Human Gene LIMK2 (uc003akk.3) Description and Page Index
Description: Homo sapiens LIM domain kinase 2 (LIMK2), transcript variant 2b, mRNA. RefSeq Summary (NM_016733): There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr22:31,644,348-31,676,066 Size: 31,719 Total Exon Count: 15 Strand: + Coding Region Position: hg19 chr22:31,644,703-31,674,427 Size: 29,725 Coding Exon Count: 15
Diabetic Nephropathies Caitrin W McDonough et al. Kidney international 2011, A genome-wide association study for diabetic nephropathy genes in African Americans., Kidney international.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain PF00412 - LIM domain PF00595 - PDZ domain (Also known as DHR or GLGF) PF06293 - Lipopolysaccharide kinase (Kdo/WaaP) family PF07714 - Protein tyrosine kinase
ModBase Predicted Comparative 3D Structure on P53671-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.