Human Gene STAT3 (uc002hzm.1) Description and Page Index
  Description: Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 2, mRNA.
RefSeq Summary (NM_003150): The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015].
Transcript (Including UTRs)
   Position: hg19 chr17:40,465,343-40,540,513 Size: 75,171 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr17:40,467,763-40,500,534 Size: 32,772 Coding Exon Count: 23 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesGeneReviewsModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:40,465,343-40,540,513)mRNA (may differ from genome)Protein (769 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STAT3
CDC HuGE Published Literature: STAT3
Positive Disease Associations: asthma , Crohn Disease , Crohn's disease , kidney cancer , multiple sclerosis
Related Studies:
  1. asthma
    Litonjua, A. A. et al. 2005, Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma., Respiratory research. 2005 Jun;6(1):52. [PubMed 15935090]
    Our results indicate that genetic variants in STAT3, independent of asthma treatment, are determinants of FEV1 in both adults and children with asthma, and suggest that STAT3 may participate in inflammatory pathways that have an impact on level of lung function.
  2. Crohn Disease
    Jeffrey C Barrett et al. Nature genetics 2008, Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease., Nature genetics. [PubMed 18587394]
  3. Crohn's disease
    Barrett ,et al. 2008, Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease, Nature genetics 2008 40- 8 : 955-62. [PubMed 18587394]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: STAT3
Diseases sorted by gene-association score: hyper-ige recurrent infection syndrome* (1668), autoimmune disease, multisystem, infantile-onset, 1* (1581), hyper ige syndrome* (429), diabetes mellitus, permanent neonatal* (143), t-cell large granular lymphocyte leukemia (25), bone squamous cell carcinoma (21), large granular lymphocyte leukemia (19), bone fracture (19), cervix carcinoma (12), anaplastic large cell lymphoma (11), pure red-cell aplasia (11), alk-positive anaplastic large cell lymphoma (11), pancreatic cancer (11), autoimmune enteropathy (11), mixed lacrimal gland cancer (10), hepatocellular carcinoma (10), inflammatory bowel disease (9), myeloproliferative neoplasm (9), hyperimmunoglobulin syndrome (9), eccrine porocarcinoma (8), skin carcinoma in situ (8), squamous cell carcinoma, head and neck (8), salivary gland cancer (8), chronic mucocutaneous candidiasis (7), hepatitis (7), mycosis fungoides (7), hepatitis c (6), lung cancer (6), apical myocardial infarction (6), prostate cancer (6), autoimmune lymphoproliferative syndrome (5), polycythemia vera, somatic (5), kaposi sarcoma (5), colonic disease (5), suppurative lymphadenitis (5), dermatitis (5), polyradiculoneuropathy (5), cellular congenital mesoblastic nephroma (5), colorectal cancer (4), malignant glioma (4), celiac disease (4), hepatitis c virus (3), nasopharyngeal carcinoma (3), chronic lymphocytic leukemia (3), diffuse large b-cell lymphoma (3), endometrial cancer (3), breast cancer (2), multiple myeloma (2), essential thrombocythemia (2), lung cancer susceptibility 3 (2), medulloblastoma (2), esophageal cancer (2), ovarian cancer, somatic (2), obesity (2), gastrointestinal system cancer (1), intestinal disease (1), leukemia, acute myeloid (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 64.96 RPKM in Lung
Total median expression: 1739.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.10218-0.519 Picture PostScript Text
3' UTR -849.262420-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00017 - SH2 domain
PF01017 - STAT protein, all-alpha domain
PF02864 - STAT protein, DNA binding domain
PF02865 - STAT protein, protein interaction domain

SCOP Domains:
47655 - STAT
48092 - Transcription factor STAT-4 N-domain
49417 - p53-like transcription factors
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on P40763-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  HW061238 - JP 2012529430-A/113: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JB252046 - Sequence 113 from Patent EP2440214.
LP764945 - Sequence 113 from Patent EP3276004.
HW061236 - JP 2012529430-A/111: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061237 - JP 2012529430-A/112: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JB252044 - Sequence 111 from Patent EP2440214.
JB252045 - Sequence 112 from Patent EP2440214.
LF384803 - JP 2014500723-A/192306: Polycomb-Associated Non-Coding RNAs.
LP764943 - Sequence 111 from Patent EP3276004.
LP764944 - Sequence 112 from Patent EP3276004.
BC014482 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone MGC:23173 IMAGE:4909141), complete cds.
AK297994 - Homo sapiens cDNA FLJ59362 complete cds, highly similar to Signal transducer and activator of transcription 3.
E10407 - cDNA encoding an acute phase response factor.
