Human Gene BCAR1 (uc002fdx.3) Description and Page Index
  Description: Homo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 2, mRNA.
RefSeq Summary (NM_001170715): The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017].
Transcript (Including UTRs)
   Position: hg19 chr16:75,262,928-75,301,951 Size: 39,024 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr16:75,263,409-75,301,878 Size: 38,470 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:75,262,928-75,301,951)mRNA (may differ from genome)Protein (888 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
Stanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Breast cancer anti-estrogen resistance protein 1;
SIMILARITY: Contains 1 SH3 domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): BCAR1
CDC HuGE Published Literature: BCAR1
Positive Disease Associations: Pancreatic Neoplasms
Related Studies:
  1. Pancreatic Neoplasms
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: BCAR1
Diseases sorted by gene-association score: estrogen resistance (28), differentiating neuroblastoma (15), breast cancer (15), nephronophthisis 1, juvenile (8), cerebral hypoxia (8), cystic kidney disease (6), nephronophthisis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.24 RPKM in Brain - Cerebellum
Total median expression: 569.93 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.2073-0.441 Picture PostScript Text
3' UTR -215.70481-0.448 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021901 - CAS_DUF3513
IPR014928 - Serine_rich
IPR001452 - SH3_domain
IPR013315 - Spectrin_alpha_SH3

Pfam Domains:
PF00018 - SH3 domain
PF07653 - Variant SH3 domain
PF08824 - Serine rich protein interaction domain
PF12026 - Domain of unknown function (DUF3513)
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain

ModBase Predicted Comparative 3D Structure on E9PCV2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGD FlyBase  
 Protein Sequence Protein Sequence  
 Alignment Alignment  

-  Descriptions from all associated GenBank mRNAs
  AK124526 - Homo sapiens cDNA FLJ42535 fis, clone BRACE3003595, highly similar to Breast cancer anti-estrogen resistance protein 1.
AK026121 - Homo sapiens cDNA: FLJ22468 fis, clone HRC10347, highly similar to AB040024 Homo sapiens hp130Cas mRNA for adaptor protein p130Cas.
BC014402 - Homo sapiens, Similar to breast cancer anti-estrogen resistance 1, clone IMAGE:3506960, mRNA, partial cds.
BC062556 - Homo sapiens breast cancer anti-estrogen resistance 1, mRNA (cDNA clone MGC:71216 IMAGE:6427808), complete cds.
AJ242987 - Homo sapiens mRNA for breast cancer anti-estrogen resistance 1 protein (BCAR1 gene).
AK125719 - Homo sapiens cDNA FLJ43731 fis, clone TESTI1000391, highly similar to Breast cancer anti-estrogen resistance protein 1.
AK124844 - Homo sapiens cDNA FLJ42854 fis, clone BRHIP2008607, highly similar to Breast cancer anti-estrogen resistance protein 1.
AK074958 - Homo sapiens cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA.
AB040024 - Homo sapiens hp130Cas mRNA for adaptor protein p130Cas, complete cds.
AK124815 - Homo sapiens cDNA FLJ42825 fis, clone BRCAN2016619, highly similar to Breast cancer anti-estrogen resistance protein 1.
AK302617 - Homo sapiens cDNA FLJ55908 complete cds, highly similar to Breast cancer anti-estrogen resistance protein 1.
AF218451 - Homo sapiens Crk-associated substrate p130Cas mRNA, complete cds.
AK027608 - Homo sapiens cDNA FLJ14702 fis, clone NT2RP3000299, moderately similar to Rattus norvegicus mRNA for Crk-associated substrate, p130.
JD081968 - Sequence 62992 from Patent EP1572962.
JD109823 - Sequence 90847 from Patent EP1572962.
AK293808 - Homo sapiens cDNA FLJ56057 complete cds, highly similar to Breast cancer anti-estrogen resistance protein 1.
JD194546 - Sequence 175570 from Patent EP1572962.
JD070892 - Sequence 51916 from Patent EP1572962.
JD103369 - Sequence 84393 from Patent EP1572962.
JD382318 - Sequence 363342 from Patent EP1572962.
JD486997 - Sequence 468021 from Patent EP1572962.
JD100808 - Sequence 81832 from Patent EP1572962.
JD373052 - Sequence 354076 from Patent EP1572962.
JD459055 - Sequence 440079 from Patent EP1572962.
JD338321 - Sequence 319345 from Patent EP1572962.
JD342573 - Sequence 323597 from Patent EP1572962.
JD080004 - Sequence 61028 from Patent EP1572962.
JD269388 - Sequence 250412 from Patent EP1572962.
JD464515 - Sequence 445539 from Patent EP1572962.
AK294513 - Homo sapiens cDNA FLJ55930 complete cds, highly similar to Breast cancer anti-estrogen resistance protein 1.
AK295809 - Homo sapiens cDNA FLJ55515 complete cds, highly similar to Breast cancer anti-estrogen resistanceprotein 1.
JD118413 - Sequence 99437 from Patent EP1572962.
JD220666 - Sequence 201690 from Patent EP1572962.
JD135246 - Sequence 116270 from Patent EP1572962.
AY545071 - Homo sapiens breast cancer anti-estrogen resistance 1 (BCAR1) mRNA, complete cds, alternatively spliced.
EU831404 - Synthetic construct Homo sapiens clone HAIB:100066433; DKFZo008A0217 breast cancer anti-estrogen resistance 1 protein (BCAR1) gene, encodes complete protein.
AK314722 - Homo sapiens cDNA, FLJ95582, highly similar to Homo sapiens breast cancer anti-estrogen resistance 1 (BCAR1),mRNA.
EU831496 - Synthetic construct Homo sapiens clone HAIB:100066525; DKFZo004A0218 breast cancer anti-estrogen resistance 1 protein (BCAR1) gene, encodes complete protein.
AB587546 - Synthetic construct DNA, clone: pF1KE1059, Homo sapiens BCAR1 gene for breast cancer anti-estrogen resistance 1, without stop codon, in Flexi system.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04062 - Chemokine signaling pathway
hsa04510 - Focal adhesion
hsa04670 - Leukocyte transendothelial migration
hsa04810 - Regulation of actin cytoskeleton
hsa05100 - Bacterial invasion of epithelial cells

BioCarta from NCI Cancer Genome Anatomy Project
h_integrinPathway - Integrin Signaling Pathway
h_cxcr4Pathway - CXCR4 Signaling Pathway
h_cell2cellPathway - Cell to Cell Adhesion Signaling
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis

-  Other Names for This Gene
  Alternate Gene Symbols: E9PCV2, E9PCV2_HUMAN, NM_001170715, NP_001164186
UCSC ID: uc002fdx.3
RefSeq Accession: NM_001170715
Protein: E9PCV2 CCDS: CCDS10915.1, CCDS54037.1, CCDS54038.1, CCDS54041.1, CCDS54042.1, CCDS54043.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001170715.1
exon count: 7CDS single in 3' UTR: no RNA size: 3238
ORF size: 2667CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4436.00frame shift in genome: no % Coverage: 99.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.