Human Gene ANGPTL6 (uc002mmy.1) Description and Page Index
  Description: Homo sapiens angiopoietin-like 6 (ANGPTL6), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:10,203,013-10,213,425 Size: 10,413 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr19:10,203,265-10,207,239 Size: 3,975 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:10,203,013-10,213,425)mRNA (may differ from genome)Protein (470 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Angiopoietin-related protein 6; AltName: Full=Angiopoietin-like protein 6; AltName: Full=Angiopoietin-related growth factor; AltName: Full=Angiopoietin-related protein 5; Flags: Precursor;
FUNCTION: May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
SUBCELLULAR LOCATION: Secreted (Probable).
SIMILARITY: Contains 1 fibrinogen C-terminal domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ANGPTL6
CDC HuGE Published Literature: ANGPTL6
Positive Disease Associations: protein quantitative trait loci , Thyrotropin
Related Studies:
  1. protein quantitative trait loci
    Melzer ,et al. 2008, A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs), PLoS genetics 2008 4- 5 : e1000072. [PubMed 18464913]
  2. Thyrotropin
    David Melzer et al. PLoS genetics 2008, A genome-wide association study identifies protein quantitative trait loci (pQTLs)., PLoS genetics. [PubMed 18464913]

-  MalaCards Disease Associations
  MalaCards Gene Search: ANGPTL6
Diseases sorted by gene-association score: gnathomiasis (2), enterobiasis (2), obesity (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.58 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 57.52 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.70192-0.368 Picture PostScript Text
3' UTR -77.48252-0.307 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002181 - Fibrinogen_a/b/g_C
IPR014716 - Fibrinogen_a/b/g_C_1
IPR014715 - Fibrinogen_a/b/g_C_2
IPR020837 - Fibrinogen_CS

Pfam Domains:
PF00147 - Fibrinogen beta and gamma chains, C-terminal globular domain

SCOP Domains:
56496 - Fibrinogen C-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q8NI99
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001525 angiogenesis
GO:0007275 multicellular organism development
GO:0030154 cell differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0030141 secretory granule
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  LF208378 - JP 2014500723-A/15881: Polycomb-Associated Non-Coding RNAs.
LF208379 - JP 2014500723-A/15882: Polycomb-Associated Non-Coding RNAs.
AB054064 - Homo sapiens mRNA for AGF, complete cds.
BC142632 - Homo sapiens angiopoietin-like 6, mRNA (cDNA clone MGC:164829 IMAGE:40147717), complete cds.
AY358276 - Homo sapiens clone DNA23339 NL8 (UNQ152) mRNA, complete cds.
AF230330 - Homo sapiens angiopoietin-related protein 5 (ARP5) mRNA, complete cds.
LF375715 - JP 2014500723-A/183218: Polycomb-Associated Non-Coding RNAs.
JD282667 - Sequence 263691 from Patent EP1572962.
JD547082 - Sequence 528106 from Patent EP1572962.
JD232460 - Sequence 213484 from Patent EP1572962.
JD373022 - Sequence 354046 from Patent EP1572962.
JD153974 - Sequence 134998 from Patent EP1572962.
JD060033 - Sequence 41057 from Patent EP1572962.
JD526026 - Sequence 507050 from Patent EP1572962.
JD070372 - Sequence 51396 from Patent EP1572962.
JD464041 - Sequence 445065 from Patent EP1572962.
MA443955 - JP 2018138019-A/15881: Polycomb-Associated Non-Coding RNAs.
MA443956 - JP 2018138019-A/15882: Polycomb-Associated Non-Coding RNAs.
MA611292 - JP 2018138019-A/183218: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A5PKV7, AGF, ANGL6_HUMAN, ARP5, NM_031917, NP_114123, Q8NI99, Q9BZZ0, UNQ152/PRO178
UCSC ID: uc002mmy.1
RefSeq Accession: NM_031917
Protein: Q8NI99 (aka ANGL6_HUMAN)
CCDS: CCDS12224.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_031917.2
exon count: 6CDS single in 3' UTR: no RNA size: 1857
ORF size: 1413CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1722.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.