Human Gene STAT3 (uc002hzk.1) Description and Page Index
  Description: Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA.
RefSeq Summary (NM_213662): The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015].
Transcript (Including UTRs)
   Position: hg19 chr17:40,465,343-40,540,513 Size: 75,171 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr17:40,468,845-40,500,534 Size: 31,690 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:40,465,343-40,540,513)mRNA (may differ from genome)Protein (722 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
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UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: STAT3_HUMAN
DESCRIPTION: RecName: Full=Signal transducer and activator of transcription 3; AltName: Full=Acute-phase response factor;
FUNCTION: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA.
SUBUNIT: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the 'Lys-129' acetylated form of BIRC5/survivin. Interacts with FER.
INTERACTION: O14874:BCKDK; NbExp=2; IntAct=EBI-518675, EBI-1046765; Q96G01:BICD1; NbExp=2; IntAct=EBI-518675, EBI-1104509; P07384:CAPN1; NbExp=2; IntAct=EBI-518675, EBI-1542113; P31146:CORO1A; NbExp=2; IntAct=EBI-518675, EBI-1046676; Q9UER7:DAXX; NbExp=4; IntAct=EBI-518675, EBI-77321; O95661:DIRAS3; NbExp=3; IntAct=EBI-518675, EBI-6139214; Q13011:ECH1; NbExp=2; IntAct=EBI-518675, EBI-711968; Q9BVP2:GNL3; NbExp=2; IntAct=EBI-518675, EBI-641642; Q07666:KHDRBS1; NbExp=2; IntAct=EBI-518675, EBI-1364; O43318:MAP3K7; NbExp=4; IntAct=EBI-518675, EBI-358684; P45984:MAPK9; NbExp=2; IntAct=EBI-518675, EBI-713568; P45984-1:MAPK9; NbExp=3; IntAct=EBI-518675, EBI-713586; Q8TE76:MORC4; NbExp=2; IntAct=EBI-518675, EBI-3940432; Q92665:MRPS31; NbExp=2; IntAct=EBI-518675, EBI-720602; P22736:NR4A1; NbExp=3; IntAct=EBI-518675, EBI-721550; Q9ULD0:OGDHL; NbExp=2; IntAct=EBI-518675, EBI-3940481; P06401:PGR; NbExp=3; IntAct=EBI-518675, EBI-78539; Q04206:RELA; NbExp=4; IntAct=EBI-518675, EBI-73886; P46781:RPS9; NbExp=2; IntAct=EBI-518675, EBI-351206; O00570:SOX1; NbExp=2; IntAct=EBI-518675, EBI-2935583; P30626:SRI; NbExp=2; IntAct=EBI-518675, EBI-750459; Q06520:SULT2A1; NbExp=2; IntAct=EBI-518675, EBI-3921363;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
PTM: Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA- binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphoryation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity.
DISEASE: Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
SIMILARITY: Belongs to the transcription factor STAT family.
SIMILARITY: Contains 1 SH2 domain.
WEB RESOURCE: Name=Wikipedia; Note=STAT3 entry; URL="http://en.wikipedia.org/wiki/STAT3";
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/STAT3ID444.html";
WEB RESOURCE: Name=STAT3base; Note=STAT3 mutation db; URL="http://bioinf.uta.fi/STAT3base/";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/stat3/";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STAT3
CDC HuGE Published Literature: STAT3
Positive Disease Associations: asthma , Crohn Disease , Crohn's disease , kidney cancer , multiple sclerosis
Related Studies:
  1. asthma
    Litonjua, A. A. et al. 2005, Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma., Respiratory research. 2005 Jun;6(1):52. [PubMed 15935090]
    Our results indicate that genetic variants in STAT3, independent of asthma treatment, are determinants of FEV1 in both adults and children with asthma, and suggest that STAT3 may participate in inflammatory pathways that have an impact on level of lung function.
