Human Gene EIF3L (uc003aug.3) Description and Page Index
  Description: Homo sapiens eukaryotic translation initiation factor 3, subunit L (EIF3L), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:38,245,488-38,284,789 Size: 39,302 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr22:38,247,449-38,284,471 Size: 37,023 Coding Exon Count: 10 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:38,245,488-38,284,789)mRNA (may differ from genome)Protein (456 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedStanford SOURCE
UniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 239.45 RPKM in Ovary
Total median expression: 5281.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -250.34745-0.336 Picture PostScript Text
3' UTR -80.90318-0.254 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019382 - TIF3_suL
IPR011990 - TPR-like_helical

Pfam Domains:
PF10255 - RNA polymerase I-associated factor PAF67
PF12862 - Anaphase-promoting complex subunit 5

ModBase Predicted Comparative 3D Structure on B0QY90
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003743 translation initiation factor activity

Biological Process:
GO:0001732 formation of cytoplasmic translation initiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation

Cellular Component:
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex


-  Descriptions from all associated GenBank mRNAs
  AK056129 - Homo sapiens cDNA FLJ31567 fis, clone NT2RI2001540, highly similar to Eukaryotic translation initiation factor 3 subunit 6-interacting protein.
CR456436 - Homo sapiens dJ1014D13.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ1014D13.1).
AB463035 - Synthetic construct DNA, clone: pF1KB9575, Homo sapiens EIF3EIP gene for eukaryotic translation initiation factor 3, subunit E interacting protein, without stop codon, in Flexi system.
CU013323 - Homo sapiens EIF3S6IP, mRNA (cDNA clone IMAGE:100000197), complete cds, without stop codon, in Gateway system.
CU013035 - Homo sapiens EIF3S6IP, mRNA (cDNA clone IMAGE:100000293), complete cds, with stop codon, in Gateway system.
AK315533 - Homo sapiens cDNA, FLJ96599, Homo sapiens eukaryotic translation initiation factor 3, subunit 6interacting protein (EIF3S6IP), mRNA.
AK222496 - Homo sapiens mRNA for eukaryotic translation initiation factor 3 subunit 6 interacting protein variant, clone: adSE00183.
AF083243 - Homo sapiens HSPC025 mRNA, complete cds.
AK129648 - Homo sapiens cDNA FLJ26137 fis, clone TMS04609.
AK222529 - Homo sapiens mRNA for eukaryotic translation initiation factor 3 subunit 6 interacting protein variant, clone: adSE01547.
AK302346 - Homo sapiens cDNA FLJ52802 complete cds, highly similar to Eukaryotic translation initiation factor 3subunit 6-interacting protein.
AK301323 - Homo sapiens cDNA FLJ53220 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 6-interacting protein.
BC029265 - Homo sapiens eukaryotic translation initiation factor 3, subunit L, mRNA (cDNA clone MGC:34917 IMAGE:5110941), complete cds.
BC001101 - Homo sapiens eukaryotic translation initiation factor 3, subunit L, mRNA (cDNA clone MGC:735 IMAGE:3507964), complete cds.
BC001814 - Homo sapiens eukaryotic translation initiation factor 3, subunit 6 interacting protein, mRNA (cDNA clone IMAGE:2960916), **** WARNING: chimeric clone ****.
BC007510 - Homo sapiens eukaryotic translation initiation factor 3, subunit L, mRNA (cDNA clone MGC:4223 IMAGE:2959747), complete cds.
AF109359 - Homo sapiens MSTP005 mRNA, complete cds.
AK298776 - Homo sapiens cDNA FLJ59381 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 6-interacting protein.
AF077207 - Homo sapiens HSPC021 mRNA, complete cds.
KJ906168 - Synthetic construct Homo sapiens clone ccsbBroadEn_15838 EIF3L gene, encodes complete protein.
KJ893902 - Synthetic construct Homo sapiens clone ccsbBroadEn_03296 EIF3L gene, encodes complete protein.
DQ891842 - Synthetic construct clone IMAGE:100004472; FLH180514.01X; RZPDo839D01134D eukaryotic translation initiation factor 3, subunit 6 interacting protein (EIF3S6IP) gene, encodes complete protein.
DQ893595 - Synthetic construct Homo sapiens clone IMAGE:100006225; FLH263512.01X; RZPDo839C05134D eukaryotic translation initiation factor 3, subunit 6 interacting protein (EIF3S6IP) gene, encodes complete protein.
DQ895030 - Synthetic construct Homo sapiens clone IMAGE:100009490; FLH180510.01L; RZPDo839D01133D eukaryotic translation initiation factor 3, subunit 6 interacting protein (EIF3S6IP) gene, encodes complete protein.
EU176311 - Synthetic construct Homo sapiens clone IMAGE:100006546; FLH263513.01X; RZPDo839B05251D eukaryotic translation initiation factor 3, subunit E interacting protein (EIF3EIP) gene, encodes complete protein.
AK093540 - Homo sapiens cDNA FLJ36221 fis, clone THYMU2000950, highly similar to Eukaryotic translation initiation factor 3 subunit 6-interacting protein.
AX748192 - Sequence 1717 from Patent EP1308459.
AK027429 - Homo sapiens cDNA FLJ14523 fis, clone NT2RM1000905, highly similar to Eukaryotic translation initiation factor 3 subunit 6-interacting protein.
AK098457 - Homo sapiens cDNA FLJ25591 fis, clone JTH12226.
AK098713 - Homo sapiens cDNA FLJ25847 fis, clone TST08852.
AK293629 - Homo sapiens cDNA FLJ53618 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 6-interacting protein.
AL357455 - Homo sapiens EST from clone 531662, 5' end.
CU688616 - Synthetic construct Homo sapiens gateway clone IMAGE:100019880 5' read EIF3EIP mRNA.
CU674548 - Synthetic construct Homo sapiens gateway clone IMAGE:100017704 5' read EIF3EIP mRNA.
JD022920 - Sequence 3944 from Patent EP1572962.
JD021428 - Sequence 2452 from Patent EP1572962.
JD021186 - Sequence 2210 from Patent EP1572962.
JD027830 - Sequence 8854 from Patent EP1572962.
JD024427 - Sequence 5451 from Patent EP1572962.
JD020282 - Sequence 1306 from Patent EP1572962.
JD028810 - Sequence 9834 from Patent EP1572962.
JD027029 - Sequence 8053 from Patent EP1572962.
JD035931 - Sequence 16955 from Patent EP1572962.
JD019016 - Sequence 40 from Patent EP1572962.
BC011448 - Homo sapiens eukaryotic translation initiation factor 3, subunit L, mRNA (cDNA clone IMAGE:3948879), complete cds.
MF281517 - Homo sapiens miAB28_pre miRNA, complete sequence.
MF281479 - Homo sapiens miAB28 miRNA, complete sequence.
JD103675 - Sequence 84699 from Patent EP1572962.
JD323649 - Sequence 304673 from Patent EP1572962.
JD507717 - Sequence 488741 from Patent EP1572962.
JD127521 - Sequence 108545 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AL022311.1-002, AX748192, B0QY90, B0QY90_HUMAN, EIF3EIP, EIF3S6IP, hCG_41840
UCSC ID: uc003aug.3
RefSeq Accession: NM_016091
Protein: B0QY90

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AX748192.1
exon count: 11CDS single in 3' UTR: no RNA size: 2283
ORF size: 1371CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 2504.00frame shift in genome: no % Coverage: 99.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 534# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.