071285 cellular response to lithium ion
GO:0071681 cellular response to indole-3-methanol
GO:0072659 protein localization to plasma membrane
GO:0098609 cell-cell adhesion

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0009898 cytoplasmic side of plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0016600 flotillin complex
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0043296 apical junction complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0030864 cortical actin cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK312551 - Homo sapiens cDNA, FLJ92924, Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1),mRNA.
AK297913 - Homo sapiens cDNA FLJ60313 complete cds, highly similar to Epithelial-cadherin precursor.
EU709494 - Homo sapiens truncated E-cadherin (CDH1) mRNA, complete cds.
GQ891411 - Homo sapiens clone HEL-S-131 epididymis secretory sperm binding protein mRNA, complete cds.
LF384443 - JP 2014500723-A/191946: Polycomb-Associated Non-Coding RNAs.
L08599 - Human uvomorulin (E-cadherin) (UVO) mRNA, complete cds.
BC141838 - Homo sapiens cadherin 1, type 1, E-cadherin (epithelial), mRNA (cDNA clone MGC:165111 IMAGE:40148986), complete cds.
BC146662 - Homo sapiens cadherin 1, type 1, E-cadherin (epithelial), mRNA (cDNA clone MGC:164884 IMAGE:40148047), complete cds.
BC144283 - Homo sapiens cDNA clone IMAGE:9052803, containing frame-shift errors.
AK290012 - Homo sapiens cDNA FLJ78203 complete cds, highly similar to Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA.
Z13009 - H.sapiens mRNA for E-cadherin.
BC015576 - Homo sapiens mRNA similar to cadherin 1, type 1, E-cadherin (epithelial) (cDNA clone IMAGE:3959042).
AB025105 - Homo sapiens mRNA for E-cadherin, complete cds.
AB025106 - Homo sapiens mRNA for E-cadherin, complete cds.
Z18923 - H.sapiens mRNA for E-cadherin.
AK309703 - Homo sapiens cDNA, FLJ99744.
AK311198 - Homo sapiens cDNA, FLJ18240.
MA620020 - JP 2018138019-A/191946: Polycomb-Associated Non-Coding RNAs.
JD287654 - Sequence 268678 from Patent EP1572962.
JD104639 - Sequence 85663 from Patent EP1572962.
LF374261 - JP 2014500723-A/181764: Polycomb-Associated Non-Coding RNAs.
LF374263 - JP 2014500723-A/181766: Polycomb-Associated Non-Coding RNAs.
X12790 - Human mRNA for uvomorulin (put. CAM 120/80).
LF374264 - JP 2014500723-A/181767: Polycomb-Associated Non-Coding RNAs.
LF374265 - JP 2014500723-A/181768: Polycomb-Associated Non-Coding RNAs.
LF374267 - JP 2014500723-A/181770: Polycomb-Associated Non-Coding RNAs.
X52279 - H.sapiens mRNA for ARC-1/uvomorulin.
LF374269 - JP 2014500723-A/181772: Polycomb-Associated Non-Coding RNAs.
LF374270 - JP 2014500723-A/181773: Polycomb-Associated Non-Coding RNAs.
LF374271 - JP 2014500723-A/181774: Polycomb-Associated Non-Coding RNAs.
LF374273 - JP 2014500723-A/181776: Polycomb-Associated Non-Coding RNAs.
LF374275 - JP 2014500723-A/181778: Polycomb-Associated Non-Coding RNAs.
LF374278 - JP 2014500723-A/181781: Polycomb-Associated Non-Coding RNAs.
LF374282 - JP 2014500723-A/181785: Polycomb-Associated Non-Coding RNAs.
LF374284 - JP 2014500723-A/181787: Polycomb-Associated Non-Coding RNAs.
LF374286 - JP 2014500723-A/181789: Polycomb-Associated Non-Coding RNAs.
LF374287 - JP 2014500723-A/181790: Polycomb-Associated Non-Coding RNAs.
JD058481 - Sequence 39505 from Patent EP1572962.
JD466853 - Sequence 447877 from Patent EP1572962.
JD330340 - Sequence 311364 from Patent EP1572962.
JD241004 - Sequence 222028 from Patent EP1572962.
LF374289 - JP 2014500723-A/181792: Polycomb-Associated Non-Coding RNAs.
LF208297 - JP 2014500723-A/15800: Polycomb-Associated Non-Coding RNAs.
JD554654 - Sequence 535678 from Patent EP1572962.
JD112473 - Sequence 93497 from Patent EP1572962.
JD320565 - Sequence 301589 from Patent EP1572962.
JD320853 - Sequence 301877 from Patent EP1572962.
LF374290 - JP 2014500723-A/181793: Polycomb-Associated Non-Coding RNAs.