  2. Crohn Disease
    Jeffrey C Barrett et al. Nature genetics 2008, Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease., Nature genetics. [PubMed 18587394]
  3. Crohn's disease
    Barrett ,et al. 2008, Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease, Nature genetics 2008 40- 8 : 955-62. [PubMed 18587394]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: STAT3
Diseases sorted by gene-association score: hyper-ige recurrent infection syndrome* (1668), autoimmune disease, multisystem, infantile-onset, 1* (1581), hyper ige syndrome* (429), diabetes mellitus, permanent neonatal* (143), t-cell large granular lymphocyte leukemia (25), bone squamous cell carcinoma (21), large granular lymphocyte leukemia (19), bone fracture (19), cervix carcinoma (12), anaplastic large cell lymphoma (11), pure red-cell aplasia (11), alk-positive anaplastic large cell lymphoma (11), pancreatic cancer (11), autoimmune enteropathy (11), mixed lacrimal gland cancer (10), hepatocellular carcinoma (10), inflammatory bowel disease (9), myeloproliferative neoplasm (9), hyperimmunoglobulin syndrome (9), eccrine porocarcinoma (8), skin carcinoma in situ (8), squamous cell carcinoma, head and neck (8), salivary gland cancer (8), chronic mucocutaneous candidiasis (7), hepatitis (7), mycosis fungoides (7), hepatitis c (6), lung cancer (6), apical myocardial infarction (6), prostate cancer (6), autoimmune lymphoproliferative syndrome (5), polycythemia vera, somatic (5), kaposi sarcoma (5), colonic disease (5), suppurative lymphadenitis (5), dermatitis (5), polyradiculoneuropathy (5), cellular congenital mesoblastic nephroma (5), colorectal cancer (4), malignant glioma (4), celiac disease (4), hepatitis c virus (3), nasopharyngeal carcinoma (3), chronic lymphocytic leukemia (3), diffuse large b-cell lymphoma (3), endometrial cancer (3), breast cancer (2), multiple myeloma (2), essential thrombocythemia (2), lung cancer susceptibility 3 (2), medulloblastoma (2), esophageal cancer (2), ovarian cancer, somatic (2), obesity (2), gastrointestinal system cancer (1), intestinal disease (1), leukemia, acute myeloid (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 64.96 RPKM in Lung
Total median expression: 1739.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -118.50240-0.494 Picture PostScript Text
3' UTR -887.252514-0.353 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR008967 - p53-like_TF_DNA-bd
IPR000980 - SH2
IPR013800 - STAT_TF_alpha
IPR015988 - STAT_TF_coiled-coil
IPR001217 - STAT_TF_core
IPR013801 - STAT_TF_DNA-bd
IPR012345 - STAT_TF_DNA-bd_sub
IPR013799 - STAT_TF_prot_interaction

Pfam Domains:
PF00017 - SH2 domain
PF01017 - STAT protein, all-alpha domain
PF02864 - STAT protein, DNA binding domain
PF02865 - STAT protein, protein interaction domain

SCOP Domains:
47655 - STAT
48092 - Transcription factor STAT-4 N-domain
49417 - p53-like transcription factors
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on P40763
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0004871 signal transducer activity
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031490 chromatin DNA binding
GO:0031730 CCR5 chemokine receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046983 protein dimerization activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001659 temperature homeostasis
GO:0001754 eye photoreceptor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007399 nervous system development
GO:0007568 aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010033 response to organic substance
GO:0010628 positive regulation of gene expression
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell population maintenance
GO:0019953 sexual reproduction
GO:0030522 intracellular receptor signaling pathway
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0033210 leptin-mediated signaling pathway
GO:0034097 response to cytokine
GO:0035019 somatic stem cell population maintenance
GO:0035278 miRNA mediated inhibition of translation
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0044320 cellular response to leptin stimulus
GO:0044321 response to leptin
GO:0045471 response to ethanol
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048708 astrocyte differentiation
GO:0051726 regulation of cell cycle
GO:0060019 radial glial cell differentiation
GO:0060259 regulation of feeding behavior
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 negative regulation of cell death
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0071345 cellular response to cytokine stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0072540 T-helper 17 cell lineage commitment
GO:0097009 energy homeostasis
GO:1901215 negative regulation of neuron death
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1904685 positive regulation of metalloendopeptidase activity
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000637 positive regulation of gene silencing by miRNA
GO:2000737 negative regulation of stem cell differentiation
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001223 negative regulation of neuron migration

Cellular Component:
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0090575 RNA polymerase II transcription factor complex


-  Descriptions from all associated GenBank mRNAs
  HW061238 - JP 2012529430-A/113: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JB252046 - Sequence 113 from Patent EP2440214.
LP764945 - Sequence 113 from Patent EP3276004.
HW061236 - JP 2012529430-A/111: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061237 - JP 2012529430-A/112: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JB252044 - Sequence 111 from Patent EP2440214.
JB252045 - Sequence 112 from Patent EP2440214.
LF384803 - JP 2014500723-A/192306: Polycomb-Associated Non-Coding RNAs.
LP764943 - Sequence 111 from Patent EP3276004.
LP764944 - Sequence 112 from Patent EP3276004.
BC014482 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone MGC:23173 IMAGE:4909141), complete cds.
AK297994 - Homo sapiens cDNA FLJ59362 complete cds, highly similar to Signal transducer and activator of transcription 3.