L29277 - Homo sapiens DNA-binding protein (APRF) mRNA, complete cds.
BC000627 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone MGC:1607 IMAGE:3347434), complete cds.
AK291933 - Homo sapiens cDNA FLJ78360 complete cds, highly similar to Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA.
AK316139 - Homo sapiens cDNA, FLJ79038 complete cds, highly similar to Signal transducer and activator of transcription 3.
AK301200 - Homo sapiens cDNA FLJ53413 complete cds, highly similar to Signal transducer and activator of transcription 3.
MA620380 - JP 2018138019-A/192306: Polycomb-Associated Non-Coding RNAs.
BC008044 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:3614611).
AK024535 - Homo sapiens cDNA: FLJ20882 fis, clone ADKA03206.
BC107775 - Homo sapiens cDNA clone IMAGE:6450121.
JD284514 - Sequence 265538 from Patent EP1572962.
BC067119 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:5539333).
JD275880 - Sequence 256904 from Patent EP1572962.
JD389446 - Sequence 370470 from Patent EP1572962.
JD295488 - Sequence 276512 from Patent EP1572962.
JD429338 - Sequence 410362 from Patent EP1572962.
JD078164 - Sequence 59188 from Patent EP1572962.
JD318494 - Sequence 299518 from Patent EP1572962.
JD350678 - Sequence 331702 from Patent EP1572962.
JD360010 - Sequence 341034 from Patent EP1572962.
JD424219 - Sequence 405243 from Patent EP1572962.
JD361060 - Sequence 342084 from Patent EP1572962.
JD211650 - Sequence 192674 from Patent EP1572962.
JD378494 - Sequence 359518 from Patent EP1572962.
JD552914 - Sequence 533938 from Patent EP1572962.
JD283141 - Sequence 264165 from Patent EP1572962.
JD368888 - Sequence 349912 from Patent EP1572962.
JD265271 - Sequence 246295 from Patent EP1572962.
JD066207 - Sequence 47231 from Patent EP1572962.
AK092965 - Homo sapiens cDNA FLJ35646 fis, clone SPLEN2012743.
JD217349 - Sequence 198373 from Patent EP1572962.
JD450937 - Sequence 431961 from Patent EP1572962.
JD534270 - Sequence 515294 from Patent EP1572962.
JD155619 - Sequence 136643 from Patent EP1572962.
JD059669 - Sequence 40693 from Patent EP1572962.
JD367534 - Sequence 348558 from Patent EP1572962.
JD381542 - Sequence 362566 from Patent EP1572962.
JD318861 - Sequence 299885 from Patent EP1572962.
JD364472 - Sequence 345496 from Patent EP1572962.
JD177392 - Sequence 158416 from Patent EP1572962.
JD305932 - Sequence 286956 from Patent EP1572962.
JD303138 - Sequence 284162 from Patent EP1572962.
JD360345 - Sequence 341369 from Patent EP1572962.
JD177390 - Sequence 158414 from Patent EP1572962.
JD522532 - Sequence 503556 from Patent EP1572962.
JD170064 - Sequence 151088 from Patent EP1572962.
JD529603 - Sequence 510627 from Patent EP1572962.
JD170065 - Sequence 151089 from Patent EP1572962.
JD529604 - Sequence 510628 from Patent EP1572962.
JD133669 - Sequence 114693 from Patent EP1572962.
JD430413 - Sequence 411437 from Patent EP1572962.
JD170063 - Sequence 151087 from Patent EP1572962.
JD293938 - Sequence 274962 from Patent EP1572962.
JD075851 - Sequence 56875 from Patent EP1572962.
JD454420 - Sequence 435444 from Patent EP1572962.
JD462462 - Sequence 443486 from Patent EP1572962.
JD538122 - Sequence 519146 from Patent EP1572962.
JD135475 - Sequence 116499 from Patent EP1572962.
JD392776 - Sequence 373800 from Patent EP1572962.
JD440233 - Sequence 421257 from Patent EP1572962.
JD185894 - Sequence 166918 from Patent EP1572962.
JD483112 - Sequence 464136 from Patent EP1572962.
JD261179 - Sequence 242203 from Patent EP1572962.
JD115894 - Sequence 96918 from Patent EP1572962.
JD269150 - Sequence 250174 from Patent EP1572962.
LF327829 - JP 2014500723-A/135332: Polycomb-Associated Non-Coding RNAs.
LF327830 - JP 2014500723-A/135333: Polycomb-Associated Non-Coding RNAs.
AJ012463 - Homo sapiens mRNA for transcription factor.
