Human Gene SDPR (uc002utb.3) Description and Page Index
  Description: Homo sapiens serum deprivation response (SDPR), mRNA.
RefSeq Summary (NM_004657): This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.138824.1, SRR1660803.99200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304141.5/ ENSP00000305675.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr2:192,699,032-192,712,006 Size: 12,975 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr2:192,700,649-192,711,651 Size: 11,003 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:192,699,032-192,712,006)mRNA (may differ from genome)Protein (425 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Serum deprivation-response protein; AltName: Full=Cavin-2; AltName: Full=PS-p68; AltName: Full=Phosphatidylserine-binding protein;
FUNCTION: May play a role in targeting PRKCA to caveolae (By similarity).
SUBUNIT: Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC.
INTERACTION: P08567:PLEK; NbExp=4; IntAct=EBI-742141, EBI-2565501;
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae.
TISSUE SPECIFICITY: Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
INDUCTION: Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.
PTM: Phosphorylated on Ser residues.
MISCELLANEOUS: Binds phosphatidylserine (PS) in a calcium- independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.
SIMILARITY: Belongs to the PTRF/SDPR family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.47 RPKM in Lung
Total median expression: 842.68 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -112.29355-0.316 Picture PostScript Text
3' UTR -340.731617-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026752 - Cavin_fam

Pfam Domains:
PF15237 - PTRF/SDPR family

ModBase Predicted Comparative 3D Structure on O95810
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001786 phosphatidylserine binding
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding

Biological Process:
GO:0097320 plasma membrane tubulation

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0045121 membrane raft

-  Descriptions from all associated GenBank mRNAs
  BC016475 - Homo sapiens serum deprivation response (phosphatidylserine binding protein), mRNA (cDNA clone MGC:8984 IMAGE:3882155), complete cds.
JD281229 - Sequence 262253 from Patent EP1572962.
AK026943 - Homo sapiens cDNA: FLJ23290 fis, clone HEP10128, highly similar to AF085481 Homo sapiens serum deprivation response (SDPR) mRNA.
JD245562 - Sequence 226586 from Patent EP1572962.
JD516447 - Sequence 497471 from Patent EP1572962.
AF085481 - Homo sapiens serum deprivation response (SDPR) mRNA, complete cds.
JD333712 - Sequence 314736 from Patent EP1572962.
JD327794 - Sequence 308818 from Patent EP1572962.
AK290378 - Homo sapiens cDNA FLJ78516 complete cds.
JD063684 - Sequence 44708 from Patent EP1572962.
JD413086 - Sequence 394110 from Patent EP1572962.
JD282430 - Sequence 263454 from Patent EP1572962.
JD455991 - Sequence 437015 from Patent EP1572962.
DQ891440 - Synthetic construct clone IMAGE:100004070; FLH176968.01X; RZPDo839B07124D serum deprivation response (phosphatidylserine binding protein) (SDPR) gene, encodes complete protein.
DQ894617 - Synthetic construct Homo sapiens clone IMAGE:100009077; FLH176965.01L; RZPDo839B07123D serum deprivation response (phosphatidylserine binding protein) (SDPR) gene, encodes complete protein.
AB590258 - Synthetic construct DNA, clone: pFN21AE1422, Homo sapiens SDPR gene for serum deprivation response, without stop codon, in Flexi system.
CU677635 - Synthetic construct Homo sapiens gateway clone IMAGE:100017242 5' read SDPR mRNA.
AK311055 - Homo sapiens cDNA, FLJ18097.
JD434660 - Sequence 415684 from Patent EP1572962.
JD127757 - Sequence 108781 from Patent EP1572962.
JD055000 - Sequence 36024 from Patent EP1572962.
JD319690 - Sequence 300714 from Patent EP1572962.
JD380142 - Sequence 361166 from Patent EP1572962.
JD400507 - Sequence 381531 from Patent EP1572962.
JD255426 - Sequence 236450 from Patent EP1572962.
JD228900 - Sequence 209924 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_004657, NP_004648, O95810, SDPR_HUMAN
UCSC ID: uc002utb.3
RefSeq Accession: NM_004657
Protein: O95810 (aka SDPR_HUMAN)
CCDS: CCDS2313.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_004657.5
exon count: 2CDS single in 3' UTR: no RNA size: 3265
ORF size: 1278CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2618.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.