Human Gene CABIN1 (uc002zzl.2) Description and Page Index
Description: Homo sapiens calcineurin binding protein 1 (CABIN1), transcript variant 1, mRNA. RefSeq Summary (NM_001199281): Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr22:24,407,820-24,574,596 Size: 166,777 Total Exon Count: 37 Strand: + Coding Region Position: hg19 chr22:24,431,966-24,574,164 Size: 142,199 Coding Exon Count: 36
ID:CABIN_HUMAN DESCRIPTION: RecName: Full=Calcineurin-binding protein cabin-1; AltName: Full=Calcineurin inhibitor; Short=CAIN; FUNCTION: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. SUBUNIT: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with calcineurin. Interacts with MEF2B. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed in different tissues. PTM: Activated through PKC-mediated hyperphosphorylation. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 6 TPR repeats. SEQUENCE CAUTION: Sequence=BAA20788.2; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CABIN1 CDC HuGE Published Literature: CABIN1 Positive Disease Associations: Heart Failure Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6J0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.