JD566358 - Sequence 547382 from Patent EP1572962.
JD358287 - Sequence 339311 from Patent EP1572962.
JD289756 - Sequence 270780 from Patent EP1572962.
JD351089 - Sequence 332113 from Patent EP1572962.
JD513039 - Sequence 494063 from Patent EP1572962.
JD317670 - Sequence 298694 from Patent EP1572962.
JD371347 - Sequence 352371 from Patent EP1572962.
JD337731 - Sequence 318755 from Patent EP1572962.
JD367707 - Sequence 348731 from Patent EP1572962.
JD535557 - Sequence 516581 from Patent EP1572962.
JD252516 - Sequence 233540 from Patent EP1572962.
JD197676 - Sequence 178700 from Patent EP1572962.
JD197447 - Sequence 178471 from Patent EP1572962.
JD071874 - Sequence 52898 from Patent EP1572962.
JD350553 - Sequence 331577 from Patent EP1572962.
JD486130 - Sequence 467154 from Patent EP1572962.
JD488125 - Sequence 469149 from Patent EP1572962.
JD560764 - Sequence 541788 from Patent EP1572962.
JD476887 - Sequence 457911 from Patent EP1572962.
JD397387 - Sequence 378411 from Patent EP1572962.
JD415497 - Sequence 396521 from Patent EP1572962.
JD415498 - Sequence 396522 from Patent EP1572962.
JD180408 - Sequence 161432 from Patent EP1572962.
JD346071 - Sequence 327095 from Patent EP1572962.
JD504824 - Sequence 485848 from Patent EP1572962.
JD438601 - Sequence 419625 from Patent EP1572962.
JD532122 - Sequence 513146 from Patent EP1572962.
JD464193 - Sequence 445217 from Patent EP1572962.
JD149859 - Sequence 130883 from Patent EP1572962.
JD251500 - Sequence 232524 from Patent EP1572962.
JD386123 - Sequence 367147 from Patent EP1572962.
JD351637 - Sequence 332661 from Patent EP1572962.
JD522975 - Sequence 503999 from Patent EP1572962.
JD457290 - Sequence 438314 from Patent EP1572962.
JD457291 - Sequence 438315 from Patent EP1572962.
JD388668 - Sequence 369692 from Patent EP1572962.
JD277462 - Sequence 258486 from Patent EP1572962.
JD248836 - Sequence 229860 from Patent EP1572962.
JD337764 - Sequence 318788 from Patent EP1572962.
JD160203 - Sequence 141227 from Patent EP1572962.
JD490864 - Sequence 471888 from Patent EP1572962.
JD245803 - Sequence 226827 from Patent EP1572962.
JD544149 - Sequence 525173 from Patent EP1572962.
JD310956 - Sequence 291980 from Patent EP1572962.
JD255536 - Sequence 236560 from Patent EP1572962.
JD124312 - Sequence 105336 from Patent EP1572962.
JD312232 - Sequence 293256 from Patent EP1572962.
JD283009 - Sequence 264033 from Patent EP1572962.
JD424306 - Sequence 405330 from Patent EP1572962.
JD046813 - Sequence 27837 from Patent EP1572962.
LF374291 - JP 2014500723-A/181794: Polycomb-Associated Non-Coding RNAs.
BC013851 - Homo sapiens cadherin 1, type 1, E-cadherin (epithelial), mRNA (cDNA clone IMAGE:3864475).
JD146835 - Sequence 127859 from Patent EP1572962.
LF374292 - JP 2014500723-A/181795: Polycomb-Associated Non-Coding RNAs.
JD146953 - Sequence 127977 from Patent EP1572962.
JD551766 - Sequence 532790 from Patent EP1572962.
JD305888 - Sequence 286912 from Patent EP1572962.
LF374294 - JP 2014500723-A/181797: Polycomb-Associated Non-Coding RNAs.
JD121137 - Sequence 102161 from Patent EP1572962.
JD433326 - Sequence 414350 from Patent EP1572962.
JD363575 - Sequence 344599 from Patent EP1572962.
LF374295 - JP 2014500723-A/181798: Polycomb-Associated Non-Coding RNAs.
JD073189 - Sequence 54213 from Patent EP1572962.
LF374296 - JP 2014500723-A/181799: Polycomb-Associated Non-Coding RNAs.
JD556984 - Sequence 538008 from Patent EP1572962.
MA609838 - JP 2018138019-A/181764: Polycomb-Associated Non-Coding RNAs.
MA609840 - JP 2018138019-A/181766: Polycomb-Associated Non-Coding RNAs.
MA609841 - JP 2018138019-A/181767: Polycomb-Associated Non-Coding RNAs.
