Human Gene PTTG1IP (uc002zgb.2) Description and Page Index
Description: Homo sapiens pituitary tumor-transforming 1 interacting protein (PTTG1IP), mRNA. RefSeq Summary (NM_004339): This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]. Transcript (Including UTRs) Position: hg19 chr21:46,269,500-46,293,818 Size: 24,319 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr21:46,271,496-46,293,531 Size: 22,036 Coding Exon Count: 6
ID:PTTG_HUMAN DESCRIPTION: RecName: Full=Pituitary tumor-transforming gene 1 protein-interacting protein; AltName: Full=Pituitary tumor-transforming gene protein-binding factor; Short=PBF; Short=PTTG-binding factor; Flags: Precursor; FUNCTION: May facilitate PTTG1 nuclear translocation. SUBUNIT: Interacts with PTTG1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Nucleus. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus. TISSUE SPECIFICITY: Ubiquitous. INDUCTION: By transcription factor RUNX2. SIMILARITY: Contains 1 PSI domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTTG1IPID41944ch21q22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53801
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006606 protein import into nucleus GO:0031398 positive regulation of protein ubiquitination GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1903364 positive regulation of cellular protein catabolic process