Human Gene SDPR (uc002utb.3) Description and Page Index
Description: Homo sapiens serum deprivation response (SDPR), mRNA. RefSeq Summary (NM_004657): This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.138824.1, SRR1660803.99200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304141.5/ ENSP00000305675.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr2:192,699,032-192,712,006 Size: 12,975 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr2:192,700,649-192,711,651 Size: 11,003 Coding Exon Count: 2
ID:SDPR_HUMAN DESCRIPTION: RecName: Full=Serum deprivation-response protein; AltName: Full=Cavin-2; AltName: Full=PS-p68; AltName: Full=Phosphatidylserine-binding protein; FUNCTION: May play a role in targeting PRKCA to caveolae (By similarity). SUBUNIT: Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC. INTERACTION: P08567:PLEK; NbExp=4; IntAct=EBI-742141, EBI-2565501; SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae. TISSUE SPECIFICITY: Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle. INDUCTION: Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry. PTM: Phosphorylated on Ser residues. MISCELLANEOUS: Binds phosphatidylserine (PS) in a calcium- independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine. SIMILARITY: Belongs to the PTRF/SDPR family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95810
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.