Human Gene HNRNPUL1 (uc002oqd.4) Description and Page Index
Description: Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1 (HNRNPUL1), transcript variant 1, mRNA. RefSeq Summary (NM_144732): This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]. Transcript (Including UTRs) Position: hg19 chr19:41,770,327-41,813,811 Size: 43,485 Total Exon Count: 15 Strand: + Coding Region Position: hg19 chr19:41,774,133-41,812,470 Size: 38,338 Coding Exon Count: 14
ID:HNRL1_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein U-like protein 1; AltName: Full=Adenovirus early region 1B-associated protein 5; AltName: Full=E1B-55 kDa-associated protein 5; Short=E1B-AP5; FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. SUBUNIT: Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7. INTERACTION: P04637:TP53; NbExp=11; IntAct=EBI-1018153, EBI-366083; SUBCELLULAR LOCATION: Nucleus. DOMAIN: The RGG-box domain is methylated. PTM: Methylated. MISCELLANEOUS: Its methylation is enhanced in the late phase of adenoviral infection. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 SAP domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): HNRNPUL1 CDC HuGE Published Literature: HNRNPUL1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BUJ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.