Human Gene MARCH2 (uc002mjv.3) Description and Page Index
Description: Homo sapiens membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase (MARCH2), transcript variant 1, mRNA. RefSeq Summary (NM_016496): MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 126.96.36.199). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]. Transcript (Including UTRs) Position: hg19 chr19:8,478,187-8,503,899 Size: 25,713 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr19:8,486,725-8,503,430 Size: 16,706 Coding Exon Count: 4
ID:MARH2_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase MARCH2; EC=6.3.2.-; AltName: Full=Membrane-associated RING finger protein 2; AltName: Full=Membrane-associated RING-CH protein II; Short=MARCH-II; AltName: Full=RING finger protein 172; FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with STX6 (By similarity). Interacts with MARCH3. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Broadly expressed. DOMAIN: The RING-CH-type zinc finger domain is required for E3 ligase activity. SIMILARITY: Contains 1 RING-CH-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P0N8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.