Human Gene MFSD11 (uc002jta.2) Description and Page Index
Description: Homo sapiens major facilitator superfamily domain containing 11 (MFSD11), transcript variant 3, mRNA.
Transcript (Including UTRs)
Position: hg19 chr17:74,732,272-74,775,336 Size: 43,065 Total Exon Count: 14 Strand: +
Position: hg19 chr17:74,734,435-74,774,434 Size: 40,000 Coding Exon Count: 13
Data last updated: 2013-06-15
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=UNC93-like protein MFSD11; AltName: Full=Major facilitator superfamily domain-containing protein 11; AltName: Full=Protein ET;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the unc-93 family. CAUTION: Despite its name, it is related to the unc-93 family and not to the major facilitator superfamily.
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR010291 - Ion_channel_UNC-93
IPR016196 - MFS_dom_general_subst_transpt
Pfam Domains: PF05978 - Ion channel regulatory protein UNC-93
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on O43934
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF209428 - JP 2014500723-A/16931: Polycomb-Associated Non-Coding RNAs. CU688225 - Synthetic construct Homo sapiens gateway clone IMAGE:100021020 3' read SFRS2 mRNA. AF015188 - Homo sapiens clone ET42 ET mRNA, alternatively spliced partial sequence. LF328459 - JP 2014500723-A/135962: Polycomb-Associated Non-Coding RNAs. AF015189 - Homo sapiens clone ET51 ET mRNA, alternatively spliced partial sequence. LF328460 - JP 2014500723-A/135963: Polycomb-Associated Non-Coding RNAs. HZ483494 - JP 2015535430-A/4000: TERMINALLY MODIFIED RNA. HZ793425 - JP 2016504050-A/5170: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. JC516157 - Sequence 6410 from Patent WO2014113089. LQ073745 - Sequence 4069 from Patent EP2964234. AF015190 - Homo sapiens clone ET61 ET mRNA, alternatively spliced partial sequence. AF015187 - Homo sapiens clone ET32 ET mRNA, alternatively spliced partial sequence. AF015186 - Homo sapiens clone ET22 ET putative translation product (ET) mRNA, alternatively spliced complete cds. AF015183 - Homo sapiens clone ET12 ET mRNA, alternatively spliced partial sequence. AF015185 - Homo sapiens clone ET10 ET putative translation product (ET) mRNA, alternatively spliced complete cds. BC002753 - Homo sapiens major facilitator superfamily domain containing 11, mRNA (cDNA clone MGC:3827 IMAGE:3629029), complete cds. BC062563 - Homo sapiens major facilitator superfamily domain containing 11, mRNA (cDNA clone MGC:74917 IMAGE:5140496), complete cds. AK308058 - Homo sapiens cDNA, FLJ98006. AF015184 - Homo sapiens clone ET16 ET putative translation product (ET) mRNA, alternatively spliced complete cds. AK000233 - Homo sapiens cDNA FLJ20226 fis, clone COLF5064. JD178137 - Sequence 159161 from Patent EP1572962. KJ894665 - Synthetic construct Homo sapiens clone ccsbBroadEn_04059 MFSD11 gene, encodes complete protein. CU678164 - Synthetic construct Homo sapiens gateway clone IMAGE:100019455 5' read MFSD11 mRNA. DQ896233 - Synthetic construct Homo sapiens clone IMAGE:100010693; FLH191405.01L; RZPDo839C1167D hypothetical protein ET (ET) gene, encodes complete protein. AK025849 - Homo sapiens cDNA: FLJ22196 fis, clone HRC01180, highly similar to AF015184 Homo sapiens clone ET16 ET putative translation product (ET) mRNA. JD022794 - Sequence 3818 from Patent EP1572962. JD033667 - Sequence 14691 from Patent EP1572962. JD061322 - Sequence 42346 from Patent EP1572962. JD311005 - Sequence 292029 from Patent EP1572962. JD358609 - Sequence 339633 from Patent EP1572962. JD451947 - Sequence 432971 from Patent EP1572962. JD240876 - Sequence 221900 from Patent EP1572962. JD467965 - Sequence 448989 from Patent EP1572962. MA647246 - JP 2017113010-A/5170: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA735130 - JP 2017140048-A/4000: TERMINALLY MODIFIED RNA. MA564036 - JP 2018138019-A/135962: Polycomb-Associated Non-Coding RNAs. MA564037 - JP 2018138019-A/135963: Polycomb-Associated Non-Coding RNAs. MA445005 - JP 2018138019-A/16931: Polycomb-Associated Non-Coding RNAs. MA804299 - JP 2018183181-A/5170: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
Other Names for This Gene
Alternate Gene Symbols: ET, MFS11_HUMAN, NM_001242534, NP_077287, O43442, O43934, Q9NXI5 UCSC ID: uc002jta.2 RefSeq Accession: NM_001242534
(aka MFS11_HUMAN) O43934
Gene Model Information
14 CDS single in 3' UTR:
1350 CDS single in intron:
Alignment % ID:
2645.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.