Human Gene PLK1S1 (uc002wsb.3) Description and Page Index
  Description: Homo sapiens polo-like kinase 1 substrate 1 (PLK1S1), transcript variant 1, mRNA.
RefSeq Summary (NM_018474): The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]. ##Evidence-Data-START## Transcript exon combination :: AK025476.1, SRR3476690.827099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000619189.5/ ENSP00000479542.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr20:21,106,624-21,227,258 Size: 120,635 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr20:21,106,757-21,227,214 Size: 120,458 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:21,106,624-21,227,258)mRNA (may differ from genome)Protein (673 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Centrosomal protein kizuna; AltName: Full=Polo-like kinase 1 substrate 1;
FUNCTION: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
SUBUNIT: Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule- independent and dependent manner, respectively.
PTM: Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.
MISCELLANEOUS: Kizuna means 'bonds' in Japanese.
SIMILARITY: Belongs to the kizuna family.
SEQUENCE CAUTION: Sequence=AAF67652.1; Type=Frameshift; Positions=283; Sequence=AAH39296.1; Type=Frameshift; Positions=279; Sequence=AAP97689.1; Type=Frameshift; Positions=198; Sequence=BAG59066.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.38 RPKM in Colon - Sigmoid
Total median expression: 393.58 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.90133-0.465 Picture PostScript Text
3' UTR -3.5044-0.080 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026742 - Centrosomal_kizuma

ModBase Predicted Comparative 3D Structure on Q2M2Z5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019901 protein kinase binding

Biological Process:
GO:0007051 spindle organization

Cellular Component:
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0042995 cell projection

-  Descriptions from all associated GenBank mRNAs
  LF383744 - JP 2014500723-A/191247: Polycomb-Associated Non-Coding RNAs.
AF451990 - Homo sapiens chromosome 20 unknown mRNA.
BC039296 - Homo sapiens non-protein coding RNA 153, mRNA (cDNA clone IMAGE:5261585), complete cds.
AK293567 - Homo sapiens cDNA FLJ53974 complete cds.
AK293166 - Homo sapiens cDNA FLJ54666 complete cds.
AK025476 - Homo sapiens cDNA: FLJ21823 fis, clone HEP01318, highly similar to AF220187 Homo sapiens uncharacterized hypothalamus protein HT013 mRNA.
BC105093 - Homo sapiens non-protein coding RNA 153, mRNA (cDNA clone MGC:132753 IMAGE:8144096), complete cds.
BC113370 - Homo sapiens non-protein coding RNA 153, mRNA (cDNA clone MGC:141930 IMAGE:8322422), complete cds.
AK295355 - Homo sapiens cDNA FLJ54960 complete cds.
BC045826 - Homo sapiens non-protein coding RNA 153, mRNA (cDNA clone MGC:51171 IMAGE:5262165), complete cds.
HQ258346 - Synthetic construct Homo sapiens clone IMAGE:100072655 Unknown protein gene, encodes complete protein.
KJ899206 - Synthetic construct Homo sapiens clone ccsbBroadEn_08600 PLK1S1 gene, encodes complete protein.
BC065550 - Homo sapiens non-protein coding RNA 153, mRNA (cDNA clone IMAGE:6044235), partial cds.
BC090879 - Homo sapiens non-protein coding RNA 153, mRNA (cDNA clone IMAGE:30393672), partial cds.
BC013055 - Homo sapiens chromosome 20 open reading frame 19, mRNA (cDNA clone IMAGE:3861196), partial cds.
AK296399 - Homo sapiens cDNA FLJ58743 complete cds.
AL110196 - Homo sapiens mRNA; cDNA DKFZp586H021 (from clone DKFZp586H021).
AF220187 - Homo sapiens uncharacterized hypothalamus protein HT013 mRNA, complete cds.
JD061763 - Sequence 42787 from Patent EP1572962.
JD312442 - Sequence 293466 from Patent EP1572962.
JD385087 - Sequence 366111 from Patent EP1572962.
JD128246 - Sequence 109270 from Patent EP1572962.
JD048214 - Sequence 29238 from Patent EP1572962.
JD260012 - Sequence 241036 from Patent EP1572962.
LF349884 - JP 2014500723-A/157387: Polycomb-Associated Non-Coding RNAs.
JD203269 - Sequence 184293 from Patent EP1572962.
JD433718 - Sequence 414742 from Patent EP1572962.
LF349885 - JP 2014500723-A/157388: Polycomb-Associated Non-Coding RNAs.
AK055105 - Homo sapiens cDNA FLJ30543 fis, clone BRAWH2001406.
MA619321 - JP 2018138019-A/191247: Polycomb-Associated Non-Coding RNAs.
MA585461 - JP 2018138019-A/157387: Polycomb-Associated Non-Coding RNAs.
MA585462 - JP 2018138019-A/157388: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DDE9, B4DK54, C20orf19, HT013, KIZ, KIZ_HUMAN, NCRNA00153, NM_018474, NP_060944, Q2M2Z5, Q4G0M8, Q4G0S5, Q5BKY3, Q6P0M6, Q71ME0, Q9NZ35, uc010zsj.2
UCSC ID: uc002wsb.3
RefSeq Accession: NM_018474
Protein: Q2M2Z5 (aka KIZ_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_018474.4
exon count: 13CDS single in 3' UTR: no RNA size: 2329
ORF size: 2021CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2553.00frame shift in genome: yes % Coverage: 94.29
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.