Human Gene SYS1-DBNDD2 (uc002xnx.3) Description and Page Index
  Description: Homo sapiens SYS1-DBNDD2 readthrough (NMD candidate) (SYS1-DBNDD2), non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr20:43,991,809-44,039,250 Size: 47,442 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr20:44,037,108-44,038,780 Size: 1,673 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:43,991,809-44,039,250)mRNA (may differ from genome)Protein (161 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: DBND2_HUMAN
DESCRIPTION: RecName: Full=Dysbindin domain-containing protein 2; Short=Casein kinase-1 binding protein; AltName: Full=CK1BP; AltName: Full=HSMNP1;
FUNCTION: May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).
SUBUNIT: Monomer. Interacts with CSNK1D and CSNK1E.
TISSUE SPECIFICITY: Detected in brain.
SIMILARITY: Belongs to the dysbindin family.

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.66 RPKM in Fallopian Tube
Total median expression: 6.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -158.22388-0.408 Picture PostScript Text
3' UTR -128.31470-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007531 - Dysbindin

Pfam Domains:
PF04440 - Dysbindin (Dystrobrevin binding protein 1)

ModBase Predicted Comparative 3D Structure on Q9BQY9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006469 negative regulation of protein kinase activity
GO:0031175 neuron projection development

Cellular Component:
GO:0005737 cytoplasm
GO:0030672 synaptic vesicle membrane


-  Descriptions from all associated GenBank mRNAs
  AK075264 - Homo sapiens cDNA FLJ90783 fis, clone THYRO1001327.
AK172738 - Homo sapiens cDNA PSEC0194 fis, clone: HEMBA1001279.
AX775821 - Sequence 91 from Patent WO03048202.
BC048286 - Homo sapiens SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae), mRNA (cDNA clone MGC:51951 IMAGE:5212523), complete cds.
JD471105 - Sequence 452129 from Patent EP1572962.
BC023562 - Homo sapiens dysbindin (dystrobrevin binding protein 1) domain containing 2, mRNA (cDNA clone IMAGE:3639906).
AL591714 - Novel human gene mapping to chomosome 20.
JD142058 - Sequence 123082 from Patent EP1572962.
JD336544 - Sequence 317568 from Patent EP1572962.
JD149925 - Sequence 130949 from Patent EP1572962.
AK309429 - Homo sapiens cDNA, FLJ99470.
JD179833 - Sequence 160857 from Patent EP1572962.
KJ895113 - Synthetic construct Homo sapiens clone ccsbBroadEn_04507 SYS1 gene, encodes complete protein.
EU832322 - Synthetic construct Homo sapiens clone HAIB:100067351; DKFZo008E0627 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) protein (SYS1) gene, encodes complete protein.
EU832407 - Synthetic construct Homo sapiens clone HAIB:100067436; DKFZo004E0628 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) protein (SYS1) gene, encodes complete protein.
AF220191 - Homo sapiens uncharacterized hypothalamus protein HSMNP1 mRNA, complete cds.
LF211868 - JP 2014500723-A/19371: Polycomb-Associated Non-Coding RNAs.
AK026642 - Homo sapiens cDNA: FLJ22989 fis, clone KAT11824, highly similar to AF220191 Homo sapiens uncharacterized hypothalamus protein HSMNP1 mRNA.
AJ276469 - Homo sapiens mRNA for hypothetical protein (ORF1 DNA), clone STRAIT 06042.
BC001105 - Homo sapiens dysbindin (dystrobrevin binding protein 1) domain containing 2, mRNA (cDNA clone MGC:834 IMAGE:2959575), complete cds.
BC012818 - Homo sapiens dysbindin (dystrobrevin binding protein 1) domain containing 2, mRNA (cDNA clone MGC:4222 IMAGE:2959575), complete cds.
AL591565 - Novel human gene mapping to chomosome 20.
AK000531 - Homo sapiens cDNA FLJ20524 fis, clone KAT10570.
AY113697 - Homo sapiens SCF apoptosis response protein-1 mRNA, complete cds.
AB463592 - Synthetic construct DNA, clone: pF1KB8370, Homo sapiens DBNDD2 gene for dysbindin (dystrobrevin binding protein 1) domain containing 2, without stop codon, in Flexi system.
AM393126 - Synthetic construct Homo sapiens clone IMAGE:100002583 for hypothetical protein (DBNDD2 gene).
AM393396 - Synthetic construct Homo sapiens clone IMAGE:100002582 for hypothetical protein (DBNDD2 gene).
AM393681 - Synthetic construct Homo sapiens clone IMAGE:100002568 for hypothetical protein (DBNDD2 gene).
CU674552 - Synthetic construct Homo sapiens gateway clone IMAGE:100017946 5' read DBNDD2 mRNA.
KJ899207 - Synthetic construct Homo sapiens clone ccsbBroadEn_08601 DBNDD2 gene, encodes complete protein.
JD525106 - Sequence 506130 from Patent EP1572962.
JD536012 - Sequence 517036 from Patent EP1572962.
JD172140 - Sequence 153164 from Patent EP1572962.
JD543974 - Sequence 524998 from Patent EP1572962.
JD182311 - Sequence 163335 from Patent EP1572962.
JD510989 - Sequence 492013 from Patent EP1572962.
JD268761 - Sequence 249785 from Patent EP1572962.
JD184929 - Sequence 165953 from Patent EP1572962.
JD094390 - Sequence 75414 from Patent EP1572962.
JD088300 - Sequence 69324 from Patent EP1572962.
JD291417 - Sequence 272441 from Patent EP1572962.
JD456126 - Sequence 437150 from Patent EP1572962.
MA447445 - JP 2018138019-A/19371: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: C20orf35, DBND2_HUMAN, DBNDD2, NM_001197140, NP_001184069, NR_003189, Q5QPV4, Q9BQY9, Q9BQZ0, Q9BVL1, Q9H1F6, Q9NWZ0, Q9NY07, Q9NZ31
UCSC ID: uc002xnx.3
RefSeq Accession: NM_001197140
Protein: Q9BQY9 (aka DBND2_HUMAN)
CCDS: CCDS42880.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_003189.2
exon count: 6CDS single in 3' UTR: no RNA size: 1344
ORF size: 486CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 890.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.