Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CUEDC1 CDC HuGE Published Literature: CUEDC1 Positive Disease Associations: Multiple Sclerosis Related Studies:
Multiple Sclerosis Sergio E Baranzini et al. Brain : a journal of neurology 2010, Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis., Brain : a journal of neurology.
from these analyses indicated that variance in the activity of neurochemical pathways implicated in neurodegeneration is explained, at least in part, by the inheritance of common genetic polymorphisms.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NWM3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.