Human Gene MFSD11 (uc002jta.2) Description and Page Index
  Description: Homo sapiens major facilitator superfamily domain containing 11 (MFSD11), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:74,732,272-74,775,336 Size: 43,065 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr17:74,734,435-74,774,434 Size: 40,000 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:74,732,272-74,775,336)mRNA (may differ from genome)Protein (449 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsH-INVHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE
TreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MFS11_HUMAN
DESCRIPTION: RecName: Full=UNC93-like protein MFSD11; AltName: Full=Major facilitator superfamily domain-containing protein 11; AltName: Full=Protein ET;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the unc-93 family.
CAUTION: Despite its name, it is related to the unc-93 family and not to the major facilitator superfamily.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.12 RPKM in Pituitary
Total median expression: 266.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -499.20973-0.513 Picture PostScript Text
3' UTR -298.21902-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010291 - Ion_channel_UNC-93
IPR016196 - MFS_dom_general_subst_transpt

Pfam Domains:
PF05978 - Ion channel regulatory protein UNC-93

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on O43934
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF209428 - JP 2014500723-A/16931: Polycomb-Associated Non-Coding RNAs.
CU688225 - Synthetic construct Homo sapiens gateway clone IMAGE:100021020 3' read SFRS2 mRNA.
AF015188 - Homo sapiens clone ET42 ET mRNA, alternatively spliced partial sequence.
LF328459 - JP 2014500723-A/135962: Polycomb-Associated Non-Coding RNAs.
AF015189 - Homo sapiens clone ET51 ET mRNA, alternatively spliced partial sequence.
LF328460 - JP 2014500723-A/135963: Polycomb-Associated Non-Coding RNAs.
HZ483494 - JP 2015535430-A/4000: TERMINALLY MODIFIED RNA.
HZ793425 - JP 2016504050-A/5170: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC516157 - Sequence 6410 from Patent WO2014113089.
LQ073745 - Sequence 4069 from Patent EP2964234.
AF015190 - Homo sapiens clone ET61 ET mRNA, alternatively spliced partial sequence.
AF015187 - Homo sapiens clone ET32 ET mRNA, alternatively spliced partial sequence.
AF015186 - Homo sapiens clone ET22 ET putative translation product (ET) mRNA, alternatively spliced complete cds.
AF015183 - Homo sapiens clone ET12 ET mRNA, alternatively spliced partial sequence.
AF015185 - Homo sapiens clone ET10 ET putative translation product (ET) mRNA, alternatively spliced complete cds.
BC002753 - Homo sapiens major facilitator superfamily domain containing 11, mRNA (cDNA clone MGC:3827 IMAGE:3629029), complete cds.
BC062563 - Homo sapiens major facilitator superfamily domain containing 11, mRNA (cDNA clone MGC:74917 IMAGE:5140496), complete cds.
AK308058 - Homo sapiens cDNA, FLJ98006.
AF015184 - Homo sapiens clone ET16 ET putative translation product (ET) mRNA, alternatively spliced complete cds.
AK000233 - Homo sapiens cDNA FLJ20226 fis, clone COLF5064.
JD178137 - Sequence 159161 from Patent EP1572962.
KJ894665 - Synthetic construct Homo sapiens clone ccsbBroadEn_04059 MFSD11 gene, encodes complete protein.
CU678164 - Synthetic construct Homo sapiens gateway clone IMAGE:100019455 5' read MFSD11 mRNA.
DQ896233 - Synthetic construct Homo sapiens clone IMAGE:100010693; FLH191405.01L; RZPDo839C1167D hypothetical protein ET (ET) gene, encodes complete protein.
AK025849 - Homo sapiens cDNA: FLJ22196 fis, clone HRC01180, highly similar to AF015184 Homo sapiens clone ET16 ET putative translation product (ET) mRNA.
JD022794 - Sequence 3818 from Patent EP1572962.
JD033667 - Sequence 14691 from Patent EP1572962.
JD061322 - Sequence 42346 from Patent EP1572962.
JD311005 - Sequence 292029 from Patent EP1572962.
JD358609 - Sequence 339633 from Patent EP1572962.
JD451947 - Sequence 432971 from Patent EP1572962.
JD240876 - Sequence 221900 from Patent EP1572962.
JD467965 - Sequence 448989 from Patent EP1572962.
MA647246 - JP 2017113010-A/5170: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA735130 - JP 2017140048-A/4000: TERMINALLY MODIFIED RNA.
MA564036 - JP 2018138019-A/135962: Polycomb-Associated Non-Coding RNAs.
MA564037 - JP 2018138019-A/135963: Polycomb-Associated Non-Coding RNAs.
MA445005 - JP 2018138019-A/16931: Polycomb-Associated Non-Coding RNAs.
MA804299 - JP 2018183181-A/5170: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.

-  Other Names for This Gene
  Alternate Gene Symbols: ET, MFS11_HUMAN, NM_001242534, NP_077287, O43442, O43934, Q9NXI5
UCSC ID: uc002jta.2
RefSeq Accession: NM_001242534
Protein: O43934 (aka MFS11_HUMAN)
CCDS: CCDS11750.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001242534.1
exon count: 14CDS single in 3' UTR: no RNA size: 2850
ORF size: 1350CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2645.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.