Human Gene SDPR (uc002utb.3) Description and Page Index
  Description: Homo sapiens serum deprivation response (SDPR), mRNA.
RefSeq Summary (NM_004657): This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.138824.1, SRR1660803.99200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304141.5/ ENSP00000305675.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr2:192,699,032-192,712,006 Size: 12,975 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr2:192,700,649-192,711,651 Size: 11,003 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:192,699,032-192,712,006)mRNA (may differ from genome)Protein (425 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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Wikipedia

-  Comments and Description Text from UniProtKB
  ID: SDPR_HUMAN
DESCRIPTION: RecName: Full=Serum deprivation-response protein; AltName: Full=Cavin-2; AltName: Full=PS-p68; AltName: Full=Phosphatidylserine-binding protein;
FUNCTION: May play a role in targeting PRKCA to caveolae (By similarity).
SUBUNIT: Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC.
INTERACTION: P08567:PLEK; NbExp=4; IntAct=EBI-742141, EBI-2565501;
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae.
TISSUE SPECIFICITY: Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
INDUCTION: Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.
PTM: Phosphorylated on Ser residues.
MISCELLANEOUS: Binds phosphatidylserine (PS) in a calcium- independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.
SIMILARITY: Belongs to the PTRF/SDPR family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.47 RPKM in Lung
Total median expression: 842.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -112.29355-0.316 Picture PostScript Text
3' UTR -340.731617-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026752 - Cavin_fam

Pfam Domains:
PF15237 - PTRF/SDPR family

ModBase Predicted Comparative 3D Structure on O95810
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001786 phosphatidylserine binding
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding

Biological Process:
GO:0097320 plasma membrane tubulation

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  BC016475 - Homo sapiens serum deprivation response (phosphatidylserine binding protein), mRNA (cDNA clone MGC:8984 IMAGE:3882155), complete cds.
JD281229 - Sequence 262253 from Patent EP1572962.
AK026943 - Homo sapiens cDNA: FLJ23290 fis, clone HEP10128, highly similar to AF085481 Homo sapiens serum deprivation response (SDPR) mRNA.
JD245562 - Sequence 226586 from Patent EP1572962.
JD516447 - Sequence 497471 from Patent EP1572962.
AF085481 - Homo sapiens serum deprivation response (SDPR) mRNA, complete cds.
JD333712 - Sequence 314736 from Patent EP1572962.
JD327794 - Sequence 308818 from Patent EP1572962.
AK290378 - Homo sapiens cDNA FLJ78516 complete cds.
JD063684 - Sequence 44708 from Patent EP1572962.
JD413086 - Sequence 394110 from Patent EP1572962.
JD282430 - Sequence 263454 from Patent EP1572962.
JD455991 - Sequence 437015 from Patent EP1572962.
DQ891440 - Synthetic construct clone IMAGE:100004070; FLH176968.01X; RZPDo839B07124D serum deprivation response (phosphatidylserine binding protein) (SDPR) gene, encodes complete protein.
DQ894617 - Synthetic construct Homo sapiens clone IMAGE:100009077; FLH176965.01L; RZPDo839B07123D serum deprivation response (phosphatidylserine binding protein) (SDPR) gene, encodes complete protein.
AB590258 - Synthetic construct DNA, clone: pFN21AE1422, Homo sapiens SDPR gene for serum deprivation response, without stop codon, in Flexi system.
CU677635 - Synthetic construct Homo sapiens gateway clone IMAGE:100017242 5' read SDPR mRNA.
AK311055 - Homo sapiens cDNA, FLJ18097.
JD434660 - Sequence 415684 from Patent EP1572962.
JD127757 - Sequence 108781 from Patent EP1572962.
JD055000 - Sequence 36024 from Patent EP1572962.
JD319690 - Sequence 300714 from Patent EP1572962.
JD380142 - Sequence 361166 from Patent EP1572962.
JD400507 - Sequence 381531 from Patent EP1572962.
JD255426 - Sequence 236450 from Patent EP1572962.
JD228900 - Sequence 209924 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_004657, NP_004648, O95810, SDPR_HUMAN
UCSC ID: uc002utb.3
RefSeq Accession: NM_004657
Protein: O95810 (aka SDPR_HUMAN)
CCDS: CCDS2313.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004657.5
exon count: 2CDS single in 3' UTR: no RNA size: 3265
ORF size: 1278CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2618.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.