Human Gene MYNN (uc003ffv.3) Description and Page Index
  Description: Homo sapiens myoneurin (MYNN), transcript variant 5, non-coding RNA.
RefSeq Summary (NR_033703): This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010].
Transcript (Including UTRs)
   Position: hg19 chr3:169,490,853-169,507,504 Size: 16,652 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr3:169,497,109-169,504,466 Size: 7,358 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:169,490,853-169,507,504)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIneXtProtOMIM
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MYNN_HUMAN
DESCRIPTION: RecName: Full=Myoneurin; AltName: Full=Zinc finger and BTB domain-containing protein 31;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 8 C2H2-type zinc fingers.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MYNN
CDC HuGE Published Literature: MYNN
Positive Disease Associations: Celiac Disease , Colorectal Neoplasms , Multiple Sclerosis
Related Studies:
  1. Celiac Disease
    Patrick C A Dubois et al. Nature genetics 2010, Multiple common variants for celiac disease influencing immune gene expression., Nature genetics. [PubMed 20190752]
  2. Colorectal Neoplasms
    Richard S Houlston et al. Nature genetics 2010, Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33., Nature genetics. [PubMed 20972440]
  3. Multiple Sclerosis
    Stephen Sawcer et al. Nature 2011, Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis., Nature. [PubMed 21833088]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.17 RPKM in Testis
Total median expression: 177.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -389.991132-0.345 Picture PostScript Text
3' UTR -708.163038-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2VPK
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9NPC7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK092022 - Homo sapiens cDNA FLJ34703 fis, clone MESAN2002844, highly similar to Homo sapiens myoneurin (MYNN), mRNA.
BX648128 - Homo sapiens mRNA; cDNA DKFZp686J1140 (from clone DKFZp686J1140).
BC020610 - Homo sapiens myoneurin, mRNA (cDNA clone IMAGE:4721583), partial cds.
AK312527 - Homo sapiens cDNA, FLJ92895, Homo sapiens myoneurin (MYNN), mRNA.
AK304281 - Homo sapiens cDNA FLJ52196 complete cds, highly similar to Homo sapiens myoneurin (MYNN), mRNA.
AK307916 - Homo sapiens cDNA, FLJ97864.
AK021646 - Homo sapiens cDNA FLJ11584 fis, clone HEMBA1003684, weakly similar to ZINC FINGER PROTEIN 151.
AF076249 - Homo sapiens zinc finger protein SBBIZ1 mRNA, complete cds.
AF155508 - Homo sapiens truncated zinc finger protein SBBIZ1 mRNA, complete cds.
AF148848 - Homo sapiens myoneurin mRNA, complete cds.
BC033620 - Homo sapiens myoneurin, mRNA (cDNA clone MGC:40252 IMAGE:5201998), complete cds.
AB079777 - Homo sapiens mRNA for OSZF, complete cds.
AB079778 - Homo sapiens mRNA for OSZF isoform, complete cds.
JD302943 - Sequence 283967 from Patent EP1572962.
AB528460 - Synthetic construct DNA, clone: pF1KB7832, Homo sapiens MYNN gene for myoneurin, without stop codon, in Flexi system.
KJ899213 - Synthetic construct Homo sapiens clone ccsbBroadEn_08607 MYNN gene, encodes complete protein.
DQ891596 - Synthetic construct clone IMAGE:100004226; FLH178468.01X; RZPDo839D07128D myoneurin (MYNN) gene, encodes complete protein.
DQ894790 - Synthetic construct Homo sapiens clone IMAGE:100009250; FLH178464.01L; RZPDo839D07127D myoneurin (MYNN) gene, encodes complete protein.
AY541761 - Homo sapiens clone CBZ3 myoneurin (MYNN) mRNA, partial cds.
AY515692 - Homo sapiens myoneurin transcript variant m4b (MYNN) mRNA, partial cds.
AY515691 - Homo sapiens myoneurin transcript variant BZA1 (MYNN) mRNA, partial cds.
AL133070 - Homo sapiens mRNA; cDNA DKFZp434C0917 (from clone DKFZp434C0917); partial cds.
AY514901 - Homo sapiens myoneurin (MYNN) mRNA, transcript variant m7b, partial cds.
AY541760 - Homo sapiens clone CBZ2A myoneurin (MYNN) mRNA, partial cds.
JD250390 - Sequence 231414 from Patent EP1572962.
JD236283 - Sequence 217307 from Patent EP1572962.
JD561946 - Sequence 542970 from Patent EP1572962.
JD114504 - Sequence 95528 from Patent EP1572962.
JD370319 - Sequence 351343 from Patent EP1572962.
JD294839 - Sequence 275863 from Patent EP1572962.
JD447596 - Sequence 428620 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R6C9, MYNN_HUMAN, NR_033703, OSZF, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NPC7, Q9NS01, Q9UIW8, SBBIZ1, ZBTB31
UCSC ID: uc003ffv.3
RefSeq Accession: NR_033703
Protein: Q9NPC7 (aka MYNN_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_033703.1
exon count: 8CDS single in 3' UTR: no RNA size: 5184
ORF size: 1014CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1537.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.