E10407 - cDNA encoding an acute phase response factor.
L29277 - Homo sapiens DNA-binding protein (APRF) mRNA, complete cds.
BC000627 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone MGC:1607 IMAGE:3347434), complete cds.
AK291933 - Homo sapiens cDNA FLJ78360 complete cds, highly similar to Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA.
AK316139 - Homo sapiens cDNA, FLJ79038 complete cds, highly similar to Signal transducer and activator of transcription 3.
AK301200 - Homo sapiens cDNA FLJ53413 complete cds, highly similar to Signal transducer and activator of transcription 3.
MA620380 - JP 2018138019-A/192306: Polycomb-Associated Non-Coding RNAs.
BC008044 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:3614611).
AK024535 - Homo sapiens cDNA: FLJ20882 fis, clone ADKA03206.
BC107775 - Homo sapiens cDNA clone IMAGE:6450121.
JD284514 - Sequence 265538 from Patent EP1572962.
BC067119 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:5539333).
JD275880 - Sequence 256904 from Patent EP1572962.
JD389446 - Sequence 370470 from Patent EP1572962.
JD295488 - Sequence 276512 from Patent EP1572962.
JD429338 - Sequence 410362 from Patent EP1572962.
JD078164 - Sequence 59188 from Patent EP1572962.
JD318494 - Sequence 299518 from Patent EP1572962.
JD350678 - Sequence 331702 from Patent EP1572962.
JD360010 - Sequence 341034 from Patent EP1572962.
JD424219 - Sequence 405243 from Patent EP1572962.
JD361060 - Sequence 342084 from Patent EP1572962.
JD211650 - Sequence 192674 from Patent EP1572962.
JD378494 - Sequence 359518 from Patent EP1572962.
JD552914 - Sequence 533938 from Patent EP1572962.
JD283141 - Sequence 264165 from Patent EP1572962.
JD368888 - Sequence 349912 from Patent EP1572962.
JD265271 - Sequence 246295 from Patent EP1572962.
JD066207 - Sequence 47231 from Patent EP1572962.
AK092965 - Homo sapiens cDNA FLJ35646 fis, clone SPLEN2012743.
JD217349 - Sequence 198373 from Patent EP1572962.
JD450937 - Sequence 431961 from Patent EP1572962.
JD534270 - Sequence 515294 from Patent EP1572962.
JD155619 - Sequence 136643 from Patent EP1572962.
JD059669 - Sequence 40693 from Patent EP1572962.
JD367534 - Sequence 348558 from Patent EP1572962.
JD381542 - Sequence 362566 from Patent EP1572962.
JD318861 - Sequence 299885 from Patent EP1572962.
JD364472 - Sequence 345496 from Patent EP1572962.
JD177392 - Sequence 158416 from Patent EP1572962.
JD305932 - Sequence 286956 from Patent EP1572962.
JD303138 - Sequence 284162 from Patent EP1572962.
JD360345 - Sequence 341369 from Patent EP1572962.
JD177390 - Sequence 158414 from Patent EP1572962.
JD522532 - Sequence 503556 from Patent EP1572962.
JD170064 - Sequence 151088 from Patent EP1572962.
JD529603 - Sequence 510627 from Patent EP1572962.
JD170065 - Sequence 151089 from Patent EP1572962.
JD529604 - Sequence 510628 from Patent EP1572962.
JD133669 - Sequence 114693 from Patent EP1572962.
JD430413 - Sequence 411437 from Patent EP1572962.
JD170063 - Sequence 151087 from Patent EP1572962.
JD293938 - Sequence 274962 from Patent EP1572962.
JD075851 - Sequence 56875 from Patent EP1572962.
JD454420 - Sequence 435444 from Patent EP1572962.
JD462462 - Sequence 443486 from Patent EP1572962.
JD538122 - Sequence 519146 from Patent EP1572962.
JD135475 - Sequence 116499 from Patent EP1572962.
JD392776 - Sequence 373800 from Patent EP1572962.
JD440233 - Sequence 421257 from Patent EP1572962.
JD185894 - Sequence 166918 from Patent EP1572962.
JD483112 - Sequence 464136 from Patent EP1572962.
JD261179 - Sequence 242203 from Patent EP1572962.
JD115894 - Sequence 96918 from Patent EP1572962.
JD269150 - Sequence 250174 from Patent EP1572962.
LF327829 - JP 2014500723-A/135332: Polycomb-Associated Non-Coding RNAs.
LF327830 - JP 2014500723-A/135333: Polycomb-Associated Non-Coding RNAs.
AJ012463 - Homo sapiens mRNA for transcription factor.