EU831439 - Synthetic construct Homo sapiens clone HAIB:100066468; DKFZo008D0317 signal transducer and activator of transcription 3 (acute-phase response factor) protein (STAT3) gene, encodes complete protein.
EU831531 - Synthetic construct Homo sapiens clone HAIB:100066560; DKFZo004D0318 signal transducer and activator of transcription 3 (acute-phase response factor) protein (STAT3) gene, encodes complete protein.
KJ892215 - Synthetic construct Homo sapiens clone ccsbBroadEn_01609 STAT3 gene, encodes complete protein.
KR710553 - Synthetic construct Homo sapiens clone CCSBHm_00014012 STAT3 (STAT3) mRNA, encodes complete protein.
KR710554 - Synthetic construct Homo sapiens clone CCSBHm_00014014 STAT3 (STAT3) mRNA, encodes complete protein.
KR710555 - Synthetic construct Homo sapiens clone CCSBHm_00014026 STAT3 (STAT3) mRNA, encodes complete protein.
KR710556 - Synthetic construct Homo sapiens clone CCSBHm_00014029 STAT3 (STAT3) mRNA, encodes complete protein.
AB451232 - Homo sapiens STAT3 mRNA for signal transducer and activator of transcription 3 isoform 2, complete cds, clone: FLJ08023AAAN.
EU446657 - Synthetic construct Homo sapiens clone IMAGE:100070191; IMAGE:100011866; FLH258221.01L signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3) gene, encodes complete protein.
KJ905931 - Synthetic construct Homo sapiens clone ccsbBroadEn_15601 STAT3 gene, encodes complete protein.
AB385032 - Synthetic construct DNA, clone: pF1KB5090, Homo sapiens STAT3 gene for signal transducer and activator of transcription 3, complete cds, without stop codon, in Flexi system.
AM393108 - Synthetic construct Homo sapiens clone IMAGE:100002407 for hypothetical protein (STAT3 gene).
AF029311 - Homo sapiens signal transducer and activator of transcription 3 (STAT3) mRNA, partial cds.
LF327834 - JP 2014500723-A/135337: Polycomb-Associated Non-Coding RNAs.
LF327835 - JP 2014500723-A/135338: Polycomb-Associated Non-Coding RNAs.
LF327837 - JP 2014500723-A/135340: Polycomb-Associated Non-Coding RNAs.
LF327838 - JP 2014500723-A/135341: Polycomb-Associated Non-Coding RNAs.
CU674306 - Synthetic construct Homo sapiens gateway clone IMAGE:100017809 5' read STAT3 mRNA.
LF327839 - JP 2014500723-A/135342: Polycomb-Associated Non-Coding RNAs.
LF327840 - JP 2014500723-A/135343: Polycomb-Associated Non-Coding RNAs.
CU677019 - Synthetic construct Homo sapiens gateway clone IMAGE:100017489 5' read STAT3 mRNA.
LF327841 - JP 2014500723-A/135344: Polycomb-Associated Non-Coding RNAs.
LF327842 - JP 2014500723-A/135345: Polycomb-Associated Non-Coding RNAs.
LF327843 - JP 2014500723-A/135346: Polycomb-Associated Non-Coding RNAs.
MA563406 - JP 2018138019-A/135332: Polycomb-Associated Non-Coding RNAs.
MA563407 - JP 2018138019-A/135333: Polycomb-Associated Non-Coding RNAs.
MA563411 - JP 2018138019-A/135337: Polycomb-Associated Non-Coding RNAs.
MA563412 - JP 2018138019-A/135338: Polycomb-Associated Non-Coding RNAs.
MA563414 - JP 2018138019-A/135340: Polycomb-Associated Non-Coding RNAs.
MA563415 - JP 2018138019-A/135341: Polycomb-Associated Non-Coding RNAs.
MA563416 - JP 2018138019-A/135342: Polycomb-Associated Non-Coding RNAs.
MA563417 - JP 2018138019-A/135343: Polycomb-Associated Non-Coding RNAs.
MA563418 - JP 2018138019-A/135344: Polycomb-Associated Non-Coding RNAs.
MA563419 - JP 2018138019-A/135345: Polycomb-Associated Non-Coding RNAs.
MA563420 - JP 2018138019-A/135346: Polycomb-Associated Non-Coding RNAs.
BC029783 - Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA (cDNA clone IMAGE:5193339), with apparent retained intron.
JD542097 - Sequence 523121 from Patent EP1572962.
JD560848 - Sequence 541872 from Patent EP1572962.
JD365717 - Sequence 346741 from Patent EP1572962.
JD394759 - Sequence 375783 from Patent EP1572962.
