Human Gene LIMK2 (uc003akh.3) Description and Page Index
Description: Homo sapiens LIM domain kinase 2 (LIMK2), transcript variant 2a, mRNA. RefSeq Summary (NM_005569): There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr22:31,608,250-31,676,066 Size: 67,817 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr22:31,608,395-31,674,427 Size: 66,033 Coding Exon Count: 16
ID:LIMK2_HUMAN DESCRIPTION: RecName: Full=LIM domain kinase 2; Short=LIMK-2; EC=126.96.36.199; FUNCTION: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Binds ROCK1 and LKAP. Interacts with PARD3. Interacts with NISCH (By similarity). SUBCELLULAR LOCATION: Isoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus. SUBCELLULAR LOCATION: Isoform LIMK2b: Cytoplasm. Nucleus. Note=Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus. TISSUE SPECIFICITY: Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. PTM: Phosphorylated on serine and/or threonine residues by ROCK1. SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SIMILARITY: Contains 2 LIM zinc-binding domains. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAB54055.1; Type=Erroneous gene model prediction;
Genetic Association Studies of Complex Diseases and Disorders
Diabetic Nephropathies Caitrin W McDonough et al. Kidney international 2011, A genome-wide association study for diabetic nephropathy genes in African Americans., Kidney international.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53671
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.