Human Gene MTFP1 (uc003ahv.1) Description and Page Index
  Description: Homo sapiens mitochondrial fission process 1 (MTFP1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.
RefSeq Summary (NM_001204204): This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].
Transcript (Including UTRs)
   Position: hg19 chr22:30,805,176-30,825,041 Size: 19,866 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr22:30,805,424-30,824,521 Size: 19,098 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:30,805,176-30,825,041)mRNA (may differ from genome)Protein (328 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: H7C417_HUMAN
DESCRIPTION: SubName: Full=Uncharacterized protein; Flags: Fragment;
SIMILARITY: Contains 1 CRAL-TRIO domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.40105-0.309 Picture PostScript Text
3' UTR -218.10520-0.419 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001251 - CRAL-TRIO_dom
IPR009038 - GOLD
IPR019560 - Mitochondrial_18_kDa_protein_

Pfam Domains:
PF00650 - CRAL/TRIO domain
PF10558 - Mitochondrial 18 KDa protein (MTP18)

SCOP Domains:
101576 - Supernatant protein factor (SPF), C-terminal domain
52087 - CRAL/TRIO domain

ModBase Predicted Comparative 3D Structure on H7C417
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AL096881 - Novel human mRNA similar to Rattus norvegicus 45 kDa secretory protein, AJ132352.
AK223587 - Homo sapiens mRNA for SEC14-like 2 variant, clone: FCC130E01.
BC048337 - Homo sapiens SEC14-like 2 (S. cerevisiae), mRNA (cDNA clone IMAGE:5212661), partial cds.
AK314390 - Homo sapiens cDNA, FLJ95164, highly similar to Homo sapiens SEC14-like 2 (S. cerevisiae) (SEC14L2), mRNA.
AK091402 - Homo sapiens cDNA FLJ34083 fis, clone FCBBF3004409, highly similar to SEC14-like protein 2.
BC058915 - Homo sapiens SEC14-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:65053 IMAGE:5178251), complete cds.
AB033012 - Homo sapiens KIAA1186 mRNA for KIAA1186 protein.
CR456571 - Homo sapiens SEC14L2 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.SEC14L2).
AK303751 - Homo sapiens cDNA FLJ53690 complete cds, highly similar to SEC14-like protein 2.
AK296540 - Homo sapiens cDNA FLJ54104 complete cds, highly similar to SEC14-like protein 2.
CU013458 - Homo sapiens SEC14L2, mRNA (cDNA clone IMAGE:100000428), complete cds, without stop codon, in Gateway system.
CU013170 - Homo sapiens SEC14L2, mRNA (cDNA clone IMAGE:100000524), complete cds, with stop codon, in Gateway system.
AB384131 - Synthetic construct DNA, clone: pF1KSDA1186, Homo sapiens SEC14L2 gene for SEC14-like protein 2, complete cds, without stop codon, in Flexi system.
AY927438 - Homo sapiens mRNA sequence.
AY927439 - Homo sapiens mRNA sequence.
AK056163 - Homo sapiens cDNA FLJ31601 fis, clone NT2RI2002592.
AY927434 - Homo sapiens mRNA sequence.
AY927435 - Homo sapiens mRNA sequence.
AY927436 - Homo sapiens mRNA sequence.
AY927437 - Homo sapiens mRNA sequence.
AY927441 - Homo sapiens mRNA sequence.
AY927432 - Homo sapiens mRNA sequence.
AY927433 - Homo sapiens mRNA sequence.
AY927440 - Homo sapiens mRNA sequence.
AY927431 - Homo sapiens mRNA sequence.
AY927442 - Homo sapiens mRNA sequence.
LF208978 - JP 2014500723-A/16481: Polycomb-Associated Non-Coding RNAs.
AF151076 - Homo sapiens HSPC242 mRNA, complete cds.
AF060924 - Homo sapiens clone 018d05 My022 protein mRNA, complete cds.
BC030989 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:32665 IMAGE:4077757), complete cds.
AK026104 - Homo sapiens cDNA: FLJ22451 fis, clone HRC09639, highly similar to AF151076 Homo sapiens HSPC242 mRNA.
BC038831 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:47650 IMAGE:3908299), complete cds.
BC009300 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:15180 IMAGE:4126237), complete cds.
BC001608 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:876 IMAGE:3542567), complete cds.
BC014446 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:22998 IMAGE:4855192), complete cds.
CR456345 - Homo sapiens Em:AC004832.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.Em:AC004832.1.V2).
BC046132 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:57612 IMAGE:4446034), complete cds.
KJ898917 - Synthetic construct Homo sapiens clone ccsbBroadEn_08311 MTFP1 gene, encodes complete protein.
KJ893935 - Synthetic construct Homo sapiens clone ccsbBroadEn_03329 MTFP1 gene, encodes complete protein.
AB528187 - Synthetic construct DNA, clone: pF1KE0518, Homo sapiens MTP18 gene for mitochondrial protein 18 kDa, without stop codon, in Flexi system.
CU013344 - Homo sapiens Em:AC004832.C22.1, mRNA (cDNA clone IMAGE:100000218), complete cds, without stop codon, in Gateway system.
CU013056 - Homo sapiens Em:AC004832.C22.1, mRNA (cDNA clone IMAGE:100000314), complete cds, with stop codon, in Gateway system.
LF324607 - JP 2014500723-A/132110: Polycomb-Associated Non-Coding RNAs.
JD085392 - Sequence 66416 from Patent EP1572962.
LF324606 - JP 2014500723-A/132109: Polycomb-Associated Non-Coding RNAs.
JD466392 - Sequence 447416 from Patent EP1572962.
LF324605 - JP 2014500723-A/132108: Polycomb-Associated Non-Coding RNAs.
JD474267 - Sequence 455291 from Patent EP1572962.
JD224392 - Sequence 205416 from Patent EP1572962.
JD193048 - Sequence 174072 from Patent EP1572962.
MA560184 - JP 2018138019-A/132110: Polycomb-Associated Non-Coding RNAs.
MA560183 - JP 2018138019-A/132109: Polycomb-Associated Non-Coding RNAs.
MA560182 - JP 2018138019-A/132108: Polycomb-Associated Non-Coding RNAs.
MA444555 - JP 2018138019-A/16481: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AY927431, H7C417, H7C417_HUMAN, NM_001204204, NP_001191133
UCSC ID: uc003ahv.1
RefSeq Accession: NM_001204204
Protein: H7C417

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AY927431.1
exon count: 9CDS single in 3' UTR: no RNA size: 1470
ORF size: 987CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2030.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.