EU831439 - Synthetic construct Homo sapiens clone HAIB:100066468; DKFZo008D0317 signal transducer and activator of transcription 3 (acute-phase response factor) protein (STAT3) gene, encodes complete protein.
EU831531 - Synthetic construct Homo sapiens clone HAIB:100066560; DKFZo004D0318 signal transducer and activator of transcription 3 (acute-phase response factor) protein (STAT3) gene, encodes complete protein.
KJ892215 - Synthetic construct Homo sapiens clone ccsbBroadEn_01609 STAT3 gene, encodes complete protein.
KR710553 - Synthetic construct Homo sapiens clone CCSBHm_00014012 STAT3 (STAT3) mRNA, encodes complete protein.
KR710554 - Synthetic construct Homo sapiens clone CCSBHm_00014014 STAT3 (STAT3) mRNA, encodes complete protein.
KR710555 - Synthetic construct Homo sapiens clone CCSBHm_00014026 STAT3 (STAT3) mRNA, encodes complete protein.
KR710556 - Synthetic construct Homo sapiens clone CCSBHm_00014029 STAT3 (STAT3) mRNA, encodes complete protein.
AB451232 - Homo sapiens STAT3 mRNA for signal transducer and activator of transcription 3 isoform 2, complete cds, clone: FLJ08023AAAN.
EU446657 - Synthetic construct Homo sapiens clone IMAGE:100070191; IMAGE:100011866; FLH258221.01L signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3) gene, encodes complete protein.
KJ905931 - Synthetic construct Homo sapiens clone ccsbBroadEn_15601 STAT3 gene, encodes complete protein.
AB385032 - Synthetic construct DNA, clone: pF1KB5090, Homo sapiens STAT3 gene for signal transducer and activator of transcription 3, complete cds, without stop codon, in Flexi system.
AM393108 - Synthetic construct Homo sapiens clone IMAGE:100002407 for hypothetical protein (STAT3 gene).
AF029311 - Homo sapiens signal transducer and activator of transcription 3 (STAT3) mRNA, partial cds.
LF327834 - JP 2014500723-A/135337: Polycomb-Associated Non-Coding RNAs.
LF327835 - JP 2014500723-A/135338: Polycomb-Associated Non-Coding RNAs.
LF327837 - JP 2014500723-A/135340: Polycomb-Associated Non-Coding RNAs.
LF327838 - JP 2014500723-A/135341: Polycomb-Associated Non-Coding RNAs.
CU674306 - Synthetic construct Homo sapiens gateway clone IMAGE:100017809 5' read STAT3 mRNA.
LF327839 - JP 2014500723-A/135342: Polycomb-Associated Non-Coding RNAs.
LF327840 - JP 2014500723-A/135343: Polycomb-Associated Non-Coding RNAs.
CU677019 - Synthetic construct Homo sapiens gateway clone IMAGE:100017489 5' read STAT3 mRNA.
LF327841 - JP 2014500723-A/135344: Polycomb-Associated Non-Coding RNAs.
LF327842 - JP 2014500723-A/135345: Polycomb-Associated Non-Coding RNAs.
LF327843 - JP 2014500723-A/135346: Polycomb-Associated Non-Coding RNAs.
JD561207 - Sequence 542231 from Patent EP1572962.
MA563406 - JP 2018138019-A/135332: Polycomb-Associated Non-Coding RNAs.
MA563407 - JP 2018138019-A/135333: Polycomb-Associated Non-Coding RNAs.
MA563411 - JP 2018138019-A/135337: Polycomb-Associated Non-Coding RNAs.
MA563412 - JP 2018138019-A/135338: Polycomb-Associated Non-Coding RNAs.
MA563414 - JP 2018138019-A/135340: Polycomb-Associated Non-Coding RNAs.
MA563415 - JP 2018138019-A/135341: Polycomb-Associated Non-Coding RNAs.
MA563416 - JP 2018138019-A/135342: Polycomb-Associated Non-Coding RNAs.
MA563417 - JP 2018138019-A/135343: Polycomb-Associated Non-Coding RNAs.
MA563418 - JP 2018138019-A/135344: Polycomb-Associated Non-Coding RNAs.
MA563419 - JP 2018138019-A/135345: Polycomb-Associated Non-Coding RNAs.
MA563420 - JP 2018138019-A/135346: Polycomb-Associated Non-Coding RNAs.
BC029783 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:5193339), with apparent retained intron.
JD542097 - Sequence 523121 from Patent EP1572962.
JD560848 - Sequence 541872 from Patent EP1572962.
JD365717 - Sequence 346741 from Patent EP1572962.
JD394759 - Sequence 375783 from Patent EP1572962.
