Human Gene MTFP1 (uc003ahx.2) Description and Page Index
  Description: Homo sapiens mitochondrial fission process 1 (MTFP1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
RefSeq Summary (NM_001003704): MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr22:30,821,611-30,825,041 Size: 3,431 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr22:30,821,868-30,824,661 Size: 2,794 Coding Exon Count: 3 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:30,821,611-30,825,041)mRNA (may differ from genome)Protein (135 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.62 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 51.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -112.00257-0.436 Picture PostScript Text
3' UTR -147.90380-0.389 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF10558 - Mitochondrial 18 KDa protein (MTP18)

ModBase Predicted Comparative 3D Structure on Q9UDX5-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AY927432 - Homo sapiens mRNA sequence.
AY927433 - Homo sapiens mRNA sequence.
AY927440 - Homo sapiens mRNA sequence.
AY927431 - Homo sapiens mRNA sequence.
AY927442 - Homo sapiens mRNA sequence.
LF208978 - JP 2014500723-A/16481: Polycomb-Associated Non-Coding RNAs.
AF151076 - Homo sapiens HSPC242 mRNA, complete cds.
JD375483 - Sequence 356507 from Patent EP1572962.
AF060924 - Homo sapiens clone 018d05 My022 protein mRNA, complete cds.
BC030989 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:32665 IMAGE:4077757), complete cds.
AK026104 - Homo sapiens cDNA: FLJ22451 fis, clone HRC09639, highly similar to AF151076 Homo sapiens HSPC242 mRNA.
BC038831 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:47650 IMAGE:3908299), complete cds.
BC009300 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:15180 IMAGE:4126237), complete cds.
BC001608 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:876 IMAGE:3542567), complete cds.
BC014446 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:22998 IMAGE:4855192), complete cds.
JD087994 - Sequence 69018 from Patent EP1572962.
CR456345 - Homo sapiens Em:AC004832.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.Em:AC004832.1.V2).
BC046132 - Homo sapiens mitochondrial protein 18 kDa, mRNA (cDNA clone MGC:57612 IMAGE:4446034), complete cds.
KJ898917 - Synthetic construct Homo sapiens clone ccsbBroadEn_08311 MTFP1 gene, encodes complete protein.
KJ893935 - Synthetic construct Homo sapiens clone ccsbBroadEn_03329 MTFP1 gene, encodes complete protein.
AB528187 - Synthetic construct DNA, clone: pF1KE0518, Homo sapiens MTP18 gene for mitochondrial protein 18 kDa, without stop codon, in Flexi system.
CU013344 - Homo sapiens Em:AC004832.C22.1, mRNA (cDNA clone IMAGE:100000218), complete cds, without stop codon, in Gateway system.
CU013056 - Homo sapiens Em:AC004832.C22.1, mRNA (cDNA clone IMAGE:100000314), complete cds, with stop codon, in Gateway system.
JD085392 - Sequence 66416 from Patent EP1572962.
LF324606 - JP 2014500723-A/132109: Polycomb-Associated Non-Coding RNAs.
JD466392 - Sequence 447416 from Patent EP1572962.
LF324605 - JP 2014500723-A/132108: Polycomb-Associated Non-Coding RNAs.
JD474267 - Sequence 455291 from Patent EP1572962.
JD224392 - Sequence 205416 from Patent EP1572962.
JD193048 - Sequence 174072 from Patent EP1572962.
MA560183 - JP 2018138019-A/132109: Polycomb-Associated Non-Coding RNAs.
MA560182 - JP 2018138019-A/132108: Polycomb-Associated Non-Coding RNAs.
MA444555 - JP 2018138019-A/16481: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: HSPC242, MTP18, My022, NM_001003704, NP_001003704, Q9UDX5-2
UCSC ID: uc003ahx.2
RefSeq Accession: NM_001003704
Protein: Q9UDX5-2, splice isoform of Q9UDX5 CCDS: CCDS33634.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001003704.2
exon count: 3CDS single in 3' UTR: no RNA size: 1065
ORF size: 408CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 989.00frame shift in genome: no % Coverage: 98.12
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.