JD069197 - Sequence 50221 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04062 - Chemokine signaling pathway
hsa04630 - Jak-STAT signaling pathway
hsa04920 - Adipocytokine signaling pathway
hsa05200 - Pathways in cancer
hsa05212 - Pancreatic cancer
hsa05221 - Acute myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_il6Pathway - IL 6 signaling pathway
h_pdgfPathway - PDGF Signaling Pathway
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_egfPathway - EGF Signaling Pathway
h_il10Pathway - IL-10 Anti-inflammatory Signaling Pathway
h_TPOPathway - TPO Signaling Pathway
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_stat3Pathway - Stat3 Signaling Pathway
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_il22bppathway - IL22 Soluble Receptor Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P40763 (Reactome details) participates in the following event(s):

R-HSA-198732 STAT3 activation
R-HSA-2671868 Phosphorylated LEPR Binds STAT3
R-HSA-6784323 IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
R-HSA-8848087 STAP2 recruits STAT3 to PTK6
R-HSA-8875816 STAT3 binds activated MET receptor
R-HSA-2730595 Phosphorylated STAT3 Forms Dimers
R-HSA-8950780 p-Y705-STAT3 binds p-Y693-STAT4
R-HSA-8950782 p-STAT1 binds p-STAT3
R-HSA-2671839 Phosphorylated STAT3 Dissociates from Leptin Receptor
R-HSA-6784791 p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
R-HSA-8848124 PTK6 phosphorylates STAT3
R-HSA-8875817 MET phosphorylates STAT3
R-HSA-2671850 JAK2 Phosphoryates STAT3 in Response to Leptin
R-HSA-6784006 STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
R-HSA-8982163 IL19:IL20RA:p‑JAK1:IL20RB:STAT3 phosphorylates STAT3
R-HSA-380782 STAT binds to the active receptor
R-HSA-1112565 Tyrosine phosphorylated IL6ST binds STAT1,STAT3
R-HSA-1168768 JAK2 binds STAT1/3
R-HSA-1433456 Recruitment of STATs
R-HSA-1888198 FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
R-HSA-6786124 STAT3,STAT6 bind p-Y-IL4R
R-HSA-6788571 STAT1,STAT3,STAT6 bind IL13:IL13R type II
R-HSA-1112538 Phosphorylated STAT1, STAT3 form dimers
R-HSA-1112604 Phosphorylated STATs are released
R-HSA-2895778 POU5F1 (OCT4), STAT3 bind the SALL4 promoter
R-HSA-8848150 STAT3 binds SOCS3 promoter
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
R-HSA-1112602 Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
R-HSA-1168767 JAK2 phosphorylates STAT1/STAT3
R-HSA-6786095 JAK1 phosphorylates STAT3,STAT6
R-HSA-6788582 STAT1,STAT3,STAT6 phosphorylation
R-HSA-1470010 Dimerization of STATs
R-HSA-1470012 Disassociation and translocation of STATs to the nucleus
R-HSA-198745 Signalling to STAT3
R-HSA-2586552 Signaling by Leptin
R-HSA-6783783 Interleukin-10 signaling
R-HSA-8849474 PTK6 Activates STAT3
R-HSA-8875791 MET activates STAT3
R-HSA-9020956 Interleukin-27 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9008059 Interleukin-37 signaling
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-8983432 Interleukin-15 signaling
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-186763 Downstream signal transduction
R-HSA-1059683 Interleukin-6 signaling
R-HSA-982772 Growth hormone receptor signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-162582 Signal Transduction
R-HSA-449147 Signaling by Interleukins
R-HSA-8848021 Signaling by PTK6
R-HSA-6806834 Signaling by MET
R-HSA-447115 Interleukin-12 family signaling
R-HSA-446652 Interleukin-1 family signaling
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-451927 Interleukin-2 family signaling
R-HSA-166520 Signaling by NTRKs
R-HSA-186797 Signaling by PDGF
R-HSA-6783589 Interleukin-6 family signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-1266738 Developmental Biology
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-168256 Immune System
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-391251 Protein folding
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-392499 Metabolism of proteins
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: APRF, NM_003150, NP_003141, P40763-2
UCSC ID: uc002hzm.1
RefSeq Accession: NM_003150
Protein: P40763-2, splice isoform of P40763 CCDS: CCDS32656.1, CCDS32657.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene STAT3:
higes (STAT3 Hyper IgE Syndrome)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003150.3
exon count: 24CDS single in 3' UTR: no RNA size: 4953
ORF size: 2310CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4820.00frame shift in genome: no % Coverage: 99.90
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.