Human Gene PLXNB2 (uc003bkv.4) Description and Page Index
Description: Homo sapiens plexin B2 (PLXNB2), mRNA. RefSeq Summary (NM_012401): Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.70948.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359337.9/ ENSP00000352288.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr22:50,713,408-50,746,001 Size: 32,594 Total Exon Count: 37 Strand: - Coding Region Position: hg19 chr22:50,714,133-50,729,013 Size: 14,881 Coding Exon Count: 35
ID:PLXB2_HUMAN DESCRIPTION: RecName: Full=Plexin-B2; AltName: Full=MM1; Flags: Precursor; FUNCTION: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro) (By similarity). SUBUNIT: Monomer, and heterodimer with PLXNB1. Interacts with SEMA4C, SEMA4D and SEMA4G (By similarity). Binds MET, ARHGEF11 and ARHGEF12. May also interact with MST1R. INTERACTION: P08581:MET; NbExp=2; IntAct=EBI-722004, EBI-1039152; Q04912:MST1R; NbExp=2; IntAct=EBI-722004, EBI-2637518; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the plexin family. SIMILARITY: Contains 3 IPT/TIG domains. SIMILARITY: Contains 1 Sema domain. SEQUENCE CAUTION: Sequence=BAA21571.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15031
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.