Human Gene EIF4G1 (uc003fnx.3) Description and Page Index
  Description: Homo sapiens eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1), transcript variant 5, mRNA.
RefSeq Summary (NM_004953): The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].
Transcript (Including UTRs)
   Position: hg19 chr3:184,038,101-184,053,146 Size: 15,046 Total Exon Count: 26 Strand: +
Coding Region
   Position: hg19 chr3:184,038,469-184,052,696 Size: 14,228 Coding Exon Count: 26 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:184,038,101-184,053,146)mRNA (may differ from genome)Protein (1404 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: EIF4G1
Diseases sorted by gene-association score: parkinson disease 18* (904), eif4g1-related parkinson disease* (100), hereditary late-onset parkinson disease* (10), mouth disease (7)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 108.85 RPKM in Muscle - Skeletal
Total median expression: 2558.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -151.00368-0.410 Picture PostScript Text
3' UTR -216.70450-0.482 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR003891 - Initiation_fac_eIF4g_MI
IPR016021 - MIF4-like_typ_1/2/3
IPR003890 - MIF4G-like_typ-3
IPR003307 - W2_domain

Pfam Domains:
PF02020 - eIF4-gamma/eIF5/eIF2-epsilon
PF02847 - MA3 domain
PF02854 - MIF4G domain

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on G5E9S1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserNo orthologGenome Browser
Gene Details  Gene Details Gene Details
Gene Sorter  Gene Sorter Gene Sorter
   FlyBase SGD
   Protein Sequence Protein Sequence
   Alignment Alignment

-  Descriptions from all associated GenBank mRNAs
  BC065256 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 1, mRNA (cDNA clone IMAGE:6146899), partial cds.
AK299763 - Homo sapiens cDNA FLJ56483 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 1.
AK096719 - Homo sapiens cDNA FLJ39400 fis, clone PLACE6011102, highly similar to EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA.
AK128378 - Homo sapiens cDNA FLJ46521 fis, clone THYMU3033759, moderately similar to Eukaryotic translation initiation factor 4 gamma.
BX647812 - Homo sapiens mRNA; cDNA DKFZp686A1451 (from clone DKFZp686A1451).
AL832754 - Homo sapiens mRNA; cDNA DKFZp686A2427 (from clone DKFZp686A2427).
AK226160 - Homo sapiens mRNA for eukaryotic translation initiation factor 4 gamma, 1 isoform 1 variant, clone: sh03325.
BC010688 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 1, mRNA (cDNA clone IMAGE:3867218), with apparent retained intron.
BC140892 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 1, mRNA (cDNA clone MGC:176569 IMAGE:9021760), complete cds.
BC140896 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 1, mRNA (cDNA clone MGC:176573 IMAGE:9021764), complete cds.
AK131407 - Homo sapiens cDNA FLJ16513 fis, clone MESAN2001770, highly similar to EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA.
AY082886 - Homo sapiens eukaryotic translation initiation factor 4GI (EIF4GI) mRNA, complete cds.
AF281070 - Homo sapiens putative regulatory uORF and eukaryotic translation initiation factor 4G I (EIF4GI) mRNAs, complete cds.
AF002815 - Human eucaryotic translation initiation factor 4G isoform 1 mRNA, partial cds.
AB210013 - Homo sapiens mRNA for EIF4G1 variant protein, clone: fh17714.
AB384368 - Synthetic construct DNA, clone: pF1KSDB0030, Homo sapiens EIF4G1 gene for eukaryotic translation initiation factor 4 gamma 1, complete cds, without stop codon, in Flexi system.
AF002816 - Human eucaryotic translation initiation factor 4G isoform 2 mRNA, partial cds.
AF104913 - Homo sapiens eukaryotic protein synthesis initiation factor mRNA, complete cds.
AK294567 - Homo sapiens cDNA FLJ56479 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 1.
AK308319 - Homo sapiens cDNA, FLJ98267.
D12686 - Homo sapiens mRNA for eukaryotic initiation factor 4 gamma, complete cds.
JD227272 - Sequence 208296 from Patent EP1572962.
JD122111 - Sequence 103135 from Patent EP1572962.
JD060256 - Sequence 41280 from Patent EP1572962.
JD242113 - Sequence 223137 from Patent EP1572962.
JD343435 - Sequence 324459 from Patent EP1572962.
JD208473 - Sequence 189497 from Patent EP1572962.
JD259795 - Sequence 240819 from Patent EP1572962.
JD138092 - Sequence 119116 from Patent EP1572962.
JD104047 - Sequence 85071 from Patent EP1572962.
JD290943 - Sequence 271967 from Patent EP1572962.
JD175757 - Sequence 156781 from Patent EP1572962.
BC082764 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 1, mRNA (cDNA clone IMAGE:6580118).
AJ001046 - Homo sapiens mRNA for eukaryotic initiation factor 4 gamma.
BC007788 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 1, mRNA (cDNA clone IMAGE:3611484), partial cds.
BT007282 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 1 mRNA, complete cds.
AK098133 - Homo sapiens cDNA FLJ40814 fis, clone TRACH2010587, highly similar to EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA.
DL491731 - Novel nucleic acids.
DL490311 - Novel nucleic acids.
JD355037 - Sequence 336061 from Patent EP1572962.
JD454150 - Sequence 435174 from Patent EP1572962.
JD502902 - Sequence 483926 from Patent EP1572962.
JD347052 - Sequence 328076 from Patent EP1572962.
JD537199 - Sequence 518223 from Patent EP1572962.
JD389435 - Sequence 370459 from Patent EP1572962.
JD132726 - Sequence 113750 from Patent EP1572962.
JD483497 - Sequence 464521 from Patent EP1572962.
JD335961 - Sequence 316985 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05416 - Viral myocarditis

BioCarta from NCI Cancer Genome Anatomy Project
h_mTORPathway - mTOR Signaling Pathway
h_iresPathway - Internal Ribosome entry pathway
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_eifPathway - Eukaryotic protein translation

-  Other Names for This Gene
  Alternate Gene Symbols: G5E9S1, G5E9S1_HUMAN, hCG_201245, NM_004953, NP_004944
UCSC ID: uc003fnx.3
RefSeq Accession: NM_004953
Protein: G5E9S1 CCDS: CCDS46970.2, CCDS3261.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004953.4
exon count: 26CDS single in 3' UTR: no RNA size: 5050
ORF size: 4215CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7913.00frame shift in genome: no % Coverage: 99.66
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 317# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.