JD069197 - Sequence 50221 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04062 - Chemokine signaling pathway
hsa04630 - Jak-STAT signaling pathway
hsa04920 - Adipocytokine signaling pathway
hsa05200 - Pathways in cancer
hsa05212 - Pancreatic cancer
hsa05221 - Acute myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_il6Pathway - IL 6 signaling pathway
h_pdgfPathway - PDGF Signaling Pathway
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_egfPathway - EGF Signaling Pathway
h_il10Pathway - IL-10 Anti-inflammatory Signaling Pathway
h_TPOPathway - TPO Signaling Pathway
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_stat3Pathway - Stat3 Signaling Pathway
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_il22bppathway - IL22 Soluble Receptor Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P40763 (Reactome details) participates in the following event(s):

R-HSA-198732 STAT3 activation
R-HSA-2671868 Phosphorylated LEPR Binds STAT3
R-HSA-6784323 IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
R-HSA-8848087 STAP2 recruits STAT3 to PTK6
R-HSA-8875816 STAT3 binds activated MET receptor
R-HSA-2730595 Phosphorylated STAT3 Forms Dimers
R-HSA-8950780 p-Y705-STAT3 binds p-Y693-STAT4
R-HSA-8950782 p-STAT1 binds p-STAT3
R-HSA-2671839 Phosphorylated STAT3 Dissociates from Leptin Receptor
R-HSA-6784791 p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
R-HSA-8848124 PTK6 phosphorylates STAT3
R-HSA-8875817 MET phosphorylates STAT3
R-HSA-2671850 JAK2 Phosphoryates STAT3 in Response to Leptin
R-HSA-6784006 STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
R-HSA-8982163 IL19:IL20RA:p‑JAK1:IL20RB:STAT3 phosphorylates STAT3
R-HSA-380782 STAT binds to the active receptor
R-HSA-1112565 Tyrosine phosphorylated IL6ST binds STAT1,STAT3
R-HSA-1168768 JAK2 binds STAT1/3
R-HSA-1433456 Recruitment of STATs
R-HSA-1888198 FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
R-HSA-6786124 STAT3,STAT6 bind p-Y-IL4R
R-HSA-6788571 STAT1,STAT3,STAT6 bind IL13:IL13R type II
R-HSA-1112538 Phosphorylated STAT1, STAT3 form dimers
R-HSA-1112604 Phosphorylated STATs are released
R-HSA-2895778 POU5F1 (OCT4), STAT3 bind the SALL4 promoter
R-HSA-8848150 STAT3 binds SOCS3 promoter
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
R-HSA-1112602 Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
R-HSA-1168767 JAK2 phosphorylates STAT1/STAT3
R-HSA-6786095 JAK1 phosphorylates STAT3,STAT6
R-HSA-6788582 STAT1,STAT3,STAT6 phosphorylation
R-HSA-1470010 Dimerization of STATs
R-HSA-1470012 Disassociation and translocation of STATs to the nucleus
R-HSA-198745 Signalling to STAT3
R-HSA-2586552 Signaling by Leptin
R-HSA-6783783 Interleukin-10 signaling
R-HSA-8849474 PTK6 Activates STAT3
R-HSA-8875791 MET activates STAT3
R-HSA-9020956 Interleukin-27 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9008059 Interleukin-37 signaling
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-8983432 Interleukin-15 signaling
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-186763 Downstream signal transduction
R-HSA-1059683 Interleukin-6 signaling
R-HSA-982772 Growth hormone receptor signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-162582 Signal Transduction
R-HSA-449147 Signaling by Interleukins
R-HSA-8848021 Signaling by PTK6
R-HSA-6806834 Signaling by MET
R-HSA-447115 Interleukin-12 family signaling
R-HSA-446652 Interleukin-1 family signaling
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-451927 Interleukin-2 family signaling
R-HSA-166520 Signaling by NTRKs
R-HSA-186797 Signaling by PDGF
R-HSA-6783589 Interleukin-6 family signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-1266738 Developmental Biology
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-168256 Immune System
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-391251 Protein folding
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-392499 Metabolism of proteins
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7B8, APRF, NM_213662, NP_998827, O14916, P40763, Q9BW54, STAT3_HUMAN
UCSC ID: uc002hzk.1
RefSeq Accession: NM_213662
Protein: P40763 (aka STAT3_HUMAN or STA3_HUMAN)
CCDS: CCDS59288.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene STAT3:
higes (STAT3 Hyper IgE Syndrome)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_213662.1
exon count: 24CDS single in 3' UTR: no RNA size: 4819
ORF size: 2169CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4538.00frame shift in genome: no % Coverage: 99.92
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.