MA609842 - JP 2018138019-A/181768: Polycomb-Associated Non-Coding RNAs.
MA609844 - JP 2018138019-A/181770: Polycomb-Associated Non-Coding RNAs.
MA609846 - JP 2018138019-A/181772: Polycomb-Associated Non-Coding RNAs.
MA609847 - JP 2018138019-A/181773: Polycomb-Associated Non-Coding RNAs.
MA609848 - JP 2018138019-A/181774: Polycomb-Associated Non-Coding RNAs.
MA609850 - JP 2018138019-A/181776: Polycomb-Associated Non-Coding RNAs.
MA609852 - JP 2018138019-A/181778: Polycomb-Associated Non-Coding RNAs.
MA609855 - JP 2018138019-A/181781: Polycomb-Associated Non-Coding RNAs.
MA609859 - JP 2018138019-A/181785: Polycomb-Associated Non-Coding RNAs.
MA609861 - JP 2018138019-A/181787: Polycomb-Associated Non-Coding RNAs.
MA609863 - JP 2018138019-A/181789: Polycomb-Associated Non-Coding RNAs.
MA609864 - JP 2018138019-A/181790: Polycomb-Associated Non-Coding RNAs.
MA609866 - JP 2018138019-A/181792: Polycomb-Associated Non-Coding RNAs.
MA443874 - JP 2018138019-A/15800: Polycomb-Associated Non-Coding RNAs.
MA609867 - JP 2018138019-A/181793: Polycomb-Associated Non-Coding RNAs.
MA609868 - JP 2018138019-A/181794: Polycomb-Associated Non-Coding RNAs.
MA609869 - JP 2018138019-A/181795: Polycomb-Associated Non-Coding RNAs.
MA609871 - JP 2018138019-A/181797: Polycomb-Associated Non-Coding RNAs.
MA609872 - JP 2018138019-A/181798: Polycomb-Associated Non-Coding RNAs.
MA609873 - JP 2018138019-A/181799: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04514 - Cell adhesion molecules (CAMs)
hsa04520 - Adherens junction
hsa05100 - Bacterial invasion of epithelial cells
hsa05130 - Pathogenic Escherichia coli infection
hsa05200 - Pathways in cancer
hsa05213 - Endometrial cancer
hsa05216 - Thyroid cancer
hsa05218 - Melanoma
hsa05219 - Bladder cancer

Reactome (by CSHL, EBI, and GO)

Protein P12830 (Reactome details) participates in the following event(s):

R-HSA-199079 Epithelial cadherin binds to KLRG1
R-HSA-202939 Caspase-mediated cleavage of E-Cadherin
R-HSA-265422 Interaction of integrin alphaEbeta7 with Cadherin-1
R-HSA-1454843 E-cadherin degradation by MMP3, MMP7 and plasmin.
R-HSA-2534206 E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
R-NUL-2534209 E-cadherin strand dimer degradation by PS1
R-HSA-2534260 E-cadherin degradation by caspase-3 and calpain-1
R-HSA-3827958 E-cadherin degradation by MMP9, KLK7
R-HSA-4224014 E-cadherin degradation by ADAM10, ADAM15
R-HSA-419001 Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin
R-HSA-419002 Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin
R-HSA-5672304 IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
R-HSA-8876497 InlA binds CDH1
R-HSA-8876993 CBLL1 binds SRC-phosphorylated CDH1 complex
R-HSA-8877003 CBLL1 ubiqutinates the InlA-bound CDH1 complex
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins
R-HSA-216083 Integrin cell surface interactions
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-418990 Adherens junctions interactions
R-HSA-1280218 Adaptive Immune System
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-1474244 Extracellular matrix organization
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-421270 Cell-cell junction organization
R-HSA-168256 Immune System
R-HSA-75153 Apoptotic execution phase
R-HSA-195258 RHO GTPase Effectors
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-446728 Cell junction organization
R-HSA-109581 Apoptosis
R-HSA-194315 Signaling by Rho GTPases
R-HSA-5663205 Infectious disease
R-HSA-1500931 Cell-Cell communication
R-HSA-5357801 Programmed Cell Death
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1U7, CADH1_HUMAN, CDHE, NM_004360, NP_004351, P12830, Q13799, Q14216, Q15855, Q16194, Q4PJ14, UVO
UCSC ID: uc002ewg.1
RefSeq Accession: NM_004360
Protein: P12830 (aka CADH1_HUMAN or CAD1_HUMAN)
CCDS: CCDS10869.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene CDH1:
hgc (Hereditary Diffuse Gastric Cancer)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004360.3
exon count: 16CDS single in 3' UTR: no RNA size: 4815
ORF size: 2649CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5273.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.