Human Gene CUEDC1 (uc002ivd.2) Description and Page Index
  Description: Homo sapiens CUE domain containing 1 (CUEDC1), transcript variant 2, non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr17:55,938,604-55,980,750 Size: 42,147 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr17:55,943,838-55,962,925 Size: 19,088 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:55,938,604-55,980,750)mRNA (may differ from genome)Protein (386 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCHPRDLynxMGIneXtProtPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CUED1_HUMAN
DESCRIPTION: RecName: Full=CUE domain-containing protein 1;
SIMILARITY: Contains 1 CUE domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CUEDC1
CDC HuGE Published Literature: CUEDC1
Positive Disease Associations: Multiple Sclerosis
Related Studies:
  1. Multiple Sclerosis
    Sergio E Baranzini et al. Brain : a journal of neurology 2010, Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis., Brain : a journal of neurology. [PubMed 20802204]
    from these analyses indicated that variance in the activity of neurochemical pathways implicated in neurodegeneration is explained, at least in part, by the inheritance of common genetic polymorphisms.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.79 RPKM in Colon - Sigmoid
Total median expression: 606.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -336.16719-0.468 Picture PostScript Text
3' UTR -953.802046-0.466 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003892 - CUE
IPR009060 - UBA-like

Pfam Domains:
PF02845 - CUE domain

SCOP Domains:
46934 - UBA-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DHY
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9NWM3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC056882 - Homo sapiens CUE domain containing 1, mRNA (cDNA clone MGC:65000 IMAGE:6150503), complete cds.
AK000746 - Homo sapiens cDNA FLJ20739 fis, clone HEP07341.
BC008034 - Homo sapiens cDNA clone IMAGE:2967039, **** WARNING: chimeric clone ****.
CR627470 - Homo sapiens mRNA; cDNA DKFZp547L163 (from clone DKFZp547L163).
AK000977 - Homo sapiens cDNA FLJ10115 fis, clone HEMBA1002777.
JD132312 - Sequence 113336 from Patent EP1572962.
JD228997 - Sequence 210021 from Patent EP1572962.
JD354091 - Sequence 335115 from Patent EP1572962.
KJ900749 - Synthetic construct Homo sapiens clone ccsbBroadEn_10143 CUEDC1 gene, encodes complete protein.
JD476271 - Sequence 457295 from Patent EP1572962.
JD128504 - Sequence 109528 from Patent EP1572962.
JD055094 - Sequence 36118 from Patent EP1572962.
JD383449 - Sequence 364473 from Patent EP1572962.
JD432802 - Sequence 413826 from Patent EP1572962.
JD373534 - Sequence 354558 from Patent EP1572962.
JD464696 - Sequence 445720 from Patent EP1572962.
JD240070 - Sequence 221094 from Patent EP1572962.
JD088439 - Sequence 69463 from Patent EP1572962.
JD282721 - Sequence 263745 from Patent EP1572962.
JD541662 - Sequence 522686 from Patent EP1572962.
JD398947 - Sequence 379971 from Patent EP1572962.
JD079039 - Sequence 60063 from Patent EP1572962.
JD346884 - Sequence 327908 from Patent EP1572962.
JD308333 - Sequence 289357 from Patent EP1572962.
JD504349 - Sequence 485373 from Patent EP1572962.
JD157066 - Sequence 138090 from Patent EP1572962.
JD312453 - Sequence 293477 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CUED1_HUMAN, D3DTZ2, NM_001271875, NP_001258804, NR_073495, Q9NWD0, Q9NWM3, uc002ivd.1
UCSC ID: uc002ivd.2
RefSeq Accession: NM_001271875
Protein: Q9NWM3 (aka CUED1_HUMAN or CUE1_HUMAN)
CCDS: CCDS11599.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_073495.1
exon count: 11CDS single in 3' UTR: no RNA size: 3943
ORF size: 1161CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2074.00frame shift in genome: no % Coverage: 99.57
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.