Human Gene PTTG1IP (uc002zgb.2) Description and Page Index
  Description: Homo sapiens pituitary tumor-transforming 1 interacting protein (PTTG1IP), mRNA.
RefSeq Summary (NM_004339): This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013].
Transcript (Including UTRs)
   Position: hg19 chr21:46,269,500-46,293,818 Size: 24,319 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr21:46,271,496-46,293,531 Size: 22,036 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:46,269,500-46,293,818)mRNA (may differ from genome)Protein (180 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PTTG_HUMAN
DESCRIPTION: RecName: Full=Pituitary tumor-transforming gene 1 protein-interacting protein; AltName: Full=Pituitary tumor-transforming gene protein-binding factor; Short=PBF; Short=PTTG-binding factor; Flags: Precursor;
FUNCTION: May facilitate PTTG1 nuclear translocation.
SUBUNIT: Interacts with PTTG1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Nucleus. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.
TISSUE SPECIFICITY: Ubiquitous.
INDUCTION: By transcription factor RUNX2.
SIMILARITY: Contains 1 PSI domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTTG1IPID41944ch21q22.html";

-  MalaCards Disease Associations
  MalaCards Gene Search: PTTG1IP
Diseases sorted by gene-association score: estrogen-receptor positive breast cancer (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 134.23 RPKM in Artery - Aorta
Total median expression: 3515.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.90287-0.491 Picture PostScript Text
3' UTR -700.701996-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003659 - Plexin-like

ModBase Predicted Comparative 3D Structure on P53801
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002039 p53 binding
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0006606 protein import into nucleus
GO:0031398 positive regulation of protein ubiquitination
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903364 positive regulation of cellular protein catabolic process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC020983 - Homo sapiens pituitary tumor-transforming 1 interacting protein, mRNA (cDNA clone MGC:9720 IMAGE:3851447), complete cds.
AF149785 - Homo sapiens pituitary tumor-transforming gene protein binding factor (PBF) mRNA, complete cds.
BC013729 - Homo sapiens pituitary tumor-transforming 1 interacting protein, mRNA (cDNA clone IMAGE:3859592), partial cds.
AK095586 - Homo sapiens cDNA FLJ38267 fis, clone FCBBF3001912.
L48984 - Homo sapiens CTG repeat mRNA.
BC019295 - Homo sapiens pituitary tumor-transforming 1 interacting protein, mRNA (cDNA clone MGC:4109 IMAGE:2823814), complete cds.
BC000415 - Homo sapiens pituitary tumor-transforming 1 interacting protein, mRNA (cDNA clone MGC:8625 IMAGE:2961420), complete cds.
BC034250 - Homo sapiens pituitary tumor-transforming 1 interacting protein, mRNA (cDNA clone MGC:9826 IMAGE:3862830), complete cds.
Z50022 - H.sapiens mRNA for surface glycoprotein.
AK094882 - Homo sapiens cDNA FLJ37563 fis, clone BRCOC2000637, highly similar to SURFACE GLYCOPROTEIN C21ORF1 PRECURSOR.
BC031097 - Homo sapiens pituitary tumor-transforming 1 interacting protein, mRNA (cDNA clone MGC:33930 IMAGE:5288388), complete cds.
BC012858 - Homo sapiens pituitary tumor-transforming 1 interacting protein, mRNA (cDNA clone MGC:9271 IMAGE:3857505), complete cds.
JD224435 - Sequence 205459 from Patent EP1572962.
JD317695 - Sequence 298719 from Patent EP1572962.
JD074721 - Sequence 55745 from Patent EP1572962.
JD043395 - Sequence 24419 from Patent EP1572962.
JD497072 - Sequence 478096 from Patent EP1572962.
JD218659 - Sequence 199683 from Patent EP1572962.
JD347163 - Sequence 328187 from Patent EP1572962.
JD129794 - Sequence 110818 from Patent EP1572962.
JD216301 - Sequence 197325 from Patent EP1572962.
AK298557 - Homo sapiens cDNA FLJ58034 complete cds, moderately similar to Pituitary tumor-transforming gene 1protein-interacting protein precursor.
JD156274 - Sequence 137298 from Patent EP1572962.
JD057447 - Sequence 38471 from Patent EP1572962.
JD339251 - Sequence 320275 from Patent EP1572962.
JD408799 - Sequence 389823 from Patent EP1572962.
JD223765 - Sequence 204789 from Patent EP1572962.
AK293318 - Homo sapiens cDNA FLJ59177 complete cds, weakly similar to Pituitary tumor-transforming gene 1protein-interacting protein precursor.
JD370383 - Sequence 351407 from Patent EP1572962.
JD082469 - Sequence 63493 from Patent EP1572962.
JD359087 - Sequence 340111 from Patent EP1572962.
JD306118 - Sequence 287142 from Patent EP1572962.
AK290139 - Homo sapiens cDNA FLJ78227 complete cds, highly similar to Homo sapiens pituitary tumor-transforming 1 interacting protein (PTTG1IP), mRNA.
JD267110 - Sequence 248134 from Patent EP1572962.
AK299204 - Homo sapiens cDNA FLJ57175 complete cds, moderately similar to Pituitary tumor-transforming gene 1 protein-interacting protein precursor.
JD139628 - Sequence 120652 from Patent EP1572962.
JD282897 - Sequence 263921 from Patent EP1572962.
JD427466 - Sequence 408490 from Patent EP1572962.
JD450890 - Sequence 431914 from Patent EP1572962.
DQ599183 - Homo sapiens piRNA piR-37249, complete sequence.
JD134921 - Sequence 115945 from Patent EP1572962.
JD452312 - Sequence 433336 from Patent EP1572962.
AK315626 - Homo sapiens cDNA, FLJ96710, Homo sapiens pituitary tumor-transforming 1 interacting protein(PTTG1IP), mRNA.
DQ891772 - Synthetic construct clone IMAGE:100004402; FLH179793.01X; RZPDo839C10132D pituitary tumor-transforming 1 interacting protein (PTTG1IP) gene, encodes complete protein.
KJ905700 - Synthetic construct Homo sapiens clone ccsbBroadEn_15370 PTTG1IP gene, encodes complete protein.
DQ894956 - Synthetic construct Homo sapiens clone IMAGE:100009416; FLH179789.01L; RZPDo839C10131D pituitary tumor-transforming 1 interacting protein (PTTG1IP) gene, encodes complete protein.
AB528540 - Synthetic construct DNA, clone: pF1KB0949, Homo sapiens PTTG1IP gene for pituitary tumor-transforming 1 interacting protein, without stop codon, in Flexi system.
JD139936 - Sequence 120960 from Patent EP1572962.
JD217707 - Sequence 198731 from Patent EP1572962.
JD477955 - Sequence 458979 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDP7, C21orf1, C21orf3, D3DSL9, NM_004339, NP_004330, P53801, PTTG_HUMAN, Q9NS09
UCSC ID: uc002zgb.2
RefSeq Accession: NM_004339
Protein: P53801 (aka PTTG_HUMAN)
CCDS: CCDS13715.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004339.3
exon count: 6CDS single in 3' UTR: no RNA size: 2843
ORF size: 543CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 965.00frame shift in genome: no % Coverage: 